FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288747416> ?p ?o ?g. }

• W4288747416 endingPage "108806" @default.
• W4288747416 startingPage "108806" @default.
• W4288747416 abstract "Lung cancer is a leading cause of tumor-associated death worldwide. Autophagy plays a key role in regulating lung cancer progression, and is a promising option for lung cancer treatment. Saponins are a group of naturally occurring plant glycosides, characterized by their strong foam-forming properties in aqueous solution, and exert various biological properties, such as anti-inflammation and anti-cancer. In the present study, we for the first time explored the effects of gitogenin (GIT), an important saponin derived from Tribulus longipetalus, on lung cancer progression both in vitro and in vivo. We found that GIT markedly reduced the proliferation and induced apoptosis in lung cancer cells through increasing the cleavage of Caspase-3 and poly (ADP-ribose) polymerases (PARPs). In addition, GIT-incubated lung cancer cells exhibited clear accumulation of autophagosome, which was essential for GIT-suppressed lung cancer. Mechanistically, GIT-induced autophagy initiation was mainly through activating AMP-activated protein kinase (AMPK) and blocking protein kinase B (AKT) signaling pathways, respectively. Moreover, the autophagic flux was disrupted in GIT-treated lung cancer cells, contributing to the accumulation of impaired autophagolysosomes. Importantly, we found that suppressing autophagy initiation could abolish GIT-induced cell death; however, autophagosomes accumulation sensitized lung cancer cells to cell death upon GIT treatment. More in vitro experiments showed that GIT led to reactive oxygen species (ROS) production in lung cancer cells, which was also involved in the modulation of apoptosis. The in vivo findings confirmed the effects of GIT against lung cancer progression with undetectable toxicity to organs. In conclusion, we provided new insights into the treatment of lung cancer, and GIT might be an effective strategy for future clinical application." @default.
• W4288747416 created "2022-07-30" @default.
• W4288747416 creator A5022062761 @default.
• W4288747416 creator A5041353443 @default.
• W4288747416 creator A5063089557 @default.
• W4288747416 creator A5064842058 @default.
• W4288747416 creator A5079985604 @default.
• W4288747416 date "2022-10-01" @default.
• W4288747416 modified "2023-09-30" @default.
• W4288747416 title "Gitogenin suppresses lung cancer progression by inducing apoptosis and autophagy initiation through the activation of AMPK signaling" @default.
• W4288747416 cites W1534985842 @default.
• W4288747416 cites W1922145593 @default.
• W4288747416 cites W1965912776 @default.
• W4288747416 cites W1970165340 @default.
• W4288747416 cites W1970637701 @default.
• W4288747416 cites W1999954853 @default.
• W4288747416 cites W2007906101 @default.
• W4288747416 cites W2012422873 @default.
• W4288747416 cites W2027236817 @default.
• W4288747416 cites W2032794217 @default.
• W4288747416 cites W2035692638 @default.
• W4288747416 cites W2040599763 @default.
• W4288747416 cites W2043151422 @default.
• W4288747416 cites W2045122835 @default.
• W4288747416 cites W2046838202 @default.
• W4288747416 cites W2055811314 @default.
• W4288747416 cites W2075998349 @default.
• W4288747416 cites W2076653569 @default.
• W4288747416 cites W2102748761 @default.
• W4288747416 cites W2104830962 @default.
• W4288747416 cites W2110084716 @default.
• W4288747416 cites W2114787032 @default.
• W4288747416 cites W2116249563 @default.
• W4288747416 cites W2117505049 @default.
• W4288747416 cites W2148298497 @default.
• W4288747416 cites W2148550663 @default.
• W4288747416 cites W2150026213 @default.
• W4288747416 cites W2167430243 @default.
• W4288747416 cites W2190286596 @default.
• W4288747416 cites W2243864136 @default.
• W4288747416 cites W2273029502 @default.
• W4288747416 cites W2275270276 @default.
• W4288747416 cites W2288529957 @default.
• W4288747416 cites W2344685573 @default.
• W4288747416 cites W2415692875 @default.
• W4288747416 cites W2423216298 @default.
• W4288747416 cites W2468576628 @default.
• W4288747416 cites W2471277546 @default.
• W4288747416 cites W2475248934 @default.
• W4288747416 cites W2489373060 @default.
• W4288747416 cites W2507922791 @default.
• W4288747416 cites W2508069933 @default.
• W4288747416 cites W2514386754 @default.
• W4288747416 cites W2526873982 @default.
• W4288747416 cites W2528981876 @default.
• W4288747416 cites W2531335099 @default.
• W4288747416 cites W2535300095 @default.
• W4288747416 cites W2555280699 @default.
• W4288747416 cites W2558713280 @default.
• W4288747416 cites W2565923023 @default.
• W4288747416 cites W2581120722 @default.
• W4288747416 cites W2592029987 @default.
• W4288747416 cites W2608470234 @default.
• W4288747416 cites W2611224317 @default.
• W4288747416 cites W2625887862 @default.
• W4288747416 cites W2740618823 @default.
• W4288747416 cites W2763195445 @default.
• W4288747416 cites W2771702326 @default.
• W4288747416 cites W2775794300 @default.
• W4288747416 cites W2778979323 @default.
• W4288747416 cites W2793773126 @default.
• W4288747416 cites W2799473901 @default.
• W4288747416 cites W2799763930 @default.
• W4288747416 cites W2800427169 @default.
• W4288747416 cites W2889188357 @default.
• W4288747416 cites W2889498668 @default.
• W4288747416 cites W2889827548 @default.
• W4288747416 cites W2900518472 @default.
• W4288747416 cites W2949011674 @default.
• W4288747416 cites W2980582475 @default.
• W4288747416 cites W2996498230 @default.
• W4288747416 cites W3005209905 @default.
• W4288747416 cites W3012638502 @default.
• W4288747416 cites W3013190319 @default.
• W4288747416 cites W3014653431 @default.
• W4288747416 cites W3017060188 @default.
• W4288747416 cites W3032396467 @default.
• W4288747416 cites W3033001818 @default.
• W4288747416 cites W3043032183 @default.
• W4288747416 cites W3043122898 @default.
• W4288747416 cites W3078914032 @default.
• W4288747416 cites W3110378028 @default.
• W4288747416 cites W3163483547 @default.
• W4288747416 cites W3184443678 @default.
• W4288747416 cites W3194987234 @default.
• W4288747416 cites W4294214970 @default.
• W4288747416 doi "https://doi.org/10.1016/j.intimp.2022.108806" @default.
• W4288747416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35914447" @default.

• next