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- W4288748441 abstract "Programmable gene editing systems such as CRISPR-Cas have made mosquito genome engineering more practical and accessible, catalyzing the development of cutting-edge genetic methods of disease vector control. This progress, however, has been limited by the low efficiency of homology-directed repair (HDR)-based sequence integration at DNA double-strand breaks (DSBs) and a lack of understanding about DSB repair in mosquitoes. Innovative efforts to optimize HDR sequence integration by inhibiting non-homologous end joining or promoting HDR have been performed in mammalian systems, however many of these approaches have not been applied to mosquitoes. Here, we review some of the most relevant steps of DNA DSB repair choice and highlight promising approaches that influence this choice to enhance HDR in the context of mosquito gene editing." @default.
- W4288748441 created "2022-07-30" @default.
- W4288748441 creator A5003033184 @default.
- W4288748441 creator A5041538677 @default.
- W4288748441 creator A5088503493 @default.
- W4288748441 date "2022-07-30" @default.
- W4288748441 modified "2023-10-14" @default.
- W4288748441 title "Strategies to improve homology-based repair outcomes following CRISPR-based gene editing in mosquitoes: lessons in how to keep any repair disruptions local" @default.
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- W4288748441 doi "https://doi.org/10.1186/s12985-022-01859-2" @default.
- W4288748441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35908059" @default.
- W4288748441 hasPublicationYear "2022" @default.
- W4288748441 type Work @default.
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