FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288748445> ?p ?o ?g. }

• W4288748445 abstract "Abstract Carbapenem-resistant Gram-negative bacteria are frequent causes of sepsis and septic shock in intensive care unit (ICU) and thus considered a public health threat. Until now, the best available therapies consist of combinations of preexisting or new antibiotics with β-lactamase inhibitors (either new or preexisting). Several mechanisms of resistance, especially those mediated by metallo-β-lactamases (MBL), are responsible for the inefficacy of these treatments, leaving an unmet medical need. Intravenous cefiderocol has been recently approved by the American Food and Drug Administration (FDA) and European Medicines Agency (EMA) for the treatment of complicated urinary tract infections and nosocomial pneumonia due to Gram-negative, when limited therapeutical options are available. In addition, its ability to hijack bacterial iron uptake mechanisms makes cefiderocol stable against the whole Ambler β-lactamase inhibitors and increases the in vitro efficacy against Gram-negative pathogens (e.g., Enterobacterales spp., Pseudomonas aeruginosa , and Acinetobacter baumannii ). Trials have already demonstrated their non-inferiority to comparators. In 2021, ESCMID guidelines released a conditional recommendation supporting the use of cefiderocol against metallo-β-lactamase-producing Enterobacterales and against Acinetobacter baumannii . This review provides the opinion of experts about the general management of empiric treatment of patients with sepsis and septic shock in the intensive care unit and detects the proper place in therapy of cefiderocol considering recent evidence sought through a systematic search." @default.
• W4288748445 created "2022-07-30" @default.
• W4288748445 creator A5004595193 @default.
• W4288748445 creator A5037042809 @default.
• W4288748445 creator A5037070847 @default.
• W4288748445 creator A5045135007 @default.
• W4288748445 creator A5067066083 @default.
• W4288748445 creator A5070342971 @default.
• W4288748445 creator A5071676972 @default.
• W4288748445 creator A5071687756 @default.
• W4288748445 creator A5073280348 @default.
• W4288748445 creator A5080501616 @default.
• W4288748445 date "2022-07-30" @default.
• W4288748445 modified "2023-10-14" @default.
• W4288748445 title "Empiric treatment of patients with sepsis and septic shock and place in therapy of cefiderocol: a systematic review and expert opinion statement" @default.
• W4288748445 cites W2050939778 @default.
• W4288748445 cites W2488450895 @default.
• W4288748445 cites W2554894514 @default.
• W4288748445 cites W2594607607 @default.
• W4288748445 cites W2683726696 @default.
• W4288748445 cites W2782246563 @default.
• W4288748445 cites W2897987794 @default.
• W4288748445 cites W2898144230 @default.
• W4288748445 cites W2898221671 @default.
• W4288748445 cites W2900641309 @default.
• W4288748445 cites W2900807296 @default.
• W4288748445 cites W2914558018 @default.
• W4288748445 cites W2965715014 @default.
• W4288748445 cites W2987552683 @default.
• W4288748445 cites W3003144544 @default.
• W4288748445 cites W3003721827 @default.
• W4288748445 cites W3087097003 @default.
• W4288748445 cites W3092173712 @default.
• W4288748445 cites W3092383626 @default.
• W4288748445 cites W3108642752 @default.
• W4288748445 cites W3118495174 @default.
• W4288748445 cites W3118615836 @default.
• W4288748445 cites W3126991086 @default.
• W4288748445 cites W3127842317 @default.
• W4288748445 cites W3129785338 @default.
• W4288748445 cites W3160845742 @default.
• W4288748445 cites W3165004308 @default.
• W4288748445 cites W3195627102 @default.
• W4288748445 cites W3196872974 @default.
• W4288748445 cites W3214904390 @default.
• W4288748445 cites W3217749790 @default.
• W4288748445 cites W4200250437 @default.
• W4288748445 cites W4205838247 @default.
• W4288748445 cites W4210612285 @default.
• W4288748445 cites W4210713828 @default.
• W4288748445 cites W4211020493 @default.
• W4288748445 cites W4213078613 @default.
• W4288748445 cites W4220764592 @default.
• W4288748445 doi "https://doi.org/10.1186/s44158-022-00062-7" @default.
• W4288748445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37386663" @default.
• W4288748445 hasPublicationYear "2022" @default.
• W4288748445 type Work @default.
• W4288748445 citedByCount "1" @default.
• W4288748445 countsByYear W42887484452023 @default.
• W4288748445 crossrefType "journal-article" @default.
• W4288748445 hasAuthorship W4288748445A5004595193 @default.
• W4288748445 hasAuthorship W4288748445A5037042809 @default.
• W4288748445 hasAuthorship W4288748445A5037070847 @default.
• W4288748445 hasAuthorship W4288748445A5045135007 @default.
• W4288748445 hasAuthorship W4288748445A5067066083 @default.
• W4288748445 hasAuthorship W4288748445A5070342971 @default.
• W4288748445 hasAuthorship W4288748445A5071676972 @default.
• W4288748445 hasAuthorship W4288748445A5071687756 @default.
• W4288748445 hasAuthorship W4288748445A5073280348 @default.
• W4288748445 hasAuthorship W4288748445A5080501616 @default.
• W4288748445 hasBestOaLocation W42887484451 @default.
• W4288748445 hasConcept C126322002 @default.
• W4288748445 hasConcept C141071460 @default.
• W4288748445 hasConcept C177713679 @default.
• W4288748445 hasConcept C2776315533 @default.
• W4288748445 hasConcept C2776376669 @default.
• W4288748445 hasConcept C2777628635 @default.
• W4288748445 hasConcept C2777637488 @default.
• W4288748445 hasConcept C2777914695 @default.
• W4288748445 hasConcept C2778384902 @default.
• W4288748445 hasConcept C2779181126 @default.
• W4288748445 hasConcept C501593827 @default.
• W4288748445 hasConcept C523546767 @default.
• W4288748445 hasConcept C54355233 @default.
• W4288748445 hasConcept C71924100 @default.
• W4288748445 hasConcept C86803240 @default.
• W4288748445 hasConcept C89423630 @default.
• W4288748445 hasConceptScore W4288748445C126322002 @default.
• W4288748445 hasConceptScore W4288748445C141071460 @default.
• W4288748445 hasConceptScore W4288748445C177713679 @default.
• W4288748445 hasConceptScore W4288748445C2776315533 @default.
• W4288748445 hasConceptScore W4288748445C2776376669 @default.
• W4288748445 hasConceptScore W4288748445C2777628635 @default.
• W4288748445 hasConceptScore W4288748445C2777637488 @default.
• W4288748445 hasConceptScore W4288748445C2777914695 @default.
• W4288748445 hasConceptScore W4288748445C2778384902 @default.
• W4288748445 hasConceptScore W4288748445C2779181126 @default.
• W4288748445 hasConceptScore W4288748445C501593827 @default.
• W4288748445 hasConceptScore W4288748445C523546767 @default.
• W4288748445 hasConceptScore W4288748445C54355233 @default.

• next