Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288752181> ?p ?o ?g. }
- W4288752181 endingPage "674" @default.
- W4288752181 startingPage "665" @default.
- W4288752181 abstract "Abstract Production and secretion of IgE by B cells, plasmablasts, and plasma cells is a central step in the development and maintenance of allergic diseases. IgE can bind to one of its receptors, the low-affinity IgE receptor CD23, which is expressed on activated B cells. As a result, most B cells bind IgE through CD23 on their surface. This makes the identification of IgE producing cells challenging. In this study, we report an approach to clearly identify live IgE+ plasmablasts in peripheral blood for application by both flow cytometry analysis and in vitro assay. These IgE+ plasmablasts readily secrete IgE, upregulate specific mRNA transcripts (BLIMP-1 IRF4, XBP1, CD138, and TACI), and exhibit highly differentiated morphology all consistent with plasmablast differentiation. Most notably, we compared the presence of IgE+ plasmablasts in peripheral blood of allergic and healthy individuals using a horse model of naturally occurring seasonal allergy, Culicoides hypersensitivity. The model allows the comparison of immune cells both during periods of clinical allergy and when in remission and clinically healthy. Allergic horses had significantly higher percentages of IgE+ plasmablasts and IgE secretion while experiencing clinical allergy compared with healthy horses. Allergy severity and IgE secretion were both positively correlated to the frequency of IgE+ plasmablasts in peripheral blood. These results provide strong evidence for the identification and quantification of peripheral IgE-secreting plasmablasts and provide a missing cellular link in the mechanism of IgE secretion and upregulation during allergy." @default.
- W4288752181 created "2022-07-30" @default.
- W4288752181 creator A5057290159 @default.
- W4288752181 creator A5068890681 @default.
- W4288752181 creator A5080002885 @default.
- W4288752181 date "2022-08-15" @default.
- W4288752181 modified "2023-10-18" @default.
- W4288752181 title "Peripheral CD23hi/IgE+ Plasmablasts Secrete IgE and Correlate with Allergic Disease Severity" @default.
- W4288752181 cites W1494211513 @default.
- W4288752181 cites W1792467427 @default.
- W4288752181 cites W1855016645 @default.
- W4288752181 cites W1859806174 @default.
- W4288752181 cites W1906224138 @default.
- W4288752181 cites W1966047769 @default.
- W4288752181 cites W1970759336 @default.
- W4288752181 cites W1981024696 @default.
- W4288752181 cites W1987753923 @default.
- W4288752181 cites W1992663146 @default.
- W4288752181 cites W2004145744 @default.
- W4288752181 cites W2007147688 @default.
- W4288752181 cites W2009076031 @default.
- W4288752181 cites W2013097888 @default.
- W4288752181 cites W2016952830 @default.
- W4288752181 cites W2034963119 @default.
- W4288752181 cites W2040454220 @default.
- W4288752181 cites W2040640809 @default.
- W4288752181 cites W2044831278 @default.
- W4288752181 cites W2046517086 @default.
- W4288752181 cites W2052360985 @default.
- W4288752181 cites W2053932966 @default.
- W4288752181 cites W2056892026 @default.
- W4288752181 cites W2058688703 @default.
- W4288752181 cites W2061993413 @default.
- W4288752181 cites W2064681544 @default.
- W4288752181 cites W2064696967 @default.
- W4288752181 cites W2070334379 @default.
- W4288752181 cites W2070341074 @default.
- W4288752181 cites W2075650829 @default.
- W4288752181 cites W2077900612 @default.
- W4288752181 cites W2085764531 @default.
- W4288752181 cites W2087058561 @default.
- W4288752181 cites W2100628873 @default.
- W4288752181 cites W2106874385 @default.
- W4288752181 cites W2120588519 @default.
- W4288752181 cites W2126595174 @default.
- W4288752181 cites W2147687447 @default.
- W4288752181 cites W2165405363 @default.
- W4288752181 cites W2170063984 @default.
- W4288752181 cites W2170136419 @default.
- W4288752181 cites W2346668818 @default.
- W4288752181 cites W2396289223 @default.
- W4288752181 cites W2404659073 @default.
- W4288752181 cites W2407255712 @default.
- W4288752181 cites W2592692910 @default.
- W4288752181 cites W2743779163 @default.
- W4288752181 cites W2766148171 @default.
- W4288752181 cites W2779357254 @default.
- W4288752181 cites W2789376456 @default.
- W4288752181 cites W2792945854 @default.
- W4288752181 cites W2883462033 @default.
- W4288752181 cites W2903856687 @default.
- W4288752181 cites W2906102362 @default.
- W4288752181 cites W2930143113 @default.
- W4288752181 cites W2969582750 @default.
- W4288752181 cites W2969630323 @default.
- W4288752181 cites W2970651795 @default.
- W4288752181 cites W2980639756 @default.
- W4288752181 cites W2997794562 @default.
- W4288752181 cites W3010721985 @default.
- W4288752181 cites W3012761948 @default.
- W4288752181 cites W3028300075 @default.
- W4288752181 cites W3039215635 @default.
- W4288752181 cites W3048863920 @default.
- W4288752181 cites W3096455780 @default.
- W4288752181 cites W3117764278 @default.
- W4288752181 cites W3121721551 @default.
- W4288752181 cites W3159234635 @default.
- W4288752181 cites W3162908845 @default.
- W4288752181 cites W4313310180 @default.
- W4288752181 doi "https://doi.org/10.4049/jimmunol.2101081" @default.
- W4288752181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35896336" @default.
- W4288752181 hasPublicationYear "2022" @default.
- W4288752181 type Work @default.
- W4288752181 citedByCount "2" @default.
- W4288752181 countsByYear W42887521812023 @default.
- W4288752181 crossrefType "journal-article" @default.
- W4288752181 hasAuthorship W4288752181A5057290159 @default.
- W4288752181 hasAuthorship W4288752181A5068890681 @default.
- W4288752181 hasAuthorship W4288752181A5080002885 @default.
- W4288752181 hasBestOaLocation W42887521811 @default.
- W4288752181 hasConcept C126322002 @default.
- W4288752181 hasConcept C137061746 @default.
- W4288752181 hasConcept C141105273 @default.
- W4288752181 hasConcept C159654299 @default.
- W4288752181 hasConcept C202751555 @default.
- W4288752181 hasConcept C203014093 @default.
- W4288752181 hasConcept C207480886 @default.
- W4288752181 hasConcept C34814297 @default.