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- W4288753266 abstract "Although CD4 and CD8 T-cells are the main subset of T-lymphocytes, their roles in COVID-19 infection and severity remain unclear. This study aimed to determine the role of increased CD4/CD8 T-cells ratio as a risk factor for cases of 28-days in-hospital mortality in COVID-19 patients.This study employed a prospective cohort design. Inclusion criteria were confirmed COVID-19 cases with a positive polymerase chain reaction report. CD4 and CD8 T-cells absolute counts were measured by flow cytometry. The CD4/CD8 ratio was calculated by dividing the absolute count of CD4 by that of CD8 T-cells.A total of 85 subjects were followed for 28 days. The mean age of the subjects was 52.64 years, and majority of them were females (51.8%). Twenty-eight (32.9%) subjects died within 28 days of follow-up. Receiver operating characteristics analysis obtained an area under curve of 0.68 with the cut-off value 1.26 with p = 0.005. Kaplan-Meier's analysis obtained Hazard Ratio 2.91 (95%CI 1.377-6.161; p = 0.0052).Subjects with an increase in CD4/CD8 T-cells ratio >1.26 had a 2.91-times risk of 28 days in-hospital mortality." @default.
- W4288753266 created "2022-07-30" @default.
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- W4288753266 date "2022-07-01" @default.
- W4288753266 modified "2023-10-03" @default.
- W4288753266 title "Increased CD4/CD8 T-cell ratio : A risk factor for mortality in patients with coronavirus disease 2019." @default.
- W4288753266 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35899885" @default.
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