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- W4288771823 abstract "Regulation of cell death and survival programs is critical for maintenance of cellular homeostasis and therefore perturbations in pathways can contribute to development of many diseases. Inhibitor of apoptosis (IAP) proteins are regulators of cell death which exert anti-apoptotic activity by interfering with apoptotic signaling through death receptors or intrinsic cell death pathways. A common feature of all IAP proteins is the presence of the baculovirus-IAP-repeat (BIR) domain(s), which enables them to bind caspases and/or engage other signaling proteins. Another important structural feature of several IAP proteins is the presence of the really interesting new gene (RING) domain, which confers E3 activity for ubiquitination of target proteins for degradation or promotion of signaling. Moreover, due to elevated expression levels of IAPs in many different types of cancers and IAP mutations associated with inflammatory diseases, significant efforts have been made towards development of therapeutics targeting IAP proteins. In this article, we will discuss the structure and function of IAP proteins, their roles in cancer and inflammatory diseases, and recent advances in targeting IAPs for therapeutic intervention." @default.
- W4288771823 created "2022-07-30" @default.
- W4288771823 creator A5025125940 @default.
- W4288771823 creator A5048067233 @default.
- W4288771823 date "2023-01-01" @default.
- W4288771823 modified "2023-09-25" @default.
- W4288771823 title "Inhibitors of Apoptosis are Critical Signaling Mediators in Inflammation and Cancer" @default.
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