Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288773732> ?p ?o ?g. }
- W4288773732 endingPage "53" @default.
- W4288773732 startingPage "33" @default.
- W4288773732 abstract "Coordinated communication between and within cells forms the basis for life in health and disease of all tissues and organs. Such relaying of information is mediated by neurotransmitters, hormones, bacteria, viruses, steroids, and a host of cyto- and chemokines via specific receptors, ion channels, and transporters located in cellular membranes and intracellular organelles including the nuclear membrane and within the nucleus itself. Activation of such transmembrane components generates intracellular second messengers such as cyclic adenosine monophosphate, cyclic guanine monophosphate, inositol phosphates, diacylglycerol, Ca2+, and gaseous transmitters such as nitric oxide and hydrogen sulfide that modulate the activity of cytoplasmic proteins, lipids, and other substances via phosphorylation, dephosphorylation, glycation, and acetylation. Additional communication is achieved by modulation of genetic machinery, via transcription factors, various chaperones, and through secretome/exosome-mediated release of growth factors, microRNAs, and via direct transfer of many of the afore-mentioned chemicals between neighboring cells down nanotunnels. Dysfunctions within any component of this signal transduction machinery, whether in excess or deficiency or by mutation, result in some form of diseases and thus represent targets for intervention by small molecule drugs, peptides, antibodies, genetic manipulation, and/or via cell-replacement therapeutics. A brief outline of some of these elements will be discussed." @default.
- W4288773732 created "2022-07-30" @default.
- W4288773732 creator A5024909155 @default.
- W4288773732 date "2022-01-01" @default.
- W4288773732 modified "2023-09-25" @default.
- W4288773732 title "Receptors, ion channels, and signal transduction pathways as targets for drug intervention to mitigate ocular diseases" @default.
- W4288773732 cites W1120357221 @default.
- W4288773732 cites W1485297825 @default.
- W4288773732 cites W1965197534 @default.
- W4288773732 cites W1965448424 @default.
- W4288773732 cites W1965988585 @default.
- W4288773732 cites W1968682237 @default.
- W4288773732 cites W1973109321 @default.
- W4288773732 cites W1973274094 @default.
- W4288773732 cites W1974732432 @default.
- W4288773732 cites W1980315610 @default.
- W4288773732 cites W1981528056 @default.
- W4288773732 cites W1985689227 @default.
- W4288773732 cites W1987502158 @default.
- W4288773732 cites W2001465234 @default.
- W4288773732 cites W2003576140 @default.
- W4288773732 cites W2007287124 @default.
- W4288773732 cites W2008660560 @default.
- W4288773732 cites W2009120970 @default.
- W4288773732 cites W2010179280 @default.
- W4288773732 cites W2010608134 @default.
- W4288773732 cites W2017591799 @default.
- W4288773732 cites W2017975008 @default.
- W4288773732 cites W2019132331 @default.
- W4288773732 cites W2021307653 @default.
- W4288773732 cites W2022805799 @default.
- W4288773732 cites W2024894359 @default.
- W4288773732 cites W2025077803 @default.
- W4288773732 cites W2037682190 @default.
- W4288773732 cites W2049329844 @default.
- W4288773732 cites W2050662511 @default.
- W4288773732 cites W2053234631 @default.
- W4288773732 cites W2056499152 @default.
- W4288773732 cites W2057983478 @default.
- W4288773732 cites W2059593140 @default.
- W4288773732 cites W2059925177 @default.
- W4288773732 cites W2065154461 @default.
- W4288773732 cites W2065486056 @default.
- W4288773732 cites W2065774664 @default.
- W4288773732 cites W2065926532 @default.
- W4288773732 cites W2070314270 @default.
- W4288773732 cites W2071605868 @default.
- W4288773732 cites W2075320389 @default.
- W4288773732 cites W2092433290 @default.
- W4288773732 cites W2111525045 @default.
- W4288773732 cites W2160145914 @default.
- W4288773732 cites W2164020272 @default.
- W4288773732 cites W2247769468 @default.
- W4288773732 cites W2328231397 @default.
- W4288773732 cites W2337435709 @default.
- W4288773732 cites W2415876289 @default.
- W4288773732 cites W2483776236 @default.
- W4288773732 cites W2528491208 @default.
- W4288773732 cites W2587153788 @default.
- W4288773732 cites W2611012155 @default.
- W4288773732 cites W2731862025 @default.
- W4288773732 cites W2742777852 @default.
- W4288773732 cites W2745688041 @default.
- W4288773732 cites W2747725012 @default.
- W4288773732 cites W2764021582 @default.
- W4288773732 cites W2769904229 @default.
- W4288773732 cites W2772147343 @default.
- W4288773732 cites W2773591092 @default.
- W4288773732 cites W2783753655 @default.
- W4288773732 cites W2783861782 @default.
- W4288773732 cites W2794190081 @default.
- W4288773732 cites W2799627453 @default.
- W4288773732 cites W2803214839 @default.
- W4288773732 cites W2805148808 @default.
- W4288773732 cites W2884672778 @default.
- W4288773732 cites W2884793927 @default.
- W4288773732 cites W2887429619 @default.
- W4288773732 cites W2901824420 @default.
- W4288773732 cites W2907519411 @default.
- W4288773732 cites W2923660809 @default.
- W4288773732 cites W2944782385 @default.
- W4288773732 cites W2954247683 @default.
- W4288773732 cites W2982327720 @default.
- W4288773732 cites W2984021260 @default.
- W4288773732 cites W2995463243 @default.
- W4288773732 cites W2996346739 @default.
- W4288773732 cites W3003165719 @default.
- W4288773732 cites W3013561740 @default.
- W4288773732 cites W3014690129 @default.
- W4288773732 cites W3016064490 @default.
- W4288773732 cites W3017005220 @default.
- W4288773732 cites W3028537558 @default.
- W4288773732 cites W3032360571 @default.
- W4288773732 cites W3035005545 @default.
- W4288773732 cites W3040960321 @default.
- W4288773732 cites W3080261933 @default.
- W4288773732 cites W3096374942 @default.
- W4288773732 doi "https://doi.org/10.1016/b978-0-12-819291-7.00017-4" @default.