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- W4288789596 abstract "There is a long-standing relationship between trillions of microbes and human beings. Microbes and humans have coevolved, involving synergistic, commensal, and pathogenic interaction with microbes. The sustenance of a huge diversity of microbes that are harbored in the human body poses a significant question to the success of the self–nonself discrimination by our immune system and elimination of any potential antigens. The evolutionary coexistence of microbes in the human body and the development of a robust immune system prompt the evolutionary benefit of this tolerized response of the immune system toward specific microbes. There is an emerging understanding of the role of microbes in shaping our immune system that is crucial for tumor progression and autoimmunity. With advances in microbial research through sequencing, metabolomics, proteomics, and bioinformatics approaches, the deeper and more intricate role of microbes has been brought to focus. The vast gut microbiota is now thought to play a very sophisticated and intricately balanced role in determining prognosis of various health conditions. The microbiota is not only responsible for metabolic processes but also a role in progression and regression of complex ailments such as cancer. Cancer is caused by genetic aberrations and certain hallmarks are used to define cancer and its stages. There is a very complex interplay in place between the three components, microbiota, cancer, and host immune system. Microbiota being a part of tumor microenvironment can modulate the immunological responses, drug efficacies and play a crucial role in immunotherapies." @default.
- W4288789596 created "2022-07-30" @default.
- W4288789596 creator A5012399883 @default.
- W4288789596 creator A5033902472 @default.
- W4288789596 date "2022-01-01" @default.
- W4288789596 modified "2023-10-16" @default.
- W4288789596 title "Introduction" @default.
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