FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288808418> ?p ?o ?g. }

• W4288808418 endingPage "106378" @default.
• W4288808418 startingPage "106378" @default.
• W4288808418 abstract "Aberrant activation of the Hh pathway promotes cell proliferation and multi-drug resistance (MDR) in several cancers, including Acute Myeloid Leukemia (AML). Notably, only one Hh inhibitor, glasdegib, has been approved for AML treatment, and most patients eventually relapse, highlighting the urgent need to discover new therapeutic targets. Hh signal is transduced through the membrane of the primary cilium, a structure expressed by non-proliferating mammalian cells, whose stabilization depends on the activity of HDAC6. Here we describe a positive correlation between Hh, HDAC6, and MDR genes in a cohort of adult AML patients, human leukemic cell lines, and a zebrafish model of Hh overexpression. The hyper-activation of Hh or HDAC6 in zebrafish drove the increased proliferation of hematopoietic stem and progenitor cells (HSPCs). Interestingly, this phenotype was rescued by inhibition of HDAC6 but not of Hh. Also, in human leukemic cell lines, a reduction in vitality was obtained through HDAC6, but not Hh inhibition. Our data showed the presence of a cross-talk between Hh and HDAC6 mediated by stabilization of the primary cilium, which we detect for the first time in zebrafish HSPCs. Inhibition of HDAC6 activity alone or in combination therapy with the chemotherapeutic agent cytarabine, efficiently rescued the hematopoietic phenotype. Our results open the possibility to introduce HDAC6 as therapeutic target to reduce proliferation of leukemic blasts in AML patients." @default.
• W4288808418 created "2022-07-30" @default.
• W4288808418 creator A5014223509 @default.
• W4288808418 creator A5030957556 @default.
• W4288808418 creator A5037319827 @default.
• W4288808418 creator A5039769794 @default.
• W4288808418 creator A5056136982 @default.
• W4288808418 creator A5056583671 @default.
• W4288808418 creator A5063702702 @default.
• W4288808418 creator A5074408803 @default.
• W4288808418 creator A5077252889 @default.
• W4288808418 creator A5080246257 @default.
• W4288808418 creator A5080380601 @default.
• W4288808418 creator A5081843523 @default.
• W4288808418 creator A5087719320 @default.
• W4288808418 date "2022-09-01" @default.
• W4288808418 modified "2023-10-18" @default.
• W4288808418 title "HDAC6 inhibition decreases leukemic stem cell expansion driven by Hedgehog hyperactivation by restoring primary ciliogenesis" @default.
• W4288808418 cites W1527009475 @default.
• W4288808418 cites W1982111644 @default.
• W4288808418 cites W1982986056 @default.
• W4288808418 cites W1992280242 @default.
• W4288808418 cites W1993920645 @default.
• W4288808418 cites W1998849260 @default.
• W4288808418 cites W2020471395 @default.
• W4288808418 cites W2040509977 @default.
• W4288808418 cites W2088342479 @default.
• W4288808418 cites W2088901097 @default.
• W4288808418 cites W2090786177 @default.
• W4288808418 cites W2097416336 @default.
• W4288808418 cites W2110737176 @default.
• W4288808418 cites W2114819889 @default.
• W4288808418 cites W2127422682 @default.
• W4288808418 cites W2148351140 @default.
• W4288808418 cites W2156363416 @default.
• W4288808418 cites W2165275830 @default.
• W4288808418 cites W2171874387 @default.
• W4288808418 cites W2282437010 @default.
• W4288808418 cites W2405593818 @default.
• W4288808418 cites W2419140434 @default.
• W4288808418 cites W2511418953 @default.
• W4288808418 cites W2582028225 @default.
• W4288808418 cites W2777635693 @default.
• W4288808418 cites W2887055543 @default.
• W4288808418 cites W2892157567 @default.
• W4288808418 cites W2896099071 @default.
• W4288808418 cites W2909700677 @default.
• W4288808418 cites W2938245193 @default.
• W4288808418 cites W2940640801 @default.
• W4288808418 cites W2944512335 @default.
• W4288808418 cites W2945843914 @default.
• W4288808418 cites W2994869882 @default.
• W4288808418 cites W2997751023 @default.
• W4288808418 cites W3049655364 @default.
• W4288808418 cites W807610602 @default.
• W4288808418 doi "https://doi.org/10.1016/j.phrs.2022.106378" @default.
• W4288808418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35918044" @default.
• W4288808418 hasPublicationYear "2022" @default.
• W4288808418 type Work @default.
• W4288808418 citedByCount "2" @default.
• W4288808418 countsByYear W42888084182023 @default.
• W4288808418 crossrefType "journal-article" @default.
• W4288808418 hasAuthorship W4288808418A5014223509 @default.
• W4288808418 hasAuthorship W4288808418A5030957556 @default.
• W4288808418 hasAuthorship W4288808418A5037319827 @default.
• W4288808418 hasAuthorship W4288808418A5039769794 @default.
• W4288808418 hasAuthorship W4288808418A5056136982 @default.
• W4288808418 hasAuthorship W4288808418A5056583671 @default.
• W4288808418 hasAuthorship W4288808418A5063702702 @default.
• W4288808418 hasAuthorship W4288808418A5074408803 @default.
• W4288808418 hasAuthorship W4288808418A5077252889 @default.
• W4288808418 hasAuthorship W4288808418A5080246257 @default.
• W4288808418 hasAuthorship W4288808418A5080380601 @default.
• W4288808418 hasAuthorship W4288808418A5081843523 @default.
• W4288808418 hasAuthorship W4288808418A5087719320 @default.
• W4288808418 hasBestOaLocation W42888084181 @default.
• W4288808418 hasConcept C100094513 @default.
• W4288808418 hasConcept C104317684 @default.
• W4288808418 hasConcept C109159458 @default.
• W4288808418 hasConcept C195267511 @default.
• W4288808418 hasConcept C201750760 @default.
• W4288808418 hasConcept C23681527 @default.
• W4288808418 hasConcept C2776878037 @default.
• W4288808418 hasConcept C2777605378 @default.
• W4288808418 hasConcept C2778305200 @default.
• W4288808418 hasConcept C2778539099 @default.
• W4288808418 hasConcept C28328180 @default.
• W4288808418 hasConcept C502942594 @default.
• W4288808418 hasConcept C55493867 @default.
• W4288808418 hasConcept C62478195 @default.
• W4288808418 hasConcept C64927066 @default.
• W4288808418 hasConcept C86803240 @default.
• W4288808418 hasConcept C95444343 @default.
• W4288808418 hasConceptScore W4288808418C100094513 @default.
• W4288808418 hasConceptScore W4288808418C104317684 @default.
• W4288808418 hasConceptScore W4288808418C109159458 @default.
• W4288808418 hasConceptScore W4288808418C195267511 @default.
• W4288808418 hasConceptScore W4288808418C201750760 @default.

• next