FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288810588> ?p ?o ?g. }

• W4288810588 endingPage "115196" @default.
• W4288810588 startingPage "115196" @default.
• W4288810588 abstract "An adverse environment during pregnancy leads to intrauterine programming changes in multiple generations, resulting in the multigenerational inheritance of abnormal phenotype. Here, we reported the multigenerational inheritance of poor articular cartilage quality induced by prenatal dexamethasone exposure (PDE) with 0.2 mg/kg·d dexamethasone from gestational day (GD) 9 to GD20 in Wistar rats and investigated its intrauterine epigenetic programming mechanism. For the F1 female offspring at GD20, we found that the matrix synthesis of cartilage was suppressed, the histone 3 lysine 9 acetylation (H3K9ac) level and mRNA expression of the TGFβ signaling pathway were decreased, and the expression of histone deacetylase (HDAC) 2 was increased in the cartilage. Meaningfully, the similar changes were also found in the F1-F3 female adult offspring. Furthermore, PDE decreased the expression of miR-92a-3p in the oocytes of the F1-F2 offspring and in the cartilage of the F1-F3 generations. In vitro, the effect of dexamethasone on chondrocytes revealed that it inhibited the expression of miR-92a-3p through activating and binding glucocorticoid receptor, and reduced the H3K9ac level in the promoter of the TGFβ signaling pathway through the increased HDAC2. In conclusion, PDE induces the multigenerational inheritance of poor articular cartilage quality in female adult offspring; the potential mechanism involves the intergenerational effect of low miR-92a-3p expression in oocytes and low functional programming of TGFβ signaling pathway induced by decreased H3K9ac level via upregulating HDAC2. This study provides a new perspective to explain the multi-generation inheritance of PDE-induced organ dysplasia in adult offspring." @default.
• W4288810588 created "2022-07-30" @default.
• W4288810588 creator A5004471359 @default.
• W4288810588 creator A5008147776 @default.
• W4288810588 creator A5022614068 @default.
• W4288810588 creator A5072904721 @default.
• W4288810588 creator A5075081781 @default.
• W4288810588 creator A5080795237 @default.
• W4288810588 creator A5088448076 @default.
• W4288810588 creator A5088890356 @default.
• W4288810588 date "2022-09-01" @default.
• W4288810588 modified "2023-10-14" @default.
• W4288810588 title "Low miR-92a-3p in oocytes mediates the multigenerational and transgenerational inheritance of poor cartilage quality in rat induced by prenatal dexamethasone exposure" @default.
• W4288810588 cites W1487412251 @default.
• W4288810588 cites W1527648461 @default.
• W4288810588 cites W1603728190 @default.
• W4288810588 cites W1964375939 @default.
• W4288810588 cites W1967064280 @default.
• W4288810588 cites W1970760045 @default.
• W4288810588 cites W1971708895 @default.
• W4288810588 cites W1977082276 @default.
• W4288810588 cites W1979112369 @default.
• W4288810588 cites W1986667734 @default.
• W4288810588 cites W1990370417 @default.
• W4288810588 cites W1993488574 @default.
• W4288810588 cites W2009721053 @default.
• W4288810588 cites W2014668126 @default.
• W4288810588 cites W2021349238 @default.
• W4288810588 cites W2032456711 @default.
• W4288810588 cites W2054194924 @default.
• W4288810588 cites W2055095239 @default.
• W4288810588 cites W2067158285 @default.
• W4288810588 cites W2071213636 @default.
• W4288810588 cites W2076627334 @default.
• W4288810588 cites W2078311949 @default.
• W4288810588 cites W2081039748 @default.
• W4288810588 cites W2090723511 @default.
• W4288810588 cites W2092027270 @default.
• W4288810588 cites W2092250698 @default.
• W4288810588 cites W2097945707 @default.
• W4288810588 cites W2100932663 @default.
• W4288810588 cites W2101524853 @default.
• W4288810588 cites W2103890520 @default.
• W4288810588 cites W2119285041 @default.
• W4288810588 cites W2121836743 @default.
• W4288810588 cites W2123870375 @default.
• W4288810588 cites W2134682046 @default.
• W4288810588 cites W2142718844 @default.
• W4288810588 cites W2159539338 @default.
• W4288810588 cites W2254581328 @default.
• W4288810588 cites W2292034152 @default.
• W4288810588 cites W2480575991 @default.
• W4288810588 cites W2551137278 @default.
• W4288810588 cites W2578920087 @default.
• W4288810588 cites W2744632285 @default.
• W4288810588 cites W2789846955 @default.
• W4288810588 cites W2803207635 @default.
• W4288810588 cites W2805390371 @default.
• W4288810588 cites W2990593734 @default.
• W4288810588 cites W3039278889 @default.
• W4288810588 cites W4254913758 @default.
• W4288810588 cites W77534247 @default.
• W4288810588 cites W871827426 @default.
• W4288810588 doi "https://doi.org/10.1016/j.bcp.2022.115196" @default.
• W4288810588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35917869" @default.
• W4288810588 hasPublicationYear "2022" @default.
• W4288810588 type Work @default.
• W4288810588 citedByCount "1" @default.
• W4288810588 countsByYear W42888105882022 @default.
• W4288810588 crossrefType "journal-article" @default.
• W4288810588 hasAuthorship W4288810588A5004471359 @default.
• W4288810588 hasAuthorship W4288810588A5008147776 @default.
• W4288810588 hasAuthorship W4288810588A5022614068 @default.
• W4288810588 hasAuthorship W4288810588A5072904721 @default.
• W4288810588 hasAuthorship W4288810588A5075081781 @default.
• W4288810588 hasAuthorship W4288810588A5080795237 @default.
• W4288810588 hasAuthorship W4288810588A5088448076 @default.
• W4288810588 hasAuthorship W4288810588A5088890356 @default.
• W4288810588 hasConcept C104317684 @default.
• W4288810588 hasConcept C105702510 @default.
• W4288810588 hasConcept C112672928 @default.
• W4288810588 hasConcept C126322002 @default.
• W4288810588 hasConcept C134018914 @default.
• W4288810588 hasConcept C2778305200 @default.
• W4288810588 hasConcept C2779234561 @default.
• W4288810588 hasConcept C2780401358 @default.
• W4288810588 hasConcept C2780550940 @default.
• W4288810588 hasConcept C41091548 @default.
• W4288810588 hasConcept C54355233 @default.
• W4288810588 hasConcept C64927066 @default.
• W4288810588 hasConcept C71723506 @default.
• W4288810588 hasConcept C71924100 @default.
• W4288810588 hasConcept C86803240 @default.
• W4288810588 hasConceptScore W4288810588C104317684 @default.
• W4288810588 hasConceptScore W4288810588C105702510 @default.
• W4288810588 hasConceptScore W4288810588C112672928 @default.
• W4288810588 hasConceptScore W4288810588C126322002 @default.
• W4288810588 hasConceptScore W4288810588C134018914 @default.

• next