Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289012803> ?p ?o ?g. }
- W4289012803 abstract "Abstract Background Even though fatigue is one of the most prevalent and burdensome symptoms in patients with glioma, its etiology and determinants are still poorly understood. We aimed to identify which demographic, tumor- and treatment-related characteristics and patient-reported outcome measures (PROMs) are associated with or are predictors of fatigue in glioma. Methods In this retrospective observational study, we included glioma patients with preoperative and postoperative assessments including PROMs on fatigue, depression, cognitive functioning, and health-related quality of life (HRQoL). Linear mixed models were used to identify which clinical factors and PROMs were associated with fatigue and linear multiple regression was used to detect predictors of postoperative fatigue. Results In this study, 222 patients were included (78% grade II-III glioma, 22% grade IV). These patients had performed 333 assessments (193 preoperative and 116 one year postoperatively). Of all assessments, 39% was indicative of severe fatigue. Several HRQoL domains, depression, and right-sided tumors were significantly associated with fatigue (marginal R 2 = 0.63). Contrary to common expectations, tumor type, treatment-related factors and timing of the assessment, were not associated with fatigue. In a subgroup of seventy patients with follow-up assessments, preoperative fatigue and physical functioning were predictors of postoperative fatigue (adjusted R 2 = 0.31). Conclusion Fatigue is a complex symptom, which should not solely be attributed to the tumor or its treatment, but is instead related to different aspects of mood and HRQoL. These insights are of importance in understanding fatigue and could guide symptom management, especially in patients with lower grade tumors. Key points Up to 40% of patients are severely fatigued, regardless of tumor type or timing of assessment HRQoL, depression, and right-sided tumor explain 63% of variance in fatigue severity Demographics, tumor type and treatment are not associated with fatigue severity Importance of the Study Despite fatigue being one of the most frequent and burdensome symptoms in patients with glioma, its etiology remains poorly understood. We aimed to unravel the impact of demographic, tumor- and treatment-related factors, symptoms, and HRQoL to grasp the complexity of fatigue in 222 glioma patients. Our findings demonstrate that fatigue is associated with several domains of HRQoL and depression, as well as having a tumor in the right hemisphere. What stands out is that fatigue is not associated with tumor type, treatment-related characteristics or phase of the disease. These findings could be important in symptom management since tumor- and treatment-related factors are non-modifiable, whilst depressive symptoms and social and physical functioning could be more suitable treatment targets. These results underscore the need for timely screening and symptom management focusing not only on fatigue but also on mood and diminished HRQoL." @default.
- W4289012803 created "2022-07-31" @default.
- W4289012803 creator A5013574301 @default.
- W4289012803 creator A5026586641 @default.
- W4289012803 creator A5033673419 @default.
- W4289012803 creator A5074915986 @default.
- W4289012803 creator A5082319404 @default.
- W4289012803 creator A5090414948 @default.
- W4289012803 date "2022-07-31" @default.
- W4289012803 modified "2023-09-27" @default.
- W4289012803 title "Toward unraveling the correlates of fatigue in glioma" @default.
- W4289012803 cites W1514613017 @default.
- W4289012803 cites W1907220812 @default.
- W4289012803 cites W1972357185 @default.
- W4289012803 cites W1986884477 @default.
- W4289012803 cites W2011810065 @default.
- W4289012803 cites W2059051635 @default.
- W4289012803 cites W2059792748 @default.
- W4289012803 cites W2072044537 @default.
- W4289012803 cites W2089666504 @default.
- W4289012803 cites W2091917093 @default.
- W4289012803 cites W2102471539 @default.
- W4289012803 cites W2106825272 @default.
- W4289012803 cites W2112778345 @default.
- W4289012803 cites W2116240299 @default.
- W4289012803 cites W2122624435 @default.
- W4289012803 cites W2123178053 @default.
- W4289012803 cites W2124615973 @default.
- W4289012803 cites W2127329211 @default.
- W4289012803 cites W2142146891 @default.
- W4289012803 cites W2144544687 @default.
- W4289012803 cites W2148601670 @default.
- W4289012803 cites W2160382843 @default.
- W4289012803 cites W2326878192 @default.
- W4289012803 cites W2327037637 @default.
- W4289012803 cites W2612027047 @default.
- W4289012803 cites W2620159843 @default.
- W4289012803 cites W2804962444 @default.
- W4289012803 cites W2888688605 @default.
- W4289012803 cites W2899363944 @default.
- W4289012803 cites W2914606616 @default.
- W4289012803 cites W2944536919 @default.
- W4289012803 cites W2991529774 @default.
- W4289012803 cites W3128064466 @default.
- W4289012803 cites W3132011183 @default.
- W4289012803 cites W3136181285 @default.
- W4289012803 cites W3139363161 @default.
- W4289012803 cites W3189405403 @default.
- W4289012803 cites W3208752017 @default.
- W4289012803 cites W3209393337 @default.
- W4289012803 cites W4225263174 @default.
- W4289012803 cites W4234224939 @default.
- W4289012803 cites W4281490471 @default.
- W4289012803 cites W4285492007 @default.
- W4289012803 doi "https://doi.org/10.1101/2022.07.29.22277995" @default.
- W4289012803 hasPublicationYear "2022" @default.
- W4289012803 type Work @default.
- W4289012803 citedByCount "1" @default.
- W4289012803 countsByYear W42890128032023 @default.
- W4289012803 crossrefType "posted-content" @default.
- W4289012803 hasAuthorship W4289012803A5013574301 @default.
- W4289012803 hasAuthorship W4289012803A5026586641 @default.
- W4289012803 hasAuthorship W4289012803A5033673419 @default.
- W4289012803 hasAuthorship W4289012803A5074915986 @default.
- W4289012803 hasAuthorship W4289012803A5082319404 @default.
- W4289012803 hasAuthorship W4289012803A5090414948 @default.
- W4289012803 hasBestOaLocation W42890128031 @default.
- W4289012803 hasConcept C118552586 @default.
- W4289012803 hasConcept C126322002 @default.
- W4289012803 hasConcept C137627325 @default.
- W4289012803 hasConcept C139719470 @default.
- W4289012803 hasConcept C159110408 @default.
- W4289012803 hasConcept C162324750 @default.
- W4289012803 hasConcept C169900460 @default.
- W4289012803 hasConcept C1862650 @default.
- W4289012803 hasConcept C23131810 @default.
- W4289012803 hasConcept C2776867660 @default.
- W4289012803 hasConcept C2778227246 @default.
- W4289012803 hasConcept C2779951463 @default.
- W4289012803 hasConcept C2780733359 @default.
- W4289012803 hasConcept C502942594 @default.
- W4289012803 hasConcept C70410870 @default.
- W4289012803 hasConcept C71924100 @default.
- W4289012803 hasConceptScore W4289012803C118552586 @default.
- W4289012803 hasConceptScore W4289012803C126322002 @default.
- W4289012803 hasConceptScore W4289012803C137627325 @default.
- W4289012803 hasConceptScore W4289012803C139719470 @default.
- W4289012803 hasConceptScore W4289012803C159110408 @default.
- W4289012803 hasConceptScore W4289012803C162324750 @default.
- W4289012803 hasConceptScore W4289012803C169900460 @default.
- W4289012803 hasConceptScore W4289012803C1862650 @default.
- W4289012803 hasConceptScore W4289012803C23131810 @default.
- W4289012803 hasConceptScore W4289012803C2776867660 @default.
- W4289012803 hasConceptScore W4289012803C2778227246 @default.
- W4289012803 hasConceptScore W4289012803C2779951463 @default.
- W4289012803 hasConceptScore W4289012803C2780733359 @default.
- W4289012803 hasConceptScore W4289012803C502942594 @default.
- W4289012803 hasConceptScore W4289012803C70410870 @default.
- W4289012803 hasConceptScore W4289012803C71924100 @default.
- W4289012803 hasLocation W42890128031 @default.