FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289109250> ?p ?o ?g. }

• W4289109250 endingPage "605" @default.
• W4289109250 startingPage "590" @default.
• W4289109250 abstract "Abstract Mast cells (MCs), central players in allergy and parasitic infections, play key roles in inflammation and fibrosis. Here, the impact of MCs on the progression of Coxsackievirus B3 (CVB3)‐induced viral myocarditis (VMC) and fibrosis was investigated using MC‐deficient Kit W‐sh mice. Viral titres, cellular infiltrates and heart pathologies were evaluated and compared with wild‐type (WT) mice during acute CVB3 infection of C57BL/6 mice. CVB3 infection induced an increased accumulation and degranulation of MCs in the hearts of mice during acute infection. MC‐deficient Kit W‐sh mice had slightly higher viral titres, decreased VMC and cardiac fibrosis and improved cardiac dysfunction compared to WT mice via decreasing cardiac influx of Ly6C high monocytes/macrophages (Mo/M φ ). While bone marrow‐derived MC reconstitution decreased viral titre and worsened improved survival and VMC severity in Wsh mice. MC‐fibroblasts co‐culture revealed a cardiac MC‐fibroblasts crosstalk during early infection: fibroblasts trigger MC degranulation and secretion of CCL2 and tumour necrosis factor alpha (TNF‐α) via producing early stem cell factor (SCF); while MCs‐fibrogenic mediators (TNF‐α) stimulate fibroblasts to increase CCL2, α‐smooth muscle actin (SMA), collagen and transforming growth factor beta（TGFβ) expression, thus aggravating cardiac fibrosis. MCs and fibroblast‐derived CCL2s are both essential for cardiac Ly6C high Mo/M φ influx. Administration of recombinant mouse SCF to CVB3‐infected mice aggravates VMC via accelerating MCs accumulation and cardiac influx of Ly6C hi Mo/M φ . Collectively, our data highlight an early MC‐fibroblast crosstalk and SCF/MC/CCL2/Mo/M φ axis as important mechanisms required for triggering VMC and myocardial fibrosis. This finding indicates critical roles of MCs in initiating and modulating cardiac innate response to CVB3 and has an implication in developing new and more effective treatments for VMC." @default.
• W4289109250 created "2022-08-01" @default.
• W4289109250 creator A5014355203 @default.
• W4289109250 creator A5014894920 @default.
• W4289109250 creator A5028430046 @default.
• W4289109250 creator A5052024256 @default.
• W4289109250 creator A5059955952 @default.
• W4289109250 creator A5086595514 @default.
• W4289109250 date "2022-08-23" @default.
• W4289109250 modified "2023-10-16" @default.
• W4289109250 title "Stem cell factor/mast cell/<scp>CCL2</scp>/monocyte/macrophage axis promotes Coxsackievirus B3 myocarditis and cardiac fibrosis by increasing <scp>Ly6C^high</scp> monocyte influx and fibrogenic mediators production" @default.
• W4289109250 cites W1519095934 @default.
• W4289109250 cites W1608006172 @default.
• W4289109250 cites W1687028806 @default.
• W4289109250 cites W1792432231 @default.
• W4289109250 cites W1806230168 @default.
• W4289109250 cites W1917885467 @default.
• W4289109250 cites W1981635815 @default.
• W4289109250 cites W1995787836 @default.
• W4289109250 cites W2012664798 @default.
• W4289109250 cites W2016233078 @default.
• W4289109250 cites W2025509139 @default.
• W4289109250 cites W2033723439 @default.
• W4289109250 cites W2036872855 @default.
• W4289109250 cites W2065484232 @default.
• W4289109250 cites W2067754406 @default.
• W4289109250 cites W2068899291 @default.
• W4289109250 cites W2073635196 @default.
• W4289109250 cites W2083467607 @default.
• W4289109250 cites W2085467917 @default.
• W4289109250 cites W2106301295 @default.
• W4289109250 cites W2126464451 @default.
• W4289109250 cites W2133832773 @default.
• W4289109250 cites W2145420458 @default.
• W4289109250 cites W2147100898 @default.
• W4289109250 cites W2147286447 @default.
• W4289109250 cites W2157962982 @default.
• W4289109250 cites W2163111319 @default.
• W4289109250 cites W2244716392 @default.
• W4289109250 cites W2254623601 @default.
• W4289109250 cites W2273527755 @default.
• W4289109250 cites W2301627940 @default.
• W4289109250 cites W2312220900 @default.
• W4289109250 cites W2396923175 @default.
• W4289109250 cites W2443773017 @default.
• W4289109250 cites W2470531925 @default.
• W4289109250 cites W2515627479 @default.
• W4289109250 cites W2608913882 @default.
• W4289109250 cites W2610307528 @default.
• W4289109250 cites W2625029054 @default.
• W4289109250 cites W2763338820 @default.
• W4289109250 cites W2782228712 @default.
• W4289109250 cites W2785541210 @default.
• W4289109250 cites W2791242949 @default.
• W4289109250 cites W2800188894 @default.
• W4289109250 cites W2803906736 @default.
• W4289109250 cites W2804972113 @default.
• W4289109250 cites W2900494912 @default.
• W4289109250 cites W2919852644 @default.
• W4289109250 cites W2949621837 @default.
• W4289109250 cites W2961736444 @default.
• W4289109250 cites W2964547467 @default.
• W4289109250 cites W3005414324 @default.
• W4289109250 cites W3019563208 @default.
• W4289109250 cites W3036136186 @default.
• W4289109250 cites W3038076751 @default.
• W4289109250 cites W3045497278 @default.
• W4289109250 cites W4211100931 @default.
• W4289109250 cites W4211186615 @default.
• W4289109250 cites W4240413437 @default.
• W4289109250 cites W4253834565 @default.
• W4289109250 doi "https://doi.org/10.1111/imm.13556" @default.
• W4289109250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36054617" @default.
• W4289109250 hasPublicationYear "2022" @default.
• W4289109250 type Work @default.
• W4289109250 citedByCount "4" @default.
• W4289109250 countsByYear W42891092502022 @default.
• W4289109250 countsByYear W42891092502023 @default.
• W4289109250 crossrefType "journal-article" @default.
• W4289109250 hasAuthorship W4289109250A5014355203 @default.
• W4289109250 hasAuthorship W4289109250A5014894920 @default.
• W4289109250 hasAuthorship W4289109250A5028430046 @default.
• W4289109250 hasAuthorship W4289109250A5052024256 @default.
• W4289109250 hasAuthorship W4289109250A5059955952 @default.
• W4289109250 hasAuthorship W4289109250A5086595514 @default.
• W4289109250 hasConcept C101666144 @default.
• W4289109250 hasConcept C109159458 @default.
• W4289109250 hasConcept C126322002 @default.
• W4289109250 hasConcept C13373296 @default.
• W4289109250 hasConcept C142724271 @default.
• W4289109250 hasConcept C170493617 @default.
• W4289109250 hasConcept C17991360 @default.
• W4289109250 hasConcept C2022786 @default.
• W4289109250 hasConcept C203014093 @default.
• W4289109250 hasConcept C2776914184 @default.
• W4289109250 hasConcept C2777420927 @default.
• W4289109250 hasConcept C2778690821 @default.
• W4289109250 hasConcept C2779726688 @default.

• next