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- W4289131857 startingPage "9398" @default.
- W4289131857 abstract "Multiple studies imply a strong relationship between global warming (GW) and complex disorders. This review summarizes such reports concentrating on three disorders—mental disorders (MD), primary hypertension, and type 2 diabetes (T2D). We also attempt to point at potential mechanisms mediating the effect of GW on these disorders. Concerning mental disorders, immediate candidates are brain levels of heat-shock proteins (HSPs). In addition, given that heat stress increases reactive oxygen species (ROS) levels which may lead to blood–brain barrier (BBB) breakdown and, hence, enhanced protein extravasation in the brain, this might finally cause, or exacerbate mental health. As for hypertension, since its causes are incompletely understood, the mechanism(s) by which heat exposure affects blood pressure (BP) is an open question. Since the kidneys participate in regulating blood volume and BP they are considered as a site of heat-associated disease, hence, we discuss hyperosmolarity as a potential mediator. In addition, we relate to autoimmunity, inflammation, sodium excretion, and HSP70 as risk factors that might play a role in the effect of heat on hypertension. In the case of T2D, we raise two potential mediators of the effect of exposure to ambient hot environment on the disease’s incidence—brown adipose tissue metabolism and HSPs." @default.
- W4289131857 created "2022-08-01" @default.
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- W4289131857 date "2022-07-31" @default.
- W4289131857 modified "2023-10-18" @default.
- W4289131857 title "The Effect of Global Warming on Complex Disorders (Mental Disorders, Primary Hypertension, and Type 2 Diabetes)" @default.
- W4289131857 cites W1070541438 @default.
- W4289131857 cites W1489055978 @default.
- W4289131857 cites W1493831502 @default.
- W4289131857 cites W1523213544 @default.
- W4289131857 cites W1529373620 @default.
- W4289131857 cites W1543001415 @default.
- W4289131857 cites W1557434140 @default.
- W4289131857 cites W1575488422 @default.
- W4289131857 cites W1596244991 @default.
- W4289131857 cites W1599595176 @default.
- W4289131857 cites W1969434818 @default.
- W4289131857 cites W1970325984 @default.
- W4289131857 cites W1971094372 @default.
- W4289131857 cites W1998045944 @default.
- W4289131857 cites W2032739238 @default.
- W4289131857 cites W2040359453 @default.
- W4289131857 cites W2050160473 @default.
- W4289131857 cites W2051811506 @default.
- W4289131857 cites W2053208961 @default.
- W4289131857 cites W2060832991 @default.
- W4289131857 cites W2064985419 @default.
- W4289131857 cites W2066690328 @default.
- W4289131857 cites W2070851068 @default.
- W4289131857 cites W2073576822 @default.
- W4289131857 cites W2079749544 @default.
- W4289131857 cites W2080382440 @default.
- W4289131857 cites W2085157974 @default.
- W4289131857 cites W2090931595 @default.
- W4289131857 cites W2092187827 @default.
- W4289131857 cites W2101967150 @default.
- W4289131857 cites W2110840270 @default.
- W4289131857 cites W2114423803 @default.
- W4289131857 cites W2122492614 @default.
- W4289131857 cites W2160488592 @default.
- W4289131857 cites W2161551760 @default.
- W4289131857 cites W2171655622 @default.
- W4289131857 cites W2238434403 @default.
- W4289131857 cites W2332093978 @default.
- W4289131857 cites W2345489509 @default.
- W4289131857 cites W2433156538 @default.
- W4289131857 cites W2511670019 @default.
- W4289131857 cites W2530588595 @default.
- W4289131857 cites W2594891680 @default.
- W4289131857 cites W2598571027 @default.
- W4289131857 cites W2604864169 @default.
- W4289131857 cites W2619810380 @default.
- W4289131857 cites W2626648542 @default.
- W4289131857 cites W2735353917 @default.
- W4289131857 cites W2770506771 @default.
- W4289131857 cites W2803079201 @default.
- W4289131857 cites W2805155961 @default.
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- W4289131857 cites W2807705809 @default.
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- W4289131857 cites W2892838714 @default.
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- W4289131857 cites W2907520835 @default.
- W4289131857 cites W2949104016 @default.
- W4289131857 cites W2955250458 @default.
- W4289131857 cites W2955558484 @default.
- W4289131857 cites W2978440366 @default.
- W4289131857 cites W2990128071 @default.
- W4289131857 cites W2990861551 @default.
- W4289131857 cites W2994822050 @default.
- W4289131857 cites W2995581566 @default.
- W4289131857 cites W3009280600 @default.
- W4289131857 cites W3013352992 @default.
- W4289131857 cites W3081655479 @default.
- W4289131857 cites W3083471600 @default.
- W4289131857 cites W3103603843 @default.
- W4289131857 cites W3112138799 @default.
- W4289131857 cites W3121438048 @default.
- W4289131857 cites W3164570271 @default.
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- W4289131857 cites W391810772 @default.
- W4289131857 cites W4253107192 @default.
- W4289131857 cites W4254257178 @default.
- W4289131857 cites W643962955 @default.
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- W4289131857 doi "https://doi.org/10.3390/ijerph19159398" @default.
- W4289131857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35954764" @default.
- W4289131857 hasPublicationYear "2022" @default.
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