Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289169871> ?p ?o ?g. }
- W4289169871 abstract "Viruses that infect bacteria (i.e., phages) are abundant and widespread in the human body, and new anti-infective approaches such as phage therapy are essential for the future of effective medicine. Our understanding of microenvironmental factors such as tissue oxygen availability at the site of phage-bacteria interaction remains limited, and it is unknown whether evolved resistance is sculpted differentially under normoxia vs. hypoxia. We, therefore, analyzed the phage-bacteria interaction landscape via adsorption, one-step, time-kill dynamics, and genetic evolution under both normoxia and hypoxia. This revealed that adsorption of phages to Pseudomonas aeruginosa decreased under 14% environmental oxygen (i.e., hypoxia), but phage time-kill and one-step growth kinetics were not further influenced. Tracking the adaptation of P. aeruginosa to phages uncovered a higher frequency of phage resistance and constrained types of spontaneous mutation under hypoxia. Given the interest in developing phage therapies, developing our understanding of the phage-pathogen interaction under microenvironmental conditions resembling those in the body offers insight into possible strategies to overcome multidrug-resistant (MDR) bacteria." @default.
- W4289169871 created "2022-08-01" @default.
- W4289169871 creator A5045322462 @default.
- W4289169871 creator A5068199608 @default.
- W4289169871 creator A5089913383 @default.
- W4289169871 date "2022-08-01" @default.
- W4289169871 modified "2023-09-27" @default.
- W4289169871 title "Hypoxia Increases the Tempo of Phage Resistance and Mutational Bottlenecking of Pseudomonas aeruginosa" @default.
- W4289169871 cites W129814170 @default.
- W4289169871 cites W1487286491 @default.
- W4289169871 cites W2000058195 @default.
- W4289169871 cites W2003670869 @default.
- W4289169871 cites W2005561077 @default.
- W4289169871 cites W2015905438 @default.
- W4289169871 cites W2019197162 @default.
- W4289169871 cites W2037221728 @default.
- W4289169871 cites W2040676946 @default.
- W4289169871 cites W2041942886 @default.
- W4289169871 cites W2049995353 @default.
- W4289169871 cites W2099798492 @default.
- W4289169871 cites W2110104778 @default.
- W4289169871 cites W2113079985 @default.
- W4289169871 cites W2116228267 @default.
- W4289169871 cites W2121890764 @default.
- W4289169871 cites W2122596809 @default.
- W4289169871 cites W2133164395 @default.
- W4289169871 cites W2137661621 @default.
- W4289169871 cites W2139228861 @default.
- W4289169871 cites W2142428670 @default.
- W4289169871 cites W2163435738 @default.
- W4289169871 cites W2290768068 @default.
- W4289169871 cites W2345969757 @default.
- W4289169871 cites W2407344160 @default.
- W4289169871 cites W2588657365 @default.
- W4289169871 cites W2601192980 @default.
- W4289169871 cites W2735330212 @default.
- W4289169871 cites W2740172058 @default.
- W4289169871 cites W2772066286 @default.
- W4289169871 cites W2792108714 @default.
- W4289169871 cites W2793753655 @default.
- W4289169871 cites W2886137859 @default.
- W4289169871 cites W2912134343 @default.
- W4289169871 cites W2943878465 @default.
- W4289169871 cites W2947765278 @default.
- W4289169871 cites W3004580216 @default.
- W4289169871 cites W3036135788 @default.
- W4289169871 cites W3041631246 @default.
- W4289169871 cites W3044113171 @default.
- W4289169871 cites W3045043630 @default.
- W4289169871 cites W3045118558 @default.
- W4289169871 cites W3082973737 @default.
- W4289169871 cites W3088852203 @default.
- W4289169871 cites W3118458503 @default.
- W4289169871 cites W3125525850 @default.
- W4289169871 cites W3135311643 @default.
- W4289169871 cites W3137034646 @default.
- W4289169871 cites W3163630165 @default.
- W4289169871 cites W3172541449 @default.
- W4289169871 cites W3195166090 @default.
- W4289169871 cites W4210696514 @default.
- W4289169871 doi "https://doi.org/10.3389/fmicb.2022.905343" @default.
- W4289169871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35979493" @default.
- W4289169871 hasPublicationYear "2022" @default.
- W4289169871 type Work @default.
- W4289169871 citedByCount "1" @default.
- W4289169871 countsByYear W42891698712023 @default.
- W4289169871 crossrefType "journal-article" @default.
- W4289169871 hasAuthorship W4289169871A5045322462 @default.
- W4289169871 hasAuthorship W4289169871A5068199608 @default.
- W4289169871 hasAuthorship W4289169871A5089913383 @default.
- W4289169871 hasBestOaLocation W42891698711 @default.
- W4289169871 hasConcept C104317684 @default.
- W4289169871 hasConcept C2776441376 @default.
- W4289169871 hasConcept C2777637488 @default.
- W4289169871 hasConcept C2779256223 @default.
- W4289169871 hasConcept C2780984408 @default.
- W4289169871 hasConcept C523546767 @default.
- W4289169871 hasConcept C54355233 @default.
- W4289169871 hasConcept C547475151 @default.
- W4289169871 hasConcept C86803240 @default.
- W4289169871 hasConcept C89423630 @default.
- W4289169871 hasConceptScore W4289169871C104317684 @default.
- W4289169871 hasConceptScore W4289169871C2776441376 @default.
- W4289169871 hasConceptScore W4289169871C2777637488 @default.
- W4289169871 hasConceptScore W4289169871C2779256223 @default.
- W4289169871 hasConceptScore W4289169871C2780984408 @default.
- W4289169871 hasConceptScore W4289169871C523546767 @default.
- W4289169871 hasConceptScore W4289169871C54355233 @default.
- W4289169871 hasConceptScore W4289169871C547475151 @default.
- W4289169871 hasConceptScore W4289169871C86803240 @default.
- W4289169871 hasConceptScore W4289169871C89423630 @default.
- W4289169871 hasLocation W42891698711 @default.
- W4289169871 hasLocation W42891698712 @default.
- W4289169871 hasLocation W42891698713 @default.
- W4289169871 hasLocation W42891698714 @default.
- W4289169871 hasOpenAccess W4289169871 @default.
- W4289169871 hasPrimaryLocation W42891698711 @default.
- W4289169871 hasRelatedWork W2626389736 @default.
- W4289169871 hasRelatedWork W2893337201 @default.
- W4289169871 hasRelatedWork W2918569058 @default.