Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289170390> ?p ?o ?g. }
- W4289170390 endingPage "138421" @default.
- W4289170390 startingPage "138421" @default.
- W4289170390 abstract "• Pt-PNA was first developed as RF-responsive embolic nano-platform. • Pt-PNA diffuse rapidly into tumor peripheral arteries and block the tumor blood. • Pt-PNA is a nano-platform for efficiently synergizing various therapeutic models. • Pt-PNA greatly induced a favorable immune response. Improving the synergistic effect of radiofrequency ablation (RFA) and trans-artery chemo-embolization (TACE) remains the main challenge in interventional cancer therapy. The present study reports cisplatin-crosslinking poly(N-isoprylacrylamide- b -methyl acrylic acid) nanogels (Pt-PNA) based on the RF-thermal effect of cisplatin as the RF-responsive embolic nano-platform that acts via coordination bonding between Pt(II) ions and carboxyl, thereby triggering cell apoptosis, necrosis, and metastasis inhibition. Moreover, Pt-PNA might diffuse rapidly into tumor peripheral arteries and block the tumor blood supply facilitated by temperature-sensitive sol-gel transition, thereby achieving efficient TACE cancer therapy. The antitumor efficacy exhibited in vivo by Pt-PNA indicated that the radiofrequency-responsive Pt-PNA greatly improved the hypoxic tumor microenvironment after the TAE procedure, thereby inducing a favorable immune response and enhancing the synergistic antitumor effect of RFA and TACE." @default.
- W4289170390 created "2022-08-01" @default.
- W4289170390 creator A5007009932 @default.
- W4289170390 creator A5022504253 @default.
- W4289170390 creator A5027041701 @default.
- W4289170390 creator A5029849389 @default.
- W4289170390 creator A5058286538 @default.
- W4289170390 creator A5072861069 @default.
- W4289170390 creator A5088695873 @default.
- W4289170390 date "2022-12-01" @default.
- W4289170390 modified "2023-10-16" @default.
- W4289170390 title "Radiofrequency-thermal effect of cisplatin-crosslinked nanogels for triple therapies of ablation-chemo-embolization" @default.
- W4289170390 cites W1946228183 @default.
- W4289170390 cites W1982607521 @default.
- W4289170390 cites W1996703005 @default.
- W4289170390 cites W2000761093 @default.
- W4289170390 cites W2018166691 @default.
- W4289170390 cites W2022881840 @default.
- W4289170390 cites W2023195241 @default.
- W4289170390 cites W2023250239 @default.
- W4289170390 cites W2026961979 @default.
- W4289170390 cites W2032224733 @default.
- W4289170390 cites W2032349276 @default.
- W4289170390 cites W2041874306 @default.
- W4289170390 cites W2042669918 @default.
- W4289170390 cites W2068127752 @default.
- W4289170390 cites W2068424305 @default.
- W4289170390 cites W2070150128 @default.
- W4289170390 cites W2072626928 @default.
- W4289170390 cites W2084403720 @default.
- W4289170390 cites W2093762704 @default.
- W4289170390 cites W2104329903 @default.
- W4289170390 cites W2110960007 @default.
- W4289170390 cites W2113382418 @default.
- W4289170390 cites W2113597085 @default.
- W4289170390 cites W2114611853 @default.
- W4289170390 cites W2115991409 @default.
- W4289170390 cites W2126193697 @default.
- W4289170390 cites W2129166766 @default.
- W4289170390 cites W2129802218 @default.
- W4289170390 cites W2131935157 @default.
- W4289170390 cites W2133953792 @default.
- W4289170390 cites W2153468600 @default.
- W4289170390 cites W2163654664 @default.
- W4289170390 cites W2169808388 @default.
- W4289170390 cites W2172053487 @default.
- W4289170390 cites W2174814098 @default.
- W4289170390 cites W2208538179 @default.
- W4289170390 cites W2277004004 @default.
- W4289170390 cites W2328807106 @default.
- W4289170390 cites W2340636398 @default.
- W4289170390 cites W2396642357 @default.
- W4289170390 cites W2410208054 @default.
- W4289170390 cites W2469003638 @default.
- W4289170390 cites W2564004426 @default.
- W4289170390 cites W2605278786 @default.
- W4289170390 cites W2617251623 @default.
- W4289170390 cites W2806609236 @default.
- W4289170390 cites W2910282721 @default.
- W4289170390 cites W2950572539 @default.
- W4289170390 cites W2969669884 @default.
- W4289170390 cites W3044142551 @default.
- W4289170390 cites W4245784696 @default.
- W4289170390 cites W4252851641 @default.
- W4289170390 doi "https://doi.org/10.1016/j.cej.2022.138421" @default.
- W4289170390 hasPublicationYear "2022" @default.
- W4289170390 type Work @default.
- W4289170390 citedByCount "3" @default.
- W4289170390 countsByYear W42891703902023 @default.
- W4289170390 crossrefType "journal-article" @default.
- W4289170390 hasAuthorship W4289170390A5007009932 @default.
- W4289170390 hasAuthorship W4289170390A5022504253 @default.
- W4289170390 hasAuthorship W4289170390A5027041701 @default.
- W4289170390 hasAuthorship W4289170390A5029849389 @default.
- W4289170390 hasAuthorship W4289170390A5058286538 @default.
- W4289170390 hasAuthorship W4289170390A5072861069 @default.
- W4289170390 hasAuthorship W4289170390A5088695873 @default.
- W4289170390 hasConcept C126322002 @default.
- W4289170390 hasConcept C141071460 @default.
- W4289170390 hasConcept C185592680 @default.
- W4289170390 hasConcept C192562407 @default.
- W4289170390 hasConcept C2776035437 @default.
- W4289170390 hasConcept C2776694085 @default.
- W4289170390 hasConcept C2777377203 @default.
- W4289170390 hasConcept C2778239845 @default.
- W4289170390 hasConcept C2778902805 @default.
- W4289170390 hasConcept C2992234517 @default.
- W4289170390 hasConcept C71924100 @default.
- W4289170390 hasConceptScore W4289170390C126322002 @default.
- W4289170390 hasConceptScore W4289170390C141071460 @default.
- W4289170390 hasConceptScore W4289170390C185592680 @default.
- W4289170390 hasConceptScore W4289170390C192562407 @default.
- W4289170390 hasConceptScore W4289170390C2776035437 @default.
- W4289170390 hasConceptScore W4289170390C2776694085 @default.
- W4289170390 hasConceptScore W4289170390C2777377203 @default.
- W4289170390 hasConceptScore W4289170390C2778239845 @default.
- W4289170390 hasConceptScore W4289170390C2778902805 @default.
- W4289170390 hasConceptScore W4289170390C2992234517 @default.