Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289175090> ?p ?o ?g. }
- W4289175090 endingPage "8448" @default.
- W4289175090 startingPage "8448" @default.
- W4289175090 abstract "(1) Background: Extracellular signal-regulating kinase 5 (ERK5) has been implicated in many cellular functions, including survival, proliferation, and vascularization. Our objectives were to examine the expression and effect of ERK5 in clear cell renal cell carcinoma (ccRCC). (2) Methods: The expressions of ERK5 and its regulating micro-RNA miR-143 were investigated using immunohistochemistry and quantitative reverse transcriptase PCR in surgical specimens of ccRCC patients. With invitro and in vivo studies, we used pharmacologic ERK5 inhibitor XMD8-92, RNA interference, pre-miR-143 transduction, Western blotting, MTS assay, apoptosis assay, and subcutaneous xenograft model. (3) Results: A strong ERK5 expression in surgical specimen was associated with high-grade (p = 0.01), high-recurrence free rate (p = 0.02), and high cancer-specific survival (p = 0.03). Expression levels of ERK5 and miR-143 expression level were correlated (p = 0.049). Pre-miR-143 transduction into ccRCC cell A498 suppressed ERK5 expression. ERK5 inhibition enhanced cyclin-dependent kinase inhibitor p21 expression and decreased anti-apoptotic molecules BCL2, resulting in decreased cell proliferation and survival both in ccRCC and endothelial cells. In the xenograft model, ERK5 inhibitor XMD8-92 suppressed tumor growth. (4) Conclusions: ERK5 is regulated by miR-143, and ERK5 inhibition is a promising target for ccRCC treatment." @default.
- W4289175090 created "2022-08-01" @default.
- W4289175090 creator A5010300952 @default.
- W4289175090 creator A5011987568 @default.
- W4289175090 creator A5020087597 @default.
- W4289175090 creator A5023764914 @default.
- W4289175090 creator A5024597836 @default.
- W4289175090 creator A5027892519 @default.
- W4289175090 creator A5047953305 @default.
- W4289175090 creator A5052645092 @default.
- W4289175090 creator A5055477590 @default.
- W4289175090 date "2022-07-30" @default.
- W4289175090 modified "2023-10-17" @default.
- W4289175090 title "Effect of Extracellular Signal-Regulated Protein Kinase 5 Inhibition in Clear Cell Renal Cell Carcinoma" @default.
- W4289175090 cites W1184209146 @default.
- W4289175090 cites W1880561744 @default.
- W4289175090 cites W1932917546 @default.
- W4289175090 cites W1971358860 @default.
- W4289175090 cites W1972511274 @default.
- W4289175090 cites W1987328298 @default.
- W4289175090 cites W1991972495 @default.
- W4289175090 cites W1993966052 @default.
- W4289175090 cites W2013463734 @default.
- W4289175090 cites W2024955968 @default.
- W4289175090 cites W2025795146 @default.
- W4289175090 cites W2029581055 @default.
- W4289175090 cites W2031563027 @default.
- W4289175090 cites W2033830808 @default.
- W4289175090 cites W2035687698 @default.
- W4289175090 cites W2037090973 @default.
- W4289175090 cites W2040652561 @default.
- W4289175090 cites W2041502163 @default.
- W4289175090 cites W2056241456 @default.
- W4289175090 cites W2057379482 @default.
- W4289175090 cites W2066604995 @default.
- W4289175090 cites W2069981394 @default.
- W4289175090 cites W2082633239 @default.
- W4289175090 cites W2092050888 @default.
- W4289175090 cites W2096172976 @default.
- W4289175090 cites W2096948402 @default.
- W4289175090 cites W2101918466 @default.
- W4289175090 cites W2102449319 @default.
- W4289175090 cites W2103413154 @default.
- W4289175090 cites W2103823463 @default.
- W4289175090 cites W2107277218 @default.
- W4289175090 cites W2109838780 @default.
- W4289175090 cites W2115728951 @default.
- W4289175090 cites W2127971712 @default.
- W4289175090 cites W2134468110 @default.
- W4289175090 cites W2139205106 @default.
- W4289175090 cites W2178888418 @default.
- W4289175090 cites W2184194602 @default.
- W4289175090 cites W2192080449 @default.
- W4289175090 cites W2212528925 @default.
- W4289175090 cites W2284518822 @default.
- W4289175090 cites W2484295046 @default.
- W4289175090 cites W2515510347 @default.
- W4289175090 cites W2564319579 @default.
- W4289175090 cites W2619013431 @default.
- W4289175090 cites W2735696766 @default.
- W4289175090 cites W2736159529 @default.
- W4289175090 cites W2808537193 @default.
- W4289175090 cites W2883572600 @default.
- W4289175090 cites W2921030235 @default.
- W4289175090 cites W2965642340 @default.
- W4289175090 doi "https://doi.org/10.3390/ijms23158448" @default.
- W4289175090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35955582" @default.
- W4289175090 hasPublicationYear "2022" @default.
- W4289175090 type Work @default.
- W4289175090 citedByCount "1" @default.
- W4289175090 countsByYear W42891750902023 @default.
- W4289175090 crossrefType "journal-article" @default.
- W4289175090 hasAuthorship W4289175090A5010300952 @default.
- W4289175090 hasAuthorship W4289175090A5011987568 @default.
- W4289175090 hasAuthorship W4289175090A5020087597 @default.
- W4289175090 hasAuthorship W4289175090A5023764914 @default.
- W4289175090 hasAuthorship W4289175090A5024597836 @default.
- W4289175090 hasAuthorship W4289175090A5027892519 @default.
- W4289175090 hasAuthorship W4289175090A5047953305 @default.
- W4289175090 hasAuthorship W4289175090A5052645092 @default.
- W4289175090 hasAuthorship W4289175090A5055477590 @default.
- W4289175090 hasBestOaLocation W42891750901 @default.
- W4289175090 hasConcept C142724271 @default.
- W4289175090 hasConcept C1491633281 @default.
- W4289175090 hasConcept C153911025 @default.
- W4289175090 hasConcept C184235292 @default.
- W4289175090 hasConcept C185592680 @default.
- W4289175090 hasConcept C190283241 @default.
- W4289175090 hasConcept C204232928 @default.
- W4289175090 hasConcept C2777472916 @default.
- W4289175090 hasConcept C2781278892 @default.
- W4289175090 hasConcept C28406088 @default.
- W4289175090 hasConcept C502942594 @default.
- W4289175090 hasConcept C55493867 @default.
- W4289175090 hasConcept C62112901 @default.
- W4289175090 hasConcept C62478195 @default.
- W4289175090 hasConcept C71924100 @default.
- W4289175090 hasConcept C86803240 @default.