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- W4289201620 startingPage "1848" @default.
- W4289201620 abstract "Erectile dysfunction (ED) is a condition with multifactorial pathogenesis, quite common among men, especially those above 60 years old. A vascular etiology is the most common cause. The interaction between chronic inflammation, androgens, and cardiovascular risk factors determines macroscopically invisible alterations such as endothelial dysfunction and subsequent atherosclerosis and flow-limiting stenosis that affects both penile and coronary arteries. Thus, ED and cardiovascular disease (CVD) should be considered two different manifestations of the same systemic disorder, with a shared aetiological factor being endothelial dysfunction. Moreover, the penile arteries have a smaller size compared with coronary arteries; thus, for the same level of arteriopathy, a more significant blood flow reduction will occur in erectile tissue compared with coronary circulation. As a result, ED often precedes CVD by 2–5 years, and its diagnosis offers a time window for cardiovascular risk mitigation. Growing evidence suggests, in fact, that patients presenting with ED should be investigated for CVD even if they have no symptoms. Early detection could facilitate prompt intervention and a reduction in long-term complications. In this review, we provide an overview of the pathogenetic mechanisms behind arteriogenic ED and CVD, focusing on the role of endothelial dysfunction as the common denominator of the two disorders. Developed algorithms that may help identify those patients complaining of ED who should undergo detailed cardiologic assessment and receive intensive treatment for risk factors are also analyzed." @default.
- W4289201620 created "2022-08-01" @default.
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- W4289201620 date "2022-08-01" @default.
- W4289201620 modified "2023-10-09" @default.
- W4289201620 title "Endothelial Dysfunction, Erectile Deficit and Cardiovascular Disease: An Overview of the Pathogenetic Links" @default.
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- W4289201620 cites W1528557278 @default.
- W4289201620 cites W163162712 @default.
- W4289201620 cites W176571599 @default.
- W4289201620 cites W1827562163 @default.
- W4289201620 cites W1963798910 @default.
- W4289201620 cites W1966150385 @default.
- W4289201620 cites W1966415714 @default.
- W4289201620 cites W1968181857 @default.
- W4289201620 cites W1970513210 @default.
- W4289201620 cites W1992718978 @default.
- W4289201620 cites W1997623828 @default.
- W4289201620 cites W2002094956 @default.
- W4289201620 cites W2004679365 @default.
- W4289201620 cites W2009918830 @default.
- W4289201620 cites W2010543425 @default.
- W4289201620 cites W2011243033 @default.
- W4289201620 cites W2025002838 @default.
- W4289201620 cites W2027428229 @default.
- W4289201620 cites W2034320103 @default.
- W4289201620 cites W2035279715 @default.
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- W4289201620 cites W2045669438 @default.
- W4289201620 cites W2046176923 @default.
- W4289201620 cites W2054526635 @default.
- W4289201620 cites W2063167222 @default.
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- W4289201620 cites W2072472407 @default.
- W4289201620 cites W2073526291 @default.
- W4289201620 cites W2077462073 @default.
- W4289201620 cites W2078718611 @default.
- W4289201620 cites W2091118913 @default.
- W4289201620 cites W2098657147 @default.
- W4289201620 cites W2103154123 @default.
- W4289201620 cites W2114099957 @default.
- W4289201620 cites W2117467286 @default.
- W4289201620 cites W2123746469 @default.
- W4289201620 cites W2124249612 @default.
- W4289201620 cites W2130863113 @default.
- W4289201620 cites W2131615503 @default.
- W4289201620 cites W2137904526 @default.
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- W4289201620 cites W2143959240 @default.
- W4289201620 cites W2148436434 @default.
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- W4289201620 cites W2162919082 @default.
- W4289201620 cites W2171236476 @default.
- W4289201620 cites W2183059006 @default.
- W4289201620 cites W2297358297 @default.
- W4289201620 cites W2557482494 @default.
- W4289201620 cites W2618596952 @default.
- W4289201620 cites W2725108908 @default.
- W4289201620 cites W281105627 @default.
- W4289201620 cites W2888025232 @default.
- W4289201620 cites W3007962112 @default.
- W4289201620 cites W3100532322 @default.
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- W4289201620 doi "https://doi.org/10.3390/biomedicines10081848" @default.
- W4289201620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36009395" @default.
- W4289201620 hasPublicationYear "2022" @default.
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