Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289202352> ?p ?o ?g. }
- W4289202352 abstract "Abstract A clear and precise report on synthetic methods for INSTIs and their intermediates are provided in the present work. HIV Integrase strand transfer inhibitors (INSTIs), a class of antiretroviral agents employed to treat HIV infected patients are placed as the second option of treatment after nucleosides. As INSTIs are employed as first line therapy to newly infected HIV positive individuals, thus synthetic routes must be easily accessible to the medicinal chemists towards lead optimization or process development. The current perspective elaborates synthetic routes of first to next generation INSTIs investigated in two decades of research and their development efforts. Further, drug resistance occurred by mutations against usage of INSTI drugs with respect to their generation also discussed. Later, discussion about synthetic development and investigation of next generation INSTIs against drug resistance HIV infections also covers to fill the gap between first/second generation INSTIs. The current perspective will draw attention of medicinal chemists and multi‐disciplinary researchers in HIV drug discovery." @default.
- W4289202352 created "2022-08-01" @default.
- W4289202352 creator A5014025952 @default.
- W4289202352 creator A5023193536 @default.
- W4289202352 creator A5058895780 @default.
- W4289202352 creator A5084854319 @default.
- W4289202352 date "2022-08-01" @default.
- W4289202352 modified "2023-09-26" @default.
- W4289202352 title "Development of Synthetic Approaches Towards HIV Integrase Strand Transfer Inhibitors (INSTIs)" @default.
- W4289202352 cites W1562621350 @default.
- W4289202352 cites W1965497780 @default.
- W4289202352 cites W1966808583 @default.
- W4289202352 cites W1968359293 @default.
- W4289202352 cites W1969831680 @default.
- W4289202352 cites W1970034671 @default.
- W4289202352 cites W1978964531 @default.
- W4289202352 cites W1979989142 @default.
- W4289202352 cites W1985667653 @default.
- W4289202352 cites W1989172083 @default.
- W4289202352 cites W1990789059 @default.
- W4289202352 cites W2004824357 @default.
- W4289202352 cites W2008162319 @default.
- W4289202352 cites W2012527357 @default.
- W4289202352 cites W2012607545 @default.
- W4289202352 cites W2020258510 @default.
- W4289202352 cites W2025444624 @default.
- W4289202352 cites W2032136448 @default.
- W4289202352 cites W2043284110 @default.
- W4289202352 cites W2068095506 @default.
- W4289202352 cites W2072854874 @default.
- W4289202352 cites W2077557314 @default.
- W4289202352 cites W2082214470 @default.
- W4289202352 cites W2082483181 @default.
- W4289202352 cites W2089625895 @default.
- W4289202352 cites W2093388324 @default.
- W4289202352 cites W2094621241 @default.
- W4289202352 cites W2116896926 @default.
- W4289202352 cites W2117072114 @default.
- W4289202352 cites W2124631799 @default.
- W4289202352 cites W2127001268 @default.
- W4289202352 cites W2130607828 @default.
- W4289202352 cites W2136967721 @default.
- W4289202352 cites W2153000646 @default.
- W4289202352 cites W2164978656 @default.
- W4289202352 cites W2169974120 @default.
- W4289202352 cites W2170523243 @default.
- W4289202352 cites W2203567572 @default.
- W4289202352 cites W2256427311 @default.
- W4289202352 cites W2265497608 @default.
- W4289202352 cites W2289434161 @default.
- W4289202352 cites W2304040991 @default.
- W4289202352 cites W2317095610 @default.
- W4289202352 cites W2321365024 @default.
- W4289202352 cites W2323497364 @default.
- W4289202352 cites W2327797296 @default.
- W4289202352 cites W2505286042 @default.
- W4289202352 cites W2523305619 @default.
- W4289202352 cites W2549971631 @default.
- W4289202352 cites W2568171404 @default.
- W4289202352 cites W2591014544 @default.
- W4289202352 cites W2612810546 @default.
- W4289202352 cites W2741905622 @default.
- W4289202352 cites W2767724157 @default.
- W4289202352 cites W2793835583 @default.
- W4289202352 cites W2803629579 @default.
- W4289202352 cites W2804131187 @default.
- W4289202352 cites W2804301217 @default.
- W4289202352 cites W2887207364 @default.
- W4289202352 cites W2891697914 @default.
- W4289202352 cites W2895368736 @default.
- W4289202352 cites W2919108586 @default.
- W4289202352 cites W2921188989 @default.
- W4289202352 cites W2949951507 @default.
- W4289202352 cites W2967575151 @default.
- W4289202352 cites W2969639913 @default.
- W4289202352 cites W2984932295 @default.
- W4289202352 cites W3021610816 @default.
- W4289202352 cites W303483698 @default.
- W4289202352 cites W3112049152 @default.
- W4289202352 cites W3125601975 @default.
- W4289202352 cites W3132275434 @default.
- W4289202352 cites W3180198179 @default.
- W4289202352 cites W3193517130 @default.
- W4289202352 cites W3196805038 @default.
- W4289202352 cites W4205928742 @default.
- W4289202352 cites W4236746908 @default.
- W4289202352 cites W4300789682 @default.
- W4289202352 doi "https://doi.org/10.1002/slct.202201915" @default.
- W4289202352 hasPublicationYear "2022" @default.
- W4289202352 type Work @default.
- W4289202352 citedByCount "2" @default.
- W4289202352 countsByYear W42892023522023 @default.
- W4289202352 crossrefType "journal-article" @default.
- W4289202352 hasAuthorship W4289202352A5014025952 @default.
- W4289202352 hasAuthorship W4289202352A5023193536 @default.
- W4289202352 hasAuthorship W4289202352A5058895780 @default.
- W4289202352 hasAuthorship W4289202352A5084854319 @default.
- W4289202352 hasConcept C14430832 @default.
- W4289202352 hasConcept C159047783 @default.
- W4289202352 hasConcept C2780035454 @default.