FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289203934> ?p ?o ?g. }

• W4289203934 endingPage "954" @default.
• W4289203934 startingPage "954" @default.
• W4289203934 abstract "Pinocembrin is one of the well-known compounds in the group of flavonoids. The pharmacological activities of pinocembrin in association with wound-healing activities have been reported. However, its effects on the aspect of cellular interaction underlying growth and survival are still unidentified in human keratinocytes. Our previous study reported that Boesenbergia rotunda potently stimulated survival and proliferation of a human keratinocyte cell line (HaCaT). On the basis that pinocembrin is revealed to be one of the major constituents of this plant, we aimed to define the survival- and proliferation-enhancing effects of this compound at the cellular level. Results from the current study confirmed that pinocembrin induced an increase in HaCaT cell number. At the signaling perspective, we identified that pinocembrin significantly triggered ERK1/2 and Akt activation. The stimulating effects of pinocembrin were clearly inhibited by MEK and PI3K inhibitors authenticating that proliferation- and survival-promoting activities of pinocembrin were mainly acted on these two signaling cascades. Altogether, we successfully identified that pinocembrin functions to induce keratinocyte proliferation and survival, at least by provoking MAPK and PI3K pathways. Our study encourages the fact that pinocembrin is one of the interesting natural flavonoid compounds to be developed as a wound closure-promoting agent." @default.
• W4289203934 created "2022-08-01" @default.
• W4289203934 creator A5020933226 @default.
• W4289203934 creator A5025456798 @default.
• W4289203934 creator A5025830537 @default.
• W4289203934 creator A5067045912 @default.
• W4289203934 date "2022-07-31" @default.
• W4289203934 modified "2023-09-30" @default.
• W4289203934 title "Molecular Targets of Pinocembrin Underlying Its Regenerative Activities in Human Keratinocytes" @default.
• W4289203934 cites W1492468638 @default.
• W4289203934 cites W1966441345 @default.
• W4289203934 cites W1984658969 @default.
• W4289203934 cites W1985764146 @default.
• W4289203934 cites W1986308133 @default.
• W4289203934 cites W1991272056 @default.
• W4289203934 cites W2002476541 @default.
• W4289203934 cites W2006270737 @default.
• W4289203934 cites W2009026769 @default.
• W4289203934 cites W2013794249 @default.
• W4289203934 cites W2043513860 @default.
• W4289203934 cites W2045232408 @default.
• W4289203934 cites W2045365632 @default.
• W4289203934 cites W2051149325 @default.
• W4289203934 cites W2062635534 @default.
• W4289203934 cites W2064539618 @default.
• W4289203934 cites W2090568184 @default.
• W4289203934 cites W2110402724 @default.
• W4289203934 cites W2121158501 @default.
• W4289203934 cites W2127938351 @default.
• W4289203934 cites W2142191815 @default.
• W4289203934 cites W2150690655 @default.
• W4289203934 cites W2160926271 @default.
• W4289203934 cites W2292956350 @default.
• W4289203934 cites W2313226498 @default.
• W4289203934 cites W2395380593 @default.
• W4289203934 cites W2414994523 @default.
• W4289203934 cites W2481932906 @default.
• W4289203934 cites W2566399670 @default.
• W4289203934 cites W2574904481 @default.
• W4289203934 cites W2595058357 @default.
• W4289203934 cites W2730266027 @default.
• W4289203934 cites W2913798745 @default.
• W4289203934 cites W2922859673 @default.
• W4289203934 cites W3012380224 @default.
• W4289203934 cites W3044631602 @default.
• W4289203934 cites W3099913441 @default.
• W4289203934 cites W3122830429 @default.
• W4289203934 cites W3148302961 @default.
• W4289203934 cites W3180266117 @default.
• W4289203934 cites W3180434180 @default.
• W4289203934 cites W323560931 @default.
• W4289203934 cites W4280498381 @default.
• W4289203934 cites W92378175 @default.
• W4289203934 doi "https://doi.org/10.3390/ph15080954" @default.
• W4289203934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36015102" @default.
• W4289203934 hasPublicationYear "2022" @default.
• W4289203934 type Work @default.
• W4289203934 citedByCount "2" @default.
• W4289203934 countsByYear W42892039342023 @default.
• W4289203934 crossrefType "journal-article" @default.
• W4289203934 hasAuthorship W4289203934A5020933226 @default.
• W4289203934 hasAuthorship W4289203934A5025456798 @default.
• W4289203934 hasAuthorship W4289203934A5025830537 @default.
• W4289203934 hasAuthorship W4289203934A5067045912 @default.
• W4289203934 hasBestOaLocation W42892039341 @default.
• W4289203934 hasConcept C118995209 @default.
• W4289203934 hasConcept C185592680 @default.
• W4289203934 hasConcept C202751555 @default.
• W4289203934 hasConcept C2777074287 @default.
• W4289203934 hasConcept C2777702976 @default.
• W4289203934 hasConcept C2778004101 @default.
• W4289203934 hasConcept C2779054382 @default.
• W4289203934 hasConcept C55493867 @default.
• W4289203934 hasConcept C62112901 @default.
• W4289203934 hasConcept C86803240 @default.
• W4289203934 hasConcept C95444343 @default.
• W4289203934 hasConcept C98274493 @default.
• W4289203934 hasConceptScore W4289203934C118995209 @default.
• W4289203934 hasConceptScore W4289203934C185592680 @default.
• W4289203934 hasConceptScore W4289203934C202751555 @default.
• W4289203934 hasConceptScore W4289203934C2777074287 @default.
• W4289203934 hasConceptScore W4289203934C2777702976 @default.
• W4289203934 hasConceptScore W4289203934C2778004101 @default.
• W4289203934 hasConceptScore W4289203934C2779054382 @default.
• W4289203934 hasConceptScore W4289203934C55493867 @default.
• W4289203934 hasConceptScore W4289203934C62112901 @default.
• W4289203934 hasConceptScore W4289203934C86803240 @default.
• W4289203934 hasConceptScore W4289203934C95444343 @default.
• W4289203934 hasConceptScore W4289203934C98274493 @default.
• W4289203934 hasFunder F4320322817 @default.
• W4289203934 hasIssue "8" @default.
• W4289203934 hasLocation W42892039341 @default.
• W4289203934 hasLocation W42892039342 @default.
• W4289203934 hasLocation W42892039343 @default.
• W4289203934 hasOpenAccess W4289203934 @default.
• W4289203934 hasPrimaryLocation W42892039341 @default.
• W4289203934 hasRelatedWork W108184611 @default.
• W4289203934 hasRelatedWork W1782508467 @default.

• next