FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289204525> ?p ?o ?g. }

• W4289204525 endingPage "1594" @default.
• W4289204525 startingPage "1594" @default.
• W4289204525 abstract "The widespread use of added sugars or non-nutritive sweeteners in processed foods is a challenge for addressing the therapeutics of obesity and diabetes. Both types of sweeteners generate health problems, and both are being blamed for multiple complications associated with these prevalent diseases. As an example, fructose is proven to contribute to obesity and liver steatosis, while non-nutritive sweeteners generate gut dysbiosis that complicates the metabolic control exerted by the liver. The present work explores an alternative approach for sweetening through the use of a simple carob-pod-derived syrup. This sweetener consists of a balanced mixture of fructose (47%) and glucose (45%), as sweetening sugars, and a functional natural ingredient (D-Pinitol) at a concentration (3%) capable of producing active metabolic effects. The administration of this syrup to healthy volunteers (50 g of total carbohydrates) resulted in less persistent glucose excursions, a lower insulin response to the hyperglycemia produced by its ingestion, and an enhanced glucagon/insulin ratio, compared to that observed after the ingestion of 50 g of glucose. Daily administration of the syrup to Wistar rats for 10 days lowered fat depots in the liver, reduced liver glycogen, promoted fat oxidation, and was devoid of toxic effects. In addition, this repeated administration of the syrup improved glucose handling after a glucose (2 g/kg) load. Overall, this alternative functional sweetener retains the natural palatability of a glucose/fructose syrup while displaying beneficial metabolic effects that might serve to protect against the progression towards complicated obesity, especially the development of liver steatosis." @default.
• W4289204525 created "2022-08-01" @default.
• W4289204525 creator A5006603148 @default.
• W4289204525 creator A5007530354 @default.
• W4289204525 creator A5013915946 @default.
• W4289204525 creator A5015422381 @default.
• W4289204525 creator A5020177811 @default.
• W4289204525 creator A5027017283 @default.
• W4289204525 creator A5035349200 @default.
• W4289204525 creator A5039101706 @default.
• W4289204525 creator A5053086632 @default.
• W4289204525 creator A5062877036 @default.
• W4289204525 creator A5071247507 @default.
• W4289204525 creator A5073592431 @default.
• W4289204525 creator A5086353415 @default.
• W4289204525 date "2022-07-30" @default.
• W4289204525 modified "2023-10-16" @default.
• W4289204525 title "Endocrine and Metabolic Impact of Oral Ingestion of a Carob-Pod-Derived Natural-Syrup-Containing D-Pinitol: Potential Use as a Novel Sweetener in Diabetes" @default.
• W4289204525 cites W1492780847 @default.
• W4289204525 cites W2012168904 @default.
• W4289204525 cites W2032321233 @default.
• W4289204525 cites W2040754875 @default.
• W4289204525 cites W2049069390 @default.
• W4289204525 cites W2081517645 @default.
• W4289204525 cites W2084630716 @default.
• W4289204525 cites W2109116726 @default.
• W4289204525 cites W2147496400 @default.
• W4289204525 cites W2152311269 @default.
• W4289204525 cites W2153696332 @default.
• W4289204525 cites W2160234571 @default.
• W4289204525 cites W2164366280 @default.
• W4289204525 cites W2165822611 @default.
• W4289204525 cites W2300552860 @default.
• W4289204525 cites W2404954745 @default.
• W4289204525 cites W2572657948 @default.
• W4289204525 cites W2607031541 @default.
• W4289204525 cites W2611502608 @default.
• W4289204525 cites W2623923045 @default.
• W4289204525 cites W2625046252 @default.
• W4289204525 cites W2734494266 @default.
• W4289204525 cites W2742403391 @default.
• W4289204525 cites W2751789497 @default.
• W4289204525 cites W2800677448 @default.
• W4289204525 cites W2907742136 @default.
• W4289204525 cites W2914359073 @default.
• W4289204525 cites W2930013090 @default.
• W4289204525 cites W2940783197 @default.
• W4289204525 cites W2955219150 @default.
• W4289204525 cites W2977354602 @default.
• W4289204525 cites W3016832984 @default.
• W4289204525 cites W3022593374 @default.
• W4289204525 cites W3031610266 @default.
• W4289204525 cites W3073572811 @default.
• W4289204525 cites W3118800583 @default.
• W4289204525 cites W3128522617 @default.
• W4289204525 cites W3133207484 @default.
• W4289204525 cites W3155768182 @default.
• W4289204525 cites W3171607665 @default.
• W4289204525 cites W3175778934 @default.
• W4289204525 cites W3202816718 @default.
• W4289204525 cites W4224547505 @default.
• W4289204525 cites W4281632180 @default.
• W4289204525 cites W4283701786 @default.
• W4289204525 cites W4296816736 @default.
• W4289204525 cites W569773320 @default.
• W4289204525 doi "https://doi.org/10.3390/pharmaceutics14081594" @default.
• W4289204525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36015220" @default.
• W4289204525 hasPublicationYear "2022" @default.
• W4289204525 type Work @default.
• W4289204525 citedByCount "1" @default.
• W4289204525 countsByYear W42892045252023 @default.
• W4289204525 crossrefType "journal-article" @default.
• W4289204525 hasAuthorship W4289204525A5006603148 @default.
• W4289204525 hasAuthorship W4289204525A5007530354 @default.
• W4289204525 hasAuthorship W4289204525A5013915946 @default.
• W4289204525 hasAuthorship W4289204525A5015422381 @default.
• W4289204525 hasAuthorship W4289204525A5020177811 @default.
• W4289204525 hasAuthorship W4289204525A5027017283 @default.
• W4289204525 hasAuthorship W4289204525A5035349200 @default.
• W4289204525 hasAuthorship W4289204525A5039101706 @default.
• W4289204525 hasAuthorship W4289204525A5053086632 @default.
• W4289204525 hasAuthorship W4289204525A5062877036 @default.
• W4289204525 hasAuthorship W4289204525A5071247507 @default.
• W4289204525 hasAuthorship W4289204525A5073592431 @default.
• W4289204525 hasAuthorship W4289204525A5086353415 @default.
• W4289204525 hasBestOaLocation W42892045251 @default.
• W4289204525 hasConcept C134018914 @default.
• W4289204525 hasConcept C172873279 @default.
• W4289204525 hasConcept C185592680 @default.
• W4289204525 hasConcept C193230392 @default.
• W4289204525 hasConcept C2776970464 @default.
• W4289204525 hasConcept C2777499176 @default.
• W4289204525 hasConcept C2778062710 @default.
• W4289204525 hasConcept C2778597767 @default.
• W4289204525 hasConcept C2779018100 @default.
• W4289204525 hasConcept C2780589914 @default.
• W4289204525 hasConcept C31903555 @default.
• W4289204525 hasConcept C71924100 @default.

• next