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- W4289205736 endingPage "3115" @default.
- W4289205736 startingPage "3115" @default.
- W4289205736 abstract "Mitochondrial function, including oxidative phosphorylation (OXPHOS), mitochondrial biogenesis, and mitochondria dynamics, are essential for the maintenance of renal health. Through modulation of mitochondrial function, the kidneys are able to sustain or recover acute kidney injury (AKI), chronic kidney disease (CKD), nephrotoxicity, nephropathy, and ischemia perfusion. Therapeutic improvement in mitochondrial function in the kidneys is related to the regulation of adenosine triphosphate (ATP) production, free radicals scavenging, decline in apoptosis, and inflammation. Dietary antioxidants, notably polyphenols present in fruits, vegetables, and plants, have attracted attention as effective dietary and pharmacological interventions. Considerable evidence shows that polyphenols protect against mitochondrial damage in different experimental models of kidney disease. Mechanistically, polyphenols regulate the mitochondrial redox status, apoptosis, and multiple intercellular signaling pathways. Therefore, this review attempts to focus on the role of polyphenols in the prevention or treatment of kidney disease and explore the molecular mechanisms associated with their pharmacological activity." @default.
- W4289205736 created "2022-08-01" @default.
- W4289205736 creator A5012561111 @default.
- W4289205736 creator A5045391880 @default.
- W4289205736 creator A5067633981 @default.
- W4289205736 date "2022-07-29" @default.
- W4289205736 modified "2023-09-26" @default.
- W4289205736 title "The Effect of Polyphenols on Kidney Disease: Targeting Mitochondria" @default.
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