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• W4289222739 abstract "Microscopic colitis is an inflammatory bowel disease divided into two subtypes: collagenous colitis and lymphocytic colitis. With an increasing incidence of microscopic colitis exceeding those of ulcerative and Crohn's disease among elderly people in some countries, microscopic colitis is a debilitating life experience. Therefore, physicians should be familiar with its clinical features and management strategies because the disease deserves the same attention as the classical inflammatory bowel diseases. Here, state-of-the-art knowledge of microscopic colitis is provided from a global perspective with reference to etiopathology and how to establish the diagnosis with the overall aim to create awareness and improve rational management in clinical practice. The immune system and a dysregulated immune response seem to play a key role combined with risk factors (e.g. cigarette smoking) in genetically predisposed individuals. The symptoms are characterized by recurrent or chronic nonbloody, watery diarrhea, urgency, weight loss, and a female preponderance. As biomarkers are absent, the diagnosis relies on colonoscopy with a histological assessment of biopsy specimens from all parts of the colon. Although the disease is not associated with a risk of colorectal cancer, a recent nationwide, population-based cohort study found an increased risk of lymphoma and lung cancer. Budesonide is the first-line therapy for management, whereas immunomodulatory drugs (including biologics) and drugs with antidiarrheal properties may be indicated in those failing, dependent, or intolerant to budesonide. In microscopic colitis induced by checkpoint inhibitors, a drug class used increasingly for a wide range of malignancies, a more aggressive therapeutic approach with biologics introduced early seems reasonable. However, particular attention needs to be drawn to the existence of incomplete forms of microscopic colitis with the risk of being overlooked in routine clinical settings." @default.
• W4289222739 created "2022-08-01" @default.
• W4289222739 creator A5008463240 @default.
• W4289222739 creator A5008574018 @default.
• W4289222739 creator A5011906232 @default.
• W4289222739 creator A5016245381 @default.
• W4289222739 date "2022-08-01" @default.
• W4289222739 modified "2023-09-30" @default.
• W4289222739 title "Microscopic colitis: Etiopathology, diagnosis, and rational management" @default.
• W4289222739 cites W1591931848 @default.
• W4289222739 cites W1639804796 @default.
• W4289222739 cites W190120881 @default.
• W4289222739 cites W1934312222 @default.
• W4289222739 cites W1970670991 @default.
• W4289222739 cites W1973719881 @default.
• W4289222739 cites W1982872763 @default.
• W4289222739 cites W1991897564 @default.
• W4289222739 cites W2000882482 @default.
• W4289222739 cites W2021015942 @default.
• W4289222739 cites W2029963594 @default.
• W4289222739 cites W2038499465 @default.
• W4289222739 cites W2041285295 @default.
• W4289222739 cites W2045679496 @default.
• W4289222739 cites W2052194882 @default.
• W4289222739 cites W2054708407 @default.
• W4289222739 cites W2054863312 @default.
• W4289222739 cites W2058945014 @default.
• W4289222739 cites W2060038066 @default.
• W4289222739 cites W2061678430 @default.
• W4289222739 cites W2075468337 @default.
• W4289222739 cites W2077248729 @default.
• W4289222739 cites W2082704080 @default.
• W4289222739 cites W2091378987 @default.
• W4289222739 cites W2093573853 @default.
• W4289222739 cites W2104269632 @default.
• W4289222739 cites W2104634857 @default.
• W4289222739 cites W2111058788 @default.
• W4289222739 cites W2115882991 @default.
• W4289222739 cites W2122678604 @default.
• W4289222739 cites W2123392033 @default.
• W4289222739 cites W2130728705 @default.
• W4289222739 cites W2134304452 @default.
• W4289222739 cites W2134627757 @default.
• W4289222739 cites W2140714252 @default.
• W4289222739 cites W2145611254 @default.
• W4289222739 cites W2146025362 @default.
• W4289222739 cites W2149148307 @default.
• W4289222739 cites W2155704570 @default.
• W4289222739 cites W2156081361 @default.
• W4289222739 cites W2179522331 @default.
• W4289222739 cites W2205185074 @default.
• W4289222739 cites W2221460625 @default.
• W4289222739 cites W2294580066 @default.
• W4289222739 cites W2305561114 @default.
• W4289222739 cites W2418156720 @default.
• W4289222739 cites W2491800252 @default.
• W4289222739 cites W2507141640 @default.
• W4289222739 cites W2559448577 @default.
• W4289222739 cites W2579646379 @default.
• W4289222739 cites W2581198696 @default.
• W4289222739 cites W2590191133 @default.
• W4289222739 cites W2594109702 @default.
• W4289222739 cites W2610821222 @default.
• W4289222739 cites W2613935821 @default.
• W4289222739 cites W2744951374 @default.
• W4289222739 cites W2794476791 @default.
• W4289222739 cites W2807512477 @default.
• W4289222739 cites W2884462821 @default.
• W4289222739 cites W2884943040 @default.
• W4289222739 cites W2888968319 @default.
• W4289222739 cites W2889010718 @default.
• W4289222739 cites W2889907620 @default.
• W4289222739 cites W2891703361 @default.
• W4289222739 cites W2896391066 @default.
• W4289222739 cites W2903072327 @default.
• W4289222739 cites W2911281331 @default.
• W4289222739 cites W2913678471 @default.
• W4289222739 cites W2922476638 @default.
• W4289222739 cites W2941102343 @default.
• W4289222739 cites W2945600676 @default.
• W4289222739 cites W2949582656 @default.
• W4289222739 cites W2955892067 @default.
• W4289222739 cites W2963214932 @default.
• W4289222739 cites W2966100508 @default.
• W4289222739 cites W2969489093 @default.
• W4289222739 cites W2969630163 @default.
• W4289222739 cites W2970318044 @default.
• W4289222739 cites W2971888139 @default.
• W4289222739 cites W2979442781 @default.
• W4289222739 cites W2987833617 @default.
• W4289222739 cites W2999636890 @default.
• W4289222739 cites W2999721465 @default.
• W4289222739 cites W3005441056 @default.
• W4289222739 cites W3005733169 @default.
• W4289222739 cites W3008496815 @default.
• W4289222739 cites W3021549706 @default.
• W4289222739 cites W3022166459 @default.
• W4289222739 cites W3027249011 @default.
• W4289222739 cites W3034104472 @default.
• W4289222739 cites W3041834813 @default.

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