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- W4289261040 abstract "Abstract Purpose To describe US drug shortages affecting medications on the 2019 World Health Organization (WHO) Model List of Essential Medicines for Children (EMLc). Methods Drug shortage data from January 2014 to December 2019 were obtained from the University of Utah Drug Information Service. Shortage data for drugs on the EMLc were analyzed for the type of drug, American Hospital Formulary Service category, reason for the shortage, duration of the shortage, marketing status (generic vs brand name), and whether the agent was a single- or multisource drug. Results From 2014 to 2019, a total of 209 drug shortages impacted medications on the EMLc, of which 77 (36.8%) remained unresolved by 2019. Of all active shortages, 13 (6.2%) began before 2014. Resolved shortages had a median duration of 5.9 months (interquartile range [IQR], 3.6-13.2 months) while active shortages had a median duration of 18.3 months (IQR, 10.9-33.5 months; P ≤ 0.0001). The therapeutic categories most impacted by drug shortages were anti-infective agents (27.3%), central nervous system agents (12.9%), and antineoplastic agents (11.0%). The reason for the shortage was not reported in 46.4% of cases. When a reason was provided, the most common reason was manufacturing problems (29.2%) followed by supply/demand mismatch (15.8%). Conclusion US drug shortages affected many medications on the WHO EMLc. Future studies should examine the global shortage climate and implications for patient care." @default.
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- W4289261040 date "2022-08-01" @default.
- W4289261040 modified "2023-10-02" @default.
- W4289261040 title "US drug shortages compared to the World Health Organization’s Model List of Essential Medicines for Children: A cross-sectional study" @default.
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- W4289261040 doi "https://doi.org/10.1093/ajhp/zxac210" @default.
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