Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289261572> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4289261572 abstract "Abstract Background: Metastasis is a major factor associated with high recurrence and mortality in hepatocellular carcinoma patients while the underlying mechanism of metastasis remains elusive. In our study, PLOD2 was shown to be involved in the process of metastasis in HCC. Methods: TCGA database and HCC tissue microarrays were used to evaluate the expression of genes. In vitro migration, invasion, in vivo subcutaneous tumor model and in vivo lung metastasis assays were used to determine the role of PLOD2 in tumor growth and metastasis in HCC. RNA sequencing and gene set enrichment analysis were performed to uncover the downstream factor of PLOD2 in HCC cells. A luciferase reporter assay was performed to evaluate the interaction between PLOD2 and IRF5. Results: The expression of PLOD2 in HCC tissues was higher than that in adjacent tissues, and increased PLOD2 expression was often found in advanced tumors and was correlated with poor prognosis in HCC patients. In vitro experiments, knockdown of PLOD2 reduced the migration and invasion of human HCC cells. Loss of PLOD2 suppressed human HCC growth and metastasis in a subcutaneous tumor model and a lung metastasis model. BIRC3 was proven to be the downstream factor of PLOD2 in human HCC cells. In addition, PLOD2 was transcriptionally regulated by IRF5 in HCC cells. Conclusion: High expression of PLOD2 was regulated by IRF5, which was correlated with the poor survival of HCC patients. PLOD2 enhanced HCC metastasis via BIRC3, suggesting that PLOD2 might be a valuable prognostic biomarker for HCC treatment." @default.
- W4289261572 created "2022-08-01" @default.
- W4289261572 creator A5006543483 @default.
- W4289261572 creator A5023111713 @default.
- W4289261572 creator A5024882473 @default.
- W4289261572 creator A5029212298 @default.
- W4289261572 creator A5039574585 @default.
- W4289261572 creator A5046183867 @default.
- W4289261572 creator A5051363890 @default.
- W4289261572 creator A5056517236 @default.
- W4289261572 creator A5067693027 @default.
- W4289261572 creator A5067972696 @default.
- W4289261572 creator A5076320945 @default.
- W4289261572 creator A5083907678 @default.
- W4289261572 date "2022-08-01" @default.
- W4289261572 modified "2023-09-28" @default.
- W4289261572 title "Dysregulation of PLOD2 promotes tumor metastasis and invasion in hepatocellular carcinoma" @default.
- W4289261572 doi "https://doi.org/10.21203/rs.3.rs-1858650/v1" @default.
- W4289261572 hasPublicationYear "2022" @default.
- W4289261572 type Work @default.
- W4289261572 citedByCount "0" @default.
- W4289261572 crossrefType "posted-content" @default.
- W4289261572 hasAuthorship W4289261572A5006543483 @default.
- W4289261572 hasAuthorship W4289261572A5023111713 @default.
- W4289261572 hasAuthorship W4289261572A5024882473 @default.
- W4289261572 hasAuthorship W4289261572A5029212298 @default.
- W4289261572 hasAuthorship W4289261572A5039574585 @default.
- W4289261572 hasAuthorship W4289261572A5046183867 @default.
- W4289261572 hasAuthorship W4289261572A5051363890 @default.
- W4289261572 hasAuthorship W4289261572A5056517236 @default.
- W4289261572 hasAuthorship W4289261572A5067693027 @default.
- W4289261572 hasAuthorship W4289261572A5067972696 @default.
- W4289261572 hasAuthorship W4289261572A5076320945 @default.
- W4289261572 hasAuthorship W4289261572A5083907678 @default.
- W4289261572 hasBestOaLocation W42892615721 @default.
- W4289261572 hasConcept C121608353 @default.
- W4289261572 hasConcept C126322002 @default.
- W4289261572 hasConcept C137738243 @default.
- W4289261572 hasConcept C143998085 @default.
- W4289261572 hasConcept C1491633281 @default.
- W4289261572 hasConcept C173396325 @default.
- W4289261572 hasConcept C2778019345 @default.
- W4289261572 hasConcept C2779013556 @default.
- W4289261572 hasConcept C502942594 @default.
- W4289261572 hasConcept C54355233 @default.
- W4289261572 hasConcept C71924100 @default.
- W4289261572 hasConcept C81885089 @default.
- W4289261572 hasConcept C86803240 @default.
- W4289261572 hasConceptScore W4289261572C121608353 @default.
- W4289261572 hasConceptScore W4289261572C126322002 @default.
- W4289261572 hasConceptScore W4289261572C137738243 @default.
- W4289261572 hasConceptScore W4289261572C143998085 @default.
- W4289261572 hasConceptScore W4289261572C1491633281 @default.
- W4289261572 hasConceptScore W4289261572C173396325 @default.
- W4289261572 hasConceptScore W4289261572C2778019345 @default.
- W4289261572 hasConceptScore W4289261572C2779013556 @default.
- W4289261572 hasConceptScore W4289261572C502942594 @default.
- W4289261572 hasConceptScore W4289261572C54355233 @default.
- W4289261572 hasConceptScore W4289261572C71924100 @default.
- W4289261572 hasConceptScore W4289261572C81885089 @default.
- W4289261572 hasConceptScore W4289261572C86803240 @default.
- W4289261572 hasLocation W42892615721 @default.
- W4289261572 hasOpenAccess W4289261572 @default.
- W4289261572 hasPrimaryLocation W42892615721 @default.
- W4289261572 hasRelatedWork W2002597275 @default.
- W4289261572 hasRelatedWork W2048776092 @default.
- W4289261572 hasRelatedWork W2105309670 @default.
- W4289261572 hasRelatedWork W2119078898 @default.
- W4289261572 hasRelatedWork W219817571 @default.
- W4289261572 hasRelatedWork W2342028394 @default.
- W4289261572 hasRelatedWork W3001922991 @default.
- W4289261572 hasRelatedWork W3005333056 @default.
- W4289261572 hasRelatedWork W3173207637 @default.
- W4289261572 hasRelatedWork W4292080754 @default.
- W4289261572 isParatext "false" @default.
- W4289261572 isRetracted "false" @default.
- W4289261572 workType "article" @default.