Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289261775> ?p ?o ?g. }
- W4289261775 abstract "The phytohormone auxin, indole-3-acetic acid (IAA), plays a prominent role in plant development. Auxin homeostasis is coordinately regulated by auxin synthesis, transport, and inactivation; however, the physiological contribution of auxin inactivation to auxin homeostasis has not been determined. The GH3 IAA-amino acid conjugating enzymes play a central role in auxin inactivation. Chemical inhibition of GH3 proteins in planta is challenging because the inhibition of these enzymes leads to IAA overaccumulation that rapidly induces GH3 expression. Here, we report the characterization of a potent GH3 inhibitor, kakeimide, that selectively targets IAA-conjugating GH3 proteins. Chemical knockdown of the auxin inactivation pathway demonstrates that auxin turnover is very rapid (about 10 min) and indicates that both auxin biosynthesis and inactivation dynamically regulate auxin homeostasis." @default.
- W4289261775 created "2022-08-01" @default.
- W4289261775 creator A5003137941 @default.
- W4289261775 creator A5016227945 @default.
- W4289261775 creator A5018621706 @default.
- W4289261775 creator A5024547909 @default.
- W4289261775 creator A5033976569 @default.
- W4289261775 creator A5041627667 @default.
- W4289261775 creator A5061088407 @default.
- W4289261775 creator A5065692230 @default.
- W4289261775 creator A5067870042 @default.
- W4289261775 creator A5076554782 @default.
- W4289261775 creator A5090288638 @default.
- W4289261775 date "2022-08-01" @default.
- W4289261775 modified "2023-10-05" @default.
- W4289261775 title "Chemical inhibition of the auxin inactivation pathway uncovers the roles of metabolic turnover in auxin homeostasis" @default.
- W4289261775 cites W1963482273 @default.
- W4289261775 cites W1971294085 @default.
- W4289261775 cites W1972444108 @default.
- W4289261775 cites W2005975510 @default.
- W4289261775 cites W2008315771 @default.
- W4289261775 cites W2014207396 @default.
- W4289261775 cites W2019840081 @default.
- W4289261775 cites W2031530658 @default.
- W4289261775 cites W2056918727 @default.
- W4289261775 cites W2079091936 @default.
- W4289261775 cites W2079353588 @default.
- W4289261775 cites W2086654822 @default.
- W4289261775 cites W2108341815 @default.
- W4289261775 cites W2109354542 @default.
- W4289261775 cites W2110591857 @default.
- W4289261775 cites W2112853735 @default.
- W4289261775 cites W2119686296 @default.
- W4289261775 cites W2120442248 @default.
- W4289261775 cites W2123131099 @default.
- W4289261775 cites W2136136435 @default.
- W4289261775 cites W2145955764 @default.
- W4289261775 cites W2146687182 @default.
- W4289261775 cites W2150431323 @default.
- W4289261775 cites W2150851093 @default.
- W4289261775 cites W2150943030 @default.
- W4289261775 cites W2158957969 @default.
- W4289261775 cites W2164018166 @default.
- W4289261775 cites W2164185725 @default.
- W4289261775 cites W2166878800 @default.
- W4289261775 cites W2169918138 @default.
- W4289261775 cites W2171914198 @default.
- W4289261775 cites W2177206323 @default.
- W4289261775 cites W2306708527 @default.
- W4289261775 cites W2522159157 @default.
- W4289261775 cites W2522670482 @default.
- W4289261775 cites W2549415262 @default.
- W4289261775 cites W2549608458 @default.
- W4289261775 cites W2559798636 @default.
- W4289261775 cites W2607429891 @default.
- W4289261775 cites W2755216278 @default.
- W4289261775 cites W2765628147 @default.
- W4289261775 cites W2769201995 @default.
- W4289261775 cites W2787605273 @default.
- W4289261775 cites W2808165554 @default.
- W4289261775 cites W2931173915 @default.
- W4289261775 cites W2977812363 @default.
- W4289261775 cites W3026138516 @default.
- W4289261775 cites W3082438992 @default.
- W4289261775 cites W3107127614 @default.
- W4289261775 cites W3119483631 @default.
- W4289261775 cites W3120635012 @default.
- W4289261775 cites W3151782171 @default.
- W4289261775 cites W3163233154 @default.
- W4289261775 cites W3165603545 @default.
- W4289261775 cites W3215915240 @default.
- W4289261775 cites W3216752034 @default.
- W4289261775 cites W4212889928 @default.
- W4289261775 cites W4220762243 @default.
- W4289261775 doi "https://doi.org/10.1073/pnas.2206869119" @default.
- W4289261775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35914172" @default.
- W4289261775 hasPublicationYear "2022" @default.
- W4289261775 type Work @default.
- W4289261775 citedByCount "11" @default.
- W4289261775 countsByYear W42892617752022 @default.
- W4289261775 countsByYear W42892617752023 @default.
- W4289261775 crossrefType "journal-article" @default.
- W4289261775 hasAuthorship W4289261775A5003137941 @default.
- W4289261775 hasAuthorship W4289261775A5016227945 @default.
- W4289261775 hasAuthorship W4289261775A5018621706 @default.
- W4289261775 hasAuthorship W4289261775A5024547909 @default.
- W4289261775 hasAuthorship W4289261775A5033976569 @default.
- W4289261775 hasAuthorship W4289261775A5041627667 @default.
- W4289261775 hasAuthorship W4289261775A5061088407 @default.
- W4289261775 hasAuthorship W4289261775A5065692230 @default.
- W4289261775 hasAuthorship W4289261775A5067870042 @default.
- W4289261775 hasAuthorship W4289261775A5076554782 @default.
- W4289261775 hasAuthorship W4289261775A5090288638 @default.
- W4289261775 hasBestOaLocation W42892617751 @default.
- W4289261775 hasConcept C104317684 @default.
- W4289261775 hasConcept C185592680 @default.
- W4289261775 hasConcept C207778908 @default.
- W4289261775 hasConcept C2778707554 @default.
- W4289261775 hasConcept C55493867 @default.
- W4289261775 hasConcept C63645605 @default.