FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289261854> ?p ?o ?g. }

• W4289261854 abstract "Sputnik-V (Gam-COVID-Vac) is a heterologous, recombinant adenoviral (rAdv) vector-based, COVID-19 vaccine now used in > 70 countries. Yet there is a shortage of data on this vaccine's performance in diverse populations. Here, we performed a prospective cohort study to assess the reactogenicity and immunologic outcomes of Sputnik-V vaccination in Kazakhstan. COVID-19-free participants (n = 82 at baseline) were followed at day 21 after Sputnik-V dose 1 (rAd5) and dose 2 (rAd26). Self-reported local and systemic adverse events were captured using questionnaires. Blood and nasopharyngeal swabs were collected to perform SARS-CoV-2 diagnostic and immunologic assays. We observed that most of the reported adverse events were mild-to-moderate injection site or systemic reactions, no severe or potentially life-threatening conditions were reported, and dose 1 appeared to be more reactogenic than dose 2. The seroconversion rate was 97% post-dose 1, remaining the same post-dose 2. The proportion of participants with detectable virus neutralization was 83% post-dose 1, increasing to 98% post-dose 2, with the largest relative increase observed in participants without prior COVID-19 exposure. Dose 1 boosted nasal S-IgG and S-IgA, while the boosting effect of dose 2 on mucosal S-IgG, but not S-IgA, was only observed in subjects without prior COVID-19. Systemically, vaccination reduced serum levels of growth regulated oncogene (GRO), which correlated with an elevation in blood platelet count. Overall, Sputnik-V dose 1 elicited both blood and mucosal SARS-CoV-2 immunity, while the immune boosting effect of dose 2 was minimal. Thus, adjustments to the current vaccine dosing regimen are necessary to optimize immunization efficacy and cost-effectiveness. While Sputnik-V reactogenicity is similar to that of other COVID-19 vaccines, the induced alterations to the GRO/platelet axis warrant investigation of the vaccine's effects on systemic immunology." @default.
• W4289261854 created "2022-08-01" @default.
• W4289261854 creator A5004048006 @default.
• W4289261854 creator A5006380346 @default.
• W4289261854 creator A5007198575 @default.
• W4289261854 creator A5011451693 @default.
• W4289261854 creator A5012361177 @default.
• W4289261854 creator A5025618316 @default.
• W4289261854 creator A5027931480 @default.
• W4289261854 creator A5051071062 @default.
• W4289261854 creator A5066625736 @default.
• W4289261854 creator A5078310893 @default.
• W4289261854 creator A5086039635 @default.
• W4289261854 date "2022-08-01" @default.
• W4289261854 modified "2023-10-14" @default.
• W4289261854 title "Sputnik-V reactogenicity and immunogenicity in the blood and mucosa: a prospective cohort study" @default.
• W4289261854 cites W1953168623 @default.
• W4289261854 cites W2025369903 @default.
• W4289261854 cites W2051659042 @default.
• W4289261854 cites W2064468702 @default.
• W4289261854 cites W2616719177 @default.
• W4289261854 cites W3014721277 @default.
• W4289261854 cites W3027576812 @default.
• W4289261854 cites W3028108966 @default.
• W4289261854 cites W3039328844 @default.
• W4289261854 cites W3041438918 @default.
• W4289261854 cites W3083750089 @default.
• W4289261854 cites W3090832537 @default.
• W4289261854 cites W3127329393 @default.
• W4289261854 cites W3128620152 @default.
• W4289261854 cites W3128851946 @default.
• W4289261854 cites W3154722887 @default.
• W4289261854 cites W3154979745 @default.
• W4289261854 cites W3158373340 @default.
• W4289261854 cites W3161318679 @default.
• W4289261854 cites W3162259371 @default.
• W4289261854 cites W3164902528 @default.
• W4289261854 cites W3169680644 @default.
• W4289261854 cites W3175112548 @default.
• W4289261854 cites W3180389052 @default.
• W4289261854 cites W3181043166 @default.
• W4289261854 cites W3186153681 @default.
• W4289261854 cites W3192558869 @default.
• W4289261854 cites W3194789395 @default.
• W4289261854 cites W3205156908 @default.
• W4289261854 cites W3206318896 @default.
• W4289261854 cites W3207514894 @default.
• W4289261854 cites W3209290058 @default.
• W4289261854 cites W3214214368 @default.
• W4289261854 cites W3216544576 @default.
• W4289261854 cites W3216944372 @default.
• W4289261854 cites W3217514210 @default.
• W4289261854 cites W4200053053 @default.
• W4289261854 cites W4200214306 @default.
• W4289261854 cites W4200262916 @default.
• W4289261854 cites W4210641662 @default.
• W4289261854 cites W4210957428 @default.
• W4289261854 cites W4221110051 @default.
• W4289261854 cites W4224319009 @default.
• W4289261854 cites W4225695315 @default.
• W4289261854 cites W4248726376 @default.
• W4289261854 cites W4281260975 @default.
• W4289261854 cites W4283073217 @default.
• W4289261854 cites W4283207872 @default.
• W4289261854 cites W4288068195 @default.
• W4289261854 doi "https://doi.org/10.1038/s41598-022-17514-3" @default.
• W4289261854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35915123" @default.
• W4289261854 hasPublicationYear "2022" @default.
• W4289261854 type Work @default.
• W4289261854 citedByCount "7" @default.
• W4289261854 countsByYear W42892618542022 @default.
• W4289261854 countsByYear W42892618542023 @default.
• W4289261854 crossrefType "journal-article" @default.
• W4289261854 hasAuthorship W4289261854A5004048006 @default.
• W4289261854 hasAuthorship W4289261854A5006380346 @default.
• W4289261854 hasAuthorship W4289261854A5007198575 @default.
• W4289261854 hasAuthorship W4289261854A5011451693 @default.
• W4289261854 hasAuthorship W4289261854A5012361177 @default.
• W4289261854 hasAuthorship W4289261854A5025618316 @default.
• W4289261854 hasAuthorship W4289261854A5027931480 @default.
• W4289261854 hasAuthorship W4289261854A5051071062 @default.
• W4289261854 hasAuthorship W4289261854A5066625736 @default.
• W4289261854 hasAuthorship W4289261854A5078310893 @default.
• W4289261854 hasAuthorship W4289261854A5086039635 @default.
• W4289261854 hasBestOaLocation W42892618541 @default.
• W4289261854 hasConcept C126322002 @default.
• W4289261854 hasConcept C159654299 @default.
• W4289261854 hasConcept C188816634 @default.
• W4289261854 hasConcept C197934379 @default.
• W4289261854 hasConcept C203014093 @default.
• W4289261854 hasConcept C22070199 @default.
• W4289261854 hasConcept C2777451964 @default.
• W4289261854 hasConcept C2777704310 @default.
• W4289261854 hasConcept C2780868878 @default.
• W4289261854 hasConcept C71924100 @default.
• W4289261854 hasConcept C72563966 @default.
• W4289261854 hasConcept C8891405 @default.
• W4289261854 hasConceptScore W4289261854C126322002 @default.
• W4289261854 hasConceptScore W4289261854C159654299 @default.
• W4289261854 hasConceptScore W4289261854C188816634 @default.

• next