Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289333478> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4289333478 abstract "The sodium dependent SLC13 family transporters comprise of the five genes SLC13A1, SLC13A2 (NaDC1), SLC13A3 (NaDC3), SLC13A4 and SLC13A5 (NaCT). Among them the three NaDC1, NaDC3 and NaCT are sodium dependent transporters such as di-carboxylates (succinate, malate, α-ketoglutarate) and tricarboxylates (citrate). The mouse and the human NaCT structures have still not been crystallized, the information to the structures is taken from the related bacterial transporter of VcINDY. Citrate in the cytosol works as precursor for the fatty acid synthesis, cholesterol, and low-density lipoproteins. The excess citrate from the matrix is translocated to the cytosol for fatty acid synthesis through these receptors and thus controls the energy balance by downregulating the glycolysis, tricarboxylic acid (TCA), and fatty acid breakdown. These transporters play an important role in regulating various metabolic diseases including cancer, diabetes, obesity, fatty liver diseases and CNS disorders. These di and tricarboxylate transporters are emerging as new targets for metabolic disorders such as obesity and diabetes. The mutation in the function of the NaCT causes several neurological diseases including neonatal epilepsy and impaired brain development whereas mutation of the citrate present in the liver may provide positive effect. Therefore, continued efforts from the earlier work on citrate transporter are required for the development of citrate inhibitors. In this review the structure, function, and regulation of the NaCT receptors are discussed. The review also highlights citrate role in diagnosing diseases such as cancer, diabetes, fatty liver, and diabetes. The therapeutic perspective of synthetic inhibitors against NaCT receptors are succinctly summarized." @default.
- W4289333478 created "2022-08-02" @default.
- W4289333478 creator A5007941660 @default.
- W4289333478 creator A5030817137 @default.
- W4289333478 creator A5037413888 @default.
- W4289333478 creator A5059698457 @default.
- W4289333478 creator A5066089435 @default.
- W4289333478 creator A5067542439 @default.
- W4289333478 date "2022-08-01" @default.
- W4289333478 modified "2023-09-29" @default.
- W4289333478 title "Role of Sodium dependent SLC13 transporter and its inhibitors in various metabolic disorders" @default.
- W4289333478 doi "https://doi.org/10.22541/au.165934649.91075499/v1" @default.
- W4289333478 hasPublicationYear "2022" @default.
- W4289333478 type Work @default.
- W4289333478 citedByCount "0" @default.
- W4289333478 crossrefType "posted-content" @default.
- W4289333478 hasAuthorship W4289333478A5007941660 @default.
- W4289333478 hasAuthorship W4289333478A5030817137 @default.
- W4289333478 hasAuthorship W4289333478A5037413888 @default.
- W4289333478 hasAuthorship W4289333478A5059698457 @default.
- W4289333478 hasAuthorship W4289333478A5066089435 @default.
- W4289333478 hasAuthorship W4289333478A5067542439 @default.
- W4289333478 hasBestOaLocation W42893334781 @default.
- W4289333478 hasConcept C104317684 @default.
- W4289333478 hasConcept C123584848 @default.
- W4289333478 hasConcept C134018914 @default.
- W4289333478 hasConcept C149011108 @default.
- W4289333478 hasConcept C161573976 @default.
- W4289333478 hasConcept C165135838 @default.
- W4289333478 hasConcept C20251656 @default.
- W4289333478 hasConcept C2776441662 @default.
- W4289333478 hasConcept C2776941171 @default.
- W4289333478 hasConcept C2779306644 @default.
- W4289333478 hasConcept C543025807 @default.
- W4289333478 hasConcept C55493867 @default.
- W4289333478 hasConcept C555293320 @default.
- W4289333478 hasConcept C62231903 @default.
- W4289333478 hasConcept C86803240 @default.
- W4289333478 hasConceptScore W4289333478C104317684 @default.
- W4289333478 hasConceptScore W4289333478C123584848 @default.
- W4289333478 hasConceptScore W4289333478C134018914 @default.
- W4289333478 hasConceptScore W4289333478C149011108 @default.
- W4289333478 hasConceptScore W4289333478C161573976 @default.
- W4289333478 hasConceptScore W4289333478C165135838 @default.
- W4289333478 hasConceptScore W4289333478C20251656 @default.
- W4289333478 hasConceptScore W4289333478C2776441662 @default.
- W4289333478 hasConceptScore W4289333478C2776941171 @default.
- W4289333478 hasConceptScore W4289333478C2779306644 @default.
- W4289333478 hasConceptScore W4289333478C543025807 @default.
- W4289333478 hasConceptScore W4289333478C55493867 @default.
- W4289333478 hasConceptScore W4289333478C555293320 @default.
- W4289333478 hasConceptScore W4289333478C62231903 @default.
- W4289333478 hasConceptScore W4289333478C86803240 @default.
- W4289333478 hasLocation W42893334781 @default.
- W4289333478 hasOpenAccess W4289333478 @default.
- W4289333478 hasPrimaryLocation W42893334781 @default.
- W4289333478 hasRelatedWork W1547234870 @default.
- W4289333478 hasRelatedWork W1996365670 @default.
- W4289333478 hasRelatedWork W2079968363 @default.
- W4289333478 hasRelatedWork W2086949087 @default.
- W4289333478 hasRelatedWork W2396685132 @default.
- W4289333478 hasRelatedWork W2575403735 @default.
- W4289333478 hasRelatedWork W3209399639 @default.
- W4289333478 hasRelatedWork W4289333478 @default.
- W4289333478 hasRelatedWork W4297807345 @default.
- W4289333478 hasRelatedWork W4311018832 @default.
- W4289333478 isParatext "false" @default.
- W4289333478 isRetracted "false" @default.
- W4289333478 workType "article" @default.