Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289334508> ?p ?o ?g. }
- W4289334508 endingPage "115197" @default.
- W4289334508 startingPage "115197" @default.
- W4289334508 abstract "Memory CD8+T cells participate in the fight against infection and tumorigenesis as well as in autoimmune disease progression because of their efficient and rapid immune response, long-term survival, and continuous differentiation. At each stage of their formation, maintenance, and function, the cell metabolism must be adjusted to match the functional requirements of the specific stage. Notably, enhanced glycolytic metabolism can generate sufficient levels of adenosine triphosphate (ATP) to form memory CD8+T cells, countering the view that glycolysis prevents the formation of memory CD8+T cells. This review focuses on how glycometabolism regulates memory CD8+T cells and highlights the key mechanisms through which the mammalian target of rapamycin (mTOR) signaling pathway affects memory CD8+T cell formation, maintenance, and function by regulating glycometabolism. In addition, different subpopulations of memory CD8+T cells exhibit different metabolic flexibility during their formation, survival, and functional stages, during which the energy metabolism may be critical. These findings which may explain why enhanced glycolytic metabolism can give rise to memory CD8+T cells. Modulating the metabolism of memory CD8+T cells to influence specific cell fates may be useful for disease treatment." @default.
- W4289334508 created "2022-08-02" @default.
- W4289334508 creator A5006925784 @default.
- W4289334508 creator A5023369582 @default.
- W4289334508 creator A5031068891 @default.
- W4289334508 creator A5034555717 @default.
- W4289334508 creator A5035128620 @default.
- W4289334508 creator A5046145976 @default.
- W4289334508 creator A5052010052 @default.
- W4289334508 creator A5053025795 @default.
- W4289334508 creator A5054402380 @default.
- W4289334508 creator A5065162984 @default.
- W4289334508 creator A5073011320 @default.
- W4289334508 creator A5073124152 @default.
- W4289334508 creator A5075497865 @default.
- W4289334508 creator A5079025070 @default.
- W4289334508 creator A5080765053 @default.
- W4289334508 creator A5083512608 @default.
- W4289334508 date "2022-10-01" @default.
- W4289334508 modified "2023-10-18" @default.
- W4289334508 title "mTOR participates in the formation, maintenance, and function of memory CD8+T cells regulated by glycometabolism" @default.
- W4289334508 cites W1496824237 @default.
- W4289334508 cites W1528382886 @default.
- W4289334508 cites W1563775926 @default.
- W4289334508 cites W1568778024 @default.
- W4289334508 cites W1579635462 @default.
- W4289334508 cites W1584891848 @default.
- W4289334508 cites W1589421810 @default.
- W4289334508 cites W1636607180 @default.
- W4289334508 cites W1857341452 @default.
- W4289334508 cites W1882193637 @default.
- W4289334508 cites W1944753949 @default.
- W4289334508 cites W1967311346 @default.
- W4289334508 cites W1976714959 @default.
- W4289334508 cites W1977336621 @default.
- W4289334508 cites W1980005782 @default.
- W4289334508 cites W1982219839 @default.
- W4289334508 cites W1982257577 @default.
- W4289334508 cites W1983517952 @default.
- W4289334508 cites W1985829345 @default.
- W4289334508 cites W1989357594 @default.
- W4289334508 cites W1990423632 @default.
- W4289334508 cites W1992170852 @default.
- W4289334508 cites W1996539872 @default.
- W4289334508 cites W1999324987 @default.
- W4289334508 cites W2000961821 @default.
- W4289334508 cites W2005996047 @default.
- W4289334508 cites W2008960002 @default.
- W4289334508 cites W2017669223 @default.
- W4289334508 cites W2024074032 @default.
- W4289334508 cites W2024890062 @default.
- W4289334508 cites W2027398476 @default.
- W4289334508 cites W2030378290 @default.
- W4289334508 cites W2033505817 @default.
- W4289334508 cites W2033958147 @default.
- W4289334508 cites W2052090039 @default.
- W4289334508 cites W2061318708 @default.
- W4289334508 cites W2062961514 @default.
- W4289334508 cites W2064876347 @default.
- W4289334508 cites W2065779229 @default.
- W4289334508 cites W2065887259 @default.
- W4289334508 cites W2066379425 @default.
- W4289334508 cites W2069903377 @default.
- W4289334508 cites W2072392441 @default.
- W4289334508 cites W2072820087 @default.
- W4289334508 cites W2074425485 @default.
- W4289334508 cites W2079999658 @default.
- W4289334508 cites W2081826708 @default.
- W4289334508 cites W2083648078 @default.
- W4289334508 cites W2090487323 @default.
- W4289334508 cites W2097259163 @default.
- W4289334508 cites W2102033291 @default.
- W4289334508 cites W2102337360 @default.
- W4289334508 cites W2105697998 @default.
- W4289334508 cites W2115518106 @default.
- W4289334508 cites W2117347105 @default.
- W4289334508 cites W2120521980 @default.
- W4289334508 cites W2121077787 @default.
- W4289334508 cites W2128771042 @default.
- W4289334508 cites W2129424071 @default.
- W4289334508 cites W2130746744 @default.
- W4289334508 cites W2131199230 @default.
- W4289334508 cites W2132667524 @default.
- W4289334508 cites W2144796561 @default.
- W4289334508 cites W2145026575 @default.
- W4289334508 cites W2146791037 @default.
- W4289334508 cites W2151422820 @default.
- W4289334508 cites W2152289580 @default.
- W4289334508 cites W2153607816 @default.
- W4289334508 cites W2157739158 @default.
- W4289334508 cites W2159604413 @default.
- W4289334508 cites W2160551785 @default.
- W4289334508 cites W2162873738 @default.
- W4289334508 cites W2164164239 @default.
- W4289334508 cites W2165891651 @default.
- W4289334508 cites W2177631887 @default.
- W4289334508 cites W2191096966 @default.
- W4289334508 cites W2204680833 @default.