FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289337639> ?p ?o ?g. }

• W4289337639 endingPage "1934" @default.
• W4289337639 startingPage "1926" @default.
• W4289337639 abstract "The relationships between PTEN loss and/or PIK3CA mutation and breast cancer prognosis remain controversial. We aim to examine the associations in large epidemiologic cohorts.We followed women with invasive breast cancer from the Nurses' Health Studies with available data on tumor PTEN expression (n = 4,111) and PIK3CA mutation (n = 2,930). PTEN expression was evaluated by IHC and digitally scored (0%-100%). Pyrosequencing of six hotspot mutations of PIK3CA was performed.We found loss of PTEN expression (≤10%) occurred in 17% of cases, and PIK3CA mutations were detected in 11% of cases. After adjusting for clinical and lifestyle factors, PTEN loss was not associated with worse breast cancer-specific mortality among all samples [HR, 0.85; 95% confidence intervals (CI), 0.71-1.03] or among estrogen receptor (ER)-positive tumors (HR, 0.99; 95% CI, 0.79-1.24). However, among ER-negative tumors, PTEN loss was associated with lower breast cancer-specific mortality (HR, 0.68; 95% CI, 0.48-0.95). PIK3CA mutation was not strongly associated with breast cancer-specific mortality (HR, 0.89; 95% CI, 0.67-1.17). Compared with tumors without PTEN loss and without PIK3CA mutation, those with alterations (n = 540) were not at higher risk (HR, 1.07; 95% CI, 0.86-1.34). However, women with both PTEN loss and PIK3CA mutation (n = 38) were at an increased risk of breast cancer-specific mortality (HR, 1.65; 95% CI, 0.83-3.26).In this large epidemiologic study, the PTEN-mortality association was more pronounced for ER-negative tumors, and the joint PTEN loss and PIK3CA mutation may be associated with worse prognosis.Further studies with a larger sample of ER-negative tumors are needed to replicate our findings and elucidate underlying mechanisms." @default.
• W4289337639 created "2022-08-02" @default.
• W4289337639 creator A5002387956 @default.
• W4289337639 creator A5003432914 @default.
• W4289337639 creator A5013444368 @default.
• W4289337639 creator A5014551852 @default.
• W4289337639 creator A5042507005 @default.
• W4289337639 creator A5049212930 @default.
• W4289337639 creator A5070303359 @default.
• W4289337639 creator A5072834441 @default.
• W4289337639 creator A5073159738 @default.
• W4289337639 creator A5082007246 @default.
• W4289337639 creator A5083991449 @default.
• W4289337639 creator A5084148494 @default.
• W4289337639 creator A5089191285 @default.
• W4289337639 date "2022-08-01" @default.
• W4289337639 modified "2023-09-30" @default.
• W4289337639 title "Loss of PTEN Expression, <i>PIK3CA</i> Mutations, and Breast Cancer Survival in the Nurses’ Health Studies" @default.
• W4289337639 cites W164886646 @default.
• W4289337639 cites W1726767801 @default.
• W4289337639 cites W1978014946 @default.
• W4289337639 cites W1981515448 @default.
• W4289337639 cites W1982204195 @default.
• W4289337639 cites W2008510706 @default.
• W4289337639 cites W2017739035 @default.
• W4289337639 cites W2020372547 @default.
• W4289337639 cites W2029810412 @default.
• W4289337639 cites W2044702943 @default.
• W4289337639 cites W2060397137 @default.
• W4289337639 cites W2073308507 @default.
• W4289337639 cites W2085483616 @default.
• W4289337639 cites W2094586195 @default.
• W4289337639 cites W2096283457 @default.
• W4289337639 cites W2103114638 @default.
• W4289337639 cites W2112499354 @default.
• W4289337639 cites W2122025671 @default.
• W4289337639 cites W2128613144 @default.
• W4289337639 cites W2139587727 @default.
• W4289337639 cites W2140864342 @default.
• W4289337639 cites W2144040817 @default.
• W4289337639 cites W2151258296 @default.
• W4289337639 cites W2152654745 @default.
• W4289337639 cites W2157024383 @default.
• W4289337639 cites W2165661271 @default.
• W4289337639 cites W2169260048 @default.
• W4289337639 cites W2171788965 @default.
• W4289337639 cites W2254497023 @default.
• W4289337639 cites W2292663488 @default.
• W4289337639 cites W2385908186 @default.
• W4289337639 cites W2388163742 @default.
• W4289337639 cites W2405422306 @default.
• W4289337639 cites W2463504723 @default.
• W4289337639 cites W2468052951 @default.
• W4289337639 cites W2556761501 @default.
• W4289337639 cites W2557953210 @default.
• W4289337639 cites W2560367415 @default.
• W4289337639 cites W2587771428 @default.
• W4289337639 cites W2597420951 @default.
• W4289337639 cites W2600264023 @default.
• W4289337639 cites W2788279409 @default.
• W4289337639 cites W2789144897 @default.
• W4289337639 cites W2892334526 @default.
• W4289337639 cites W2897527226 @default.
• W4289337639 cites W2901684825 @default.
• W4289337639 cites W2910558158 @default.
• W4289337639 cites W2941763515 @default.
• W4289337639 cites W3002154893 @default.
• W4289337639 cites W3025589456 @default.
• W4289337639 cites W3087987460 @default.
• W4289337639 cites W3109635877 @default.
• W4289337639 cites W3167827354 @default.
• W4289337639 cites W3192047004 @default.
• W4289337639 cites W342719612 @default.
• W4289337639 cites W4237581718 @default.
• W4289337639 doi "https://doi.org/10.1158/1055-9965.epi-22-0672" @default.
• W4289337639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35914729" @default.
• W4289337639 hasPublicationYear "2022" @default.
• W4289337639 type Work @default.
• W4289337639 citedByCount "0" @default.
• W4289337639 crossrefType "journal-article" @default.
• W4289337639 hasAuthorship W4289337639A5002387956 @default.
• W4289337639 hasAuthorship W4289337639A5003432914 @default.
• W4289337639 hasAuthorship W4289337639A5013444368 @default.
• W4289337639 hasAuthorship W4289337639A5014551852 @default.
• W4289337639 hasAuthorship W4289337639A5042507005 @default.
• W4289337639 hasAuthorship W4289337639A5049212930 @default.
• W4289337639 hasAuthorship W4289337639A5070303359 @default.
• W4289337639 hasAuthorship W4289337639A5072834441 @default.
• W4289337639 hasAuthorship W4289337639A5073159738 @default.
• W4289337639 hasAuthorship W4289337639A5082007246 @default.
• W4289337639 hasAuthorship W4289337639A5083991449 @default.
• W4289337639 hasAuthorship W4289337639A5084148494 @default.
• W4289337639 hasAuthorship W4289337639A5089191285 @default.
• W4289337639 hasBestOaLocation W42893376392 @default.
• W4289337639 hasConcept C121608353 @default.
• W4289337639 hasConcept C126322002 @default.
• W4289337639 hasConcept C143998085 @default.
• W4289337639 hasConcept C2777609662 @default.

• next