FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289339973> ?p ?o ?g. }

• W4289339973 endingPage "100295" @default.
• W4289339973 startingPage "100295" @default.
• W4289339973 abstract "•Hot-spring snakes prefer hot-spring habitats on the Qinghai-Tibet Plateau•Genetic variation in the snakes contribute to the temperature acclimation•Unique mutations in TRPA1 increase thermal sensitivity of the ion channel•Different temperature-sensing strategies existed across snakes Animals have evolved sophisticated temperature-sensing systems and mechanisms to detect and respond to ambient temperature changes. As a relict species endemic to the Qinghai-Tibet Plateau, hot-spring snake (Thermophis baileyi) survived the dramatic changes in climate that occurred during plateau uplift and ice ages, providing an excellent opportunity to explore the evolution of temperature sensation in ectotherms. Based on distributional information and behavioral experiments, we found that T. baileyi prefer hot-spring habitats and respond more quickly to warmth than other two snakes, suggesting that T. baileyi may evolve an efficient thermal-sensing system. Using high-quality chromosome-level assembly and comparative genomic analysis, we identified cold acclimation genes experiencing convergent acceleration in high-altitude lineages. We also discovered significant evolutionary changes in thermosensation- and thermoregulation-related genes, including the transient receptor potential (TRP) channels. Among these genes, TRPA1 exhibited three species-specific amino acid replacements, which differed from those found in infrared imaging snakes, implying different temperature-sensing molecular strategies. Based on laser-heating experiments, the T. baileyi-specific mutations in TRPA1 resulted in an increase in heat-induced opening probability and thermal sensitivity of the ion channels under the same degree of temperature stimulation, which may help the organism respond to temperature changes more quickly. These results provide insight into the genetic mechanisms underpinning the evolution of temperature-sensing strategies in ectotherms as well as genetic evidence of temperature acclimation in this group. Animals have evolved sophisticated temperature-sensing systems and mechanisms to detect and respond to ambient temperature changes. As a relict species endemic to the Qinghai-Tibet Plateau, hot-spring snake (Thermophis baileyi) survived the dramatic changes in climate that occurred during plateau uplift and ice ages, providing an excellent opportunity to explore the evolution of temperature sensation in ectotherms. Based on distributional information and behavioral experiments, we found that T. baileyi prefer hot-spring habitats and respond more quickly to warmth than other two snakes, suggesting that T. baileyi may evolve an efficient thermal-sensing system. Using high-quality chromosome-level assembly and comparative genomic analysis, we identified cold acclimation genes experiencing convergent acceleration in high-altitude lineages. We also discovered significant evolutionary changes in thermosensation- and thermoregulation-related genes, including the transient receptor potential (TRP) channels. Among these genes, TRPA1 exhibited three species-specific amino acid replacements, which differed from those found in infrared imaging snakes, implying different temperature-sensing molecular strategies. Based on laser-heating experiments, the T. baileyi-specific mutations in TRPA1 resulted in an increase in heat-induced opening probability and thermal sensitivity of the ion channels under the same degree of temperature stimulation, which may help the organism respond to temperature changes more quickly. These results provide insight into the genetic mechanisms underpinning the evolution of temperature-sensing strategies in ectotherms as well as genetic evidence of temperature acclimation in this group." @default.
• W4289339973 created "2022-08-02" @default.
• W4289339973 creator A5007670130 @default.
• W4289339973 creator A5028310744 @default.
• W4289339973 creator A5039811048 @default.
• W4289339973 creator A5044053226 @default.
• W4289339973 creator A5062642225 @default.
• W4289339973 creator A5062987221 @default.
• W4289339973 creator A5064918273 @default.
• W4289339973 creator A5065681651 @default.
• W4289339973 date "2022-09-01" @default.
• W4289339973 modified "2023-10-14" @default.
• W4289339973 title "Temperature acclimation in hot-spring snakes and the convergence of cold response" @default.
• W4289339973 cites W1506810639 @default.
• W4289339973 cites W1813348106 @default.
• W4289339973 cites W1963629051 @default.
• W4289339973 cites W1965985711 @default.
• W4289339973 cites W1967906086 @default.
• W4289339973 cites W1981276526 @default.
• W4289339973 cites W1981975859 @default.
• W4289339973 cites W1984533345 @default.
• W4289339973 cites W1987113752 @default.
• W4289339973 cites W1995683486 @default.
• W4289339973 cites W2009880851 @default.
• W4289339973 cites W2017262287 @default.
• W4289339973 cites W2022293360 @default.
• W4289339973 cites W2025379175 @default.
• W4289339973 cites W2027179523 @default.
• W4289339973 cites W2030132879 @default.
• W4289339973 cites W2031848382 @default.
• W4289339973 cites W2034041476 @default.
• W4289339973 cites W2063504935 @default.
• W4289339973 cites W2067878452 @default.
• W4289339973 cites W2081744865 @default.
• W4289339973 cites W2089335658 @default.
• W4289339973 cites W2089523347 @default.
• W4289339973 cites W2096585111 @default.
• W4289339973 cites W2105515899 @default.
• W4289339973 cites W2106207830 @default.
• W4289339973 cites W2109413613 @default.
• W4289339973 cites W2110335151 @default.
• W4289339973 cites W2115809399 @default.
• W4289339973 cites W2120512237 @default.
• W4289339973 cites W2147229999 @default.
• W4289339973 cites W2147652738 @default.
• W4289339973 cites W2149716668 @default.
• W4289339973 cites W2152464393 @default.
• W4289339973 cites W2168315828 @default.
• W4289339973 cites W2210474179 @default.
• W4289339973 cites W2319497272 @default.
• W4289339973 cites W2326331522 @default.
• W4289339973 cites W2402773308 @default.
• W4289339973 cites W2467675961 @default.
• W4289339973 cites W2519344407 @default.
• W4289339973 cites W2538767949 @default.
• W4289339973 cites W2586468758 @default.
• W4289339973 cites W2604697573 @default.
• W4289339973 cites W2734545316 @default.
• W4289339973 cites W2765629363 @default.
• W4289339973 cites W2791545805 @default.
• W4289339973 cites W2794074646 @default.
• W4289339973 cites W2796718751 @default.
• W4289339973 cites W2827056258 @default.
• W4289339973 cites W2886639598 @default.
• W4289339973 cites W2903214769 @default.
• W4289339973 cites W2911573918 @default.
• W4289339973 cites W2947850854 @default.
• W4289339973 cites W2987171999 @default.
• W4289339973 cites W2994970765 @default.
• W4289339973 cites W3013007514 @default.
• W4289339973 cites W3093764162 @default.
• W4289339973 cites W3159994604 @default.
• W4289339973 cites W3214064918 @default.
• W4289339973 cites W4200096582 @default.
• W4289339973 doi "https://doi.org/10.1016/j.xinn.2022.100295" @default.
• W4289339973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36032194" @default.
• W4289339973 hasPublicationYear "2022" @default.
• W4289339973 type Work @default.
• W4289339973 citedByCount "4" @default.
• W4289339973 countsByYear W42893399732022 @default.
• W4289339973 countsByYear W42893399732023 @default.
• W4289339973 crossrefType "journal-article" @default.
• W4289339973 hasAuthorship W4289339973A5007670130 @default.
• W4289339973 hasAuthorship W4289339973A5028310744 @default.
• W4289339973 hasAuthorship W4289339973A5039811048 @default.
• W4289339973 hasAuthorship W4289339973A5044053226 @default.
• W4289339973 hasAuthorship W4289339973A5062642225 @default.
• W4289339973 hasAuthorship W4289339973A5062987221 @default.
• W4289339973 hasAuthorship W4289339973A5064918273 @default.
• W4289339973 hasAuthorship W4289339973A5065681651 @default.
• W4289339973 hasBestOaLocation W42893399731 @default.
• W4289339973 hasConcept C100564792 @default.
• W4289339973 hasConcept C119406331 @default.
• W4289339973 hasConcept C13376991 @default.
• W4289339973 hasConcept C134306372 @default.
• W4289339973 hasConcept C139807058 @default.
• W4289339973 hasConcept C151730666 @default.
• W4289339973 hasConcept C169760540 @default.

• next