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- W4289341729 endingPage "C782" @default.
- W4289341729 startingPage "C772" @default.
- W4289341729 abstract "Channel proteins are vital for conducting ions throughout the body and are especially relevant to retina physiology. Inward rectifier potassium (Kir) channels are a class of K+ channels responsible for maintaining membrane potential and extracellular K+ concentrations. Studies of the KCNJ gene (that encodes Kir protein) expression identified the presence of all of the subclasses (Kir 1-7) of Kir channels in the retina or retinal-pigmented epithelium (RPE). However, functional studies have established the involvement of the Kir4.1 homotetramer and Kir4.1/5.1 heterotetramer in Müller glial cells, Kir2.1 in bipolar cells, and Kir7.1 in the RPE cell physiology. Here, we propose the potential roles of Kir channels in the retina based on the physiological contributions to the brain, pancreatic, and cardiac tissue functions. There are several open questions regarding the expressed KCNJ genes in the retina and RPE. For example, why does not the Kir channel subtype gene expression correspond with protein expression? Catching up with multiomics or functional omics approaches might shed light on posttranscriptional changes that might influence Kir subunit mRNA translation within the retina that guides our vision." @default.
- W4289341729 created "2022-08-02" @default.
- W4289341729 creator A5034234543 @default.
- W4289341729 creator A5046709507 @default.
- W4289341729 date "2022-09-01" @default.
- W4289341729 modified "2023-09-23" @default.
- W4289341729 title "Inward rectifier potassium (Kir) channels in the retina: living our vision" @default.
- W4289341729 cites W1538850399 @default.
- W4289341729 cites W1585589304 @default.
- W4289341729 cites W1673813955 @default.
- W4289341729 cites W1817282084 @default.
- W4289341729 cites W1900482019 @default.
- W4289341729 cites W1914791833 @default.
- W4289341729 cites W1931176429 @default.
- W4289341729 cites W1963789911 @default.
- W4289341729 cites W1964403826 @default.
- W4289341729 cites W1971388908 @default.
- W4289341729 cites W1974853045 @default.
- W4289341729 cites W1976731196 @default.
- W4289341729 cites W1982103659 @default.
- W4289341729 cites W1984372305 @default.
- W4289341729 cites W1984625729 @default.
- W4289341729 cites W1986272392 @default.
- W4289341729 cites W1987339646 @default.
- W4289341729 cites W1987549181 @default.
- W4289341729 cites W1988016076 @default.
- W4289341729 cites W1992416493 @default.
- W4289341729 cites W1992910123 @default.
- W4289341729 cites W1995433786 @default.
- W4289341729 cites W1999589789 @default.
- W4289341729 cites W2000756205 @default.
- W4289341729 cites W2007029779 @default.
- W4289341729 cites W2017263107 @default.
- W4289341729 cites W2017310720 @default.
- W4289341729 cites W2018256150 @default.
- W4289341729 cites W2020083484 @default.
- W4289341729 cites W2022122180 @default.
- W4289341729 cites W2022813713 @default.
- W4289341729 cites W2023453938 @default.
- W4289341729 cites W2027564630 @default.
- W4289341729 cites W2028023737 @default.
- W4289341729 cites W2029062076 @default.
- W4289341729 cites W2030987120 @default.
- W4289341729 cites W2032504293 @default.
- W4289341729 cites W2032927431 @default.
- W4289341729 cites W2034259511 @default.
- W4289341729 cites W2034675173 @default.
- W4289341729 cites W2039974278 @default.
- W4289341729 cites W2040856928 @default.
- W4289341729 cites W2043249715 @default.
- W4289341729 cites W2047158226 @default.
- W4289341729 cites W2048988573 @default.
- W4289341729 cites W2049036672 @default.
- W4289341729 cites W2050014848 @default.
- W4289341729 cites W2054437976 @default.
- W4289341729 cites W2057657886 @default.
- W4289341729 cites W2058483899 @default.
- W4289341729 cites W2063406006 @default.
- W4289341729 cites W2063842064 @default.
- W4289341729 cites W2069699972 @default.
- W4289341729 cites W2073440103 @default.
- W4289341729 cites W2075205205 @default.
- W4289341729 cites W2077176975 @default.
- W4289341729 cites W2077708836 @default.
- W4289341729 cites W2078217942 @default.
- W4289341729 cites W2079163382 @default.
- W4289341729 cites W2080639235 @default.
- W4289341729 cites W2080707422 @default.
- W4289341729 cites W2083799333 @default.
- W4289341729 cites W2084517131 @default.
- W4289341729 cites W2084575920 @default.
- W4289341729 cites W2085157607 @default.
- W4289341729 cites W2089450477 @default.
- W4289341729 cites W2090570062 @default.
- W4289341729 cites W2093856123 @default.
- W4289341729 cites W2106781585 @default.
- W4289341729 cites W2107598022 @default.
- W4289341729 cites W2110817316 @default.
- W4289341729 cites W2113423267 @default.
- W4289341729 cites W2115101062 @default.
- W4289341729 cites W2123138919 @default.
- W4289341729 cites W2123558014 @default.
- W4289341729 cites W2124603749 @default.
- W4289341729 cites W2125864491 @default.
- W4289341729 cites W2128345520 @default.
- W4289341729 cites W2139222531 @default.
- W4289341729 cites W2141321445 @default.
- W4289341729 cites W2143389504 @default.
- W4289341729 cites W2144652878 @default.
- W4289341729 cites W2148181502 @default.
- W4289341729 cites W2150912702 @default.
- W4289341729 cites W2154122229 @default.
- W4289341729 cites W2154892238 @default.
- W4289341729 cites W2157572296 @default.
- W4289341729 cites W2157788198 @default.
- W4289341729 cites W2160845018 @default.
- W4289341729 cites W2160941824 @default.
- W4289341729 cites W2161227647 @default.