Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289341937> ?p ?o ?g. }
- W4289341937 endingPage "C790" @default.
- W4289341937 startingPage "C783" @default.
- W4289341937 abstract "The canonical model for G protein-coupled receptors (GPCRs) activation assumes that stimulation of heterotrimeric G protein signaling upon ligand binding occurs solely at the cell surface and that duration of the stimulation is transient to prevent overstimulation. In this model, GPCR signaling is turned-off by receptor phosphorylation via GPCR kinases (GRKs) and subsequent recruitment of β-arrestins, resulting in receptor internalization into endosomes. Internalized receptors can then recycle back to the cell surface or be trafficked to lysosomes for degradation. However, over the last decade, this model has been extended by discovering that some internalized GPCRs continue to signal via G proteins from endosomes. This is the case for the parathyroid hormone (PTH) type 1 receptor (PTHR), which engages on sustained cAMP signaling from endosomes upon PTH stimulation. Accumulative evidence shows that the location of signaling has an impact on the physiological effects of GPCR signaling. This mini-review discusses recent insights into the mechanisms of PTHR endosomal signaling and its physiological impact." @default.
- W4289341937 created "2022-08-02" @default.
- W4289341937 creator A5077792274 @default.
- W4289341937 date "2022-09-01" @default.
- W4289341937 modified "2023-10-16" @default.
- W4289341937 title "Endosomal parathyroid hormone receptor signaling" @default.
- W4289341937 cites W1921707426 @default.
- W4289341937 cites W1971748110 @default.
- W4289341937 cites W1988891187 @default.
- W4289341937 cites W1994287472 @default.
- W4289341937 cites W2005999997 @default.
- W4289341937 cites W2009672068 @default.
- W4289341937 cites W2012895196 @default.
- W4289341937 cites W2022294588 @default.
- W4289341937 cites W2024895303 @default.
- W4289341937 cites W2035770843 @default.
- W4289341937 cites W2041050634 @default.
- W4289341937 cites W2043915166 @default.
- W4289341937 cites W2058407325 @default.
- W4289341937 cites W2060346226 @default.
- W4289341937 cites W2061098391 @default.
- W4289341937 cites W2067080420 @default.
- W4289341937 cites W2067973462 @default.
- W4289341937 cites W2082817154 @default.
- W4289341937 cites W2083068026 @default.
- W4289341937 cites W2094013515 @default.
- W4289341937 cites W2111112233 @default.
- W4289341937 cites W2120926135 @default.
- W4289341937 cites W2124572912 @default.
- W4289341937 cites W2125692373 @default.
- W4289341937 cites W2126202517 @default.
- W4289341937 cites W2130536801 @default.
- W4289341937 cites W2141777375 @default.
- W4289341937 cites W2141894196 @default.
- W4289341937 cites W2153229537 @default.
- W4289341937 cites W2176994106 @default.
- W4289341937 cites W2262581704 @default.
- W4289341937 cites W2282509280 @default.
- W4289341937 cites W2307384627 @default.
- W4289341937 cites W2311603971 @default.
- W4289341937 cites W2531618378 @default.
- W4289341937 cites W2552634635 @default.
- W4289341937 cites W2737465566 @default.
- W4289341937 cites W2767140579 @default.
- W4289341937 cites W2792843706 @default.
- W4289341937 cites W2797350306 @default.
- W4289341937 cites W2901348230 @default.
- W4289341937 cites W2913698238 @default.
- W4289341937 cites W2917973990 @default.
- W4289341937 cites W2939681516 @default.
- W4289341937 cites W2947521908 @default.
- W4289341937 cites W2971425966 @default.
- W4289341937 cites W2973504822 @default.
- W4289341937 cites W3008004932 @default.
- W4289341937 cites W3012333171 @default.
- W4289341937 cites W3036711312 @default.
- W4289341937 cites W3038664152 @default.
- W4289341937 cites W3174142416 @default.
- W4289341937 cites W3198268411 @default.
- W4289341937 cites W3203911755 @default.
- W4289341937 cites W4206615517 @default.
- W4289341937 cites W4289261754 @default.
- W4289341937 doi "https://doi.org/10.1152/ajpcell.00452.2021" @default.
- W4289341937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35912987" @default.
- W4289341937 hasPublicationYear "2022" @default.
- W4289341937 type Work @default.
- W4289341937 citedByCount "2" @default.
- W4289341937 countsByYear W42893419372023 @default.
- W4289341937 crossrefType "journal-article" @default.
- W4289341937 hasAuthorship W4289341937A5077792274 @default.
- W4289341937 hasConcept C102747710 @default.
- W4289341937 hasConcept C11960822 @default.
- W4289341937 hasConcept C135285700 @default.
- W4289341937 hasConcept C139407321 @default.
- W4289341937 hasConcept C139770010 @default.
- W4289341937 hasConcept C150555746 @default.
- W4289341937 hasConcept C170493617 @default.
- W4289341937 hasConcept C178790620 @default.
- W4289341937 hasConcept C185592680 @default.
- W4289341937 hasConcept C2781208988 @default.
- W4289341937 hasConcept C33235085 @default.
- W4289341937 hasConcept C519063684 @default.
- W4289341937 hasConcept C55493867 @default.
- W4289341937 hasConcept C62478195 @default.
- W4289341937 hasConcept C79879829 @default.
- W4289341937 hasConcept C80631254 @default.
- W4289341937 hasConcept C86803240 @default.
- W4289341937 hasConcept C95444343 @default.
- W4289341937 hasConceptScore W4289341937C102747710 @default.
- W4289341937 hasConceptScore W4289341937C11960822 @default.
- W4289341937 hasConceptScore W4289341937C135285700 @default.
- W4289341937 hasConceptScore W4289341937C139407321 @default.
- W4289341937 hasConceptScore W4289341937C139770010 @default.
- W4289341937 hasConceptScore W4289341937C150555746 @default.
- W4289341937 hasConceptScore W4289341937C170493617 @default.
- W4289341937 hasConceptScore W4289341937C178790620 @default.
- W4289341937 hasConceptScore W4289341937C185592680 @default.
- W4289341937 hasConceptScore W4289341937C2781208988 @default.