Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289346314> ?p ?o ?g. }
- W4289346314 abstract "Estrogen and progesterone specify the establishment of uterine receptivity mainly through their respective nuclear receptors, ER and PR. PR is transcriptionally induced by estrogen-ER signaling in the endometrium, but how the protein homeostasis of PR in the endometrium is regulated remains elusive. Here, we demonstrated that the uterine-selective depletion of P38α derails normal uterine receptivity ascribed to the dramatic down-regulation of PR protein and disordered progesterone responsiveness in the uterine stromal compartment, leading to defective implantation and female infertility. Specifically, Ube3c, an HECT family E3 ubiquitin ligase, targets PR for polyubiquitination and thus proteasome degradation in the absence of P38α. Moreover, we discovered that P38α restrains the polyubiquitination activity of Ube3c toward PR by phosphorylating the Ube3c at serine741 . In summary, we provided genetic evidence for the regulation of PR protein stability in the endometrium by P38α and identified Ube3c, whose activity was modulated by P38α-mediated phosphorylation, as an E3 ubiquitin ligase for PR in the uterus." @default.
- W4289346314 created "2022-08-02" @default.
- W4289346314 creator A5000235097 @default.
- W4289346314 creator A5003642180 @default.
- W4289346314 creator A5011928383 @default.
- W4289346314 creator A5018381050 @default.
- W4289346314 creator A5040840380 @default.
- W4289346314 creator A5050479872 @default.
- W4289346314 creator A5056484501 @default.
- W4289346314 creator A5059363182 @default.
- W4289346314 creator A5068017350 @default.
- W4289346314 creator A5076847335 @default.
- W4289346314 creator A5080521336 @default.
- W4289346314 creator A5083348278 @default.
- W4289346314 creator A5083371291 @default.
- W4289346314 date "2022-08-01" @default.
- W4289346314 modified "2023-10-17" @default.
- W4289346314 title "P38α MAPK is a gatekeeper of uterine progesterone responsiveness at peri-implantation via Ube3c-mediated PGR degradation" @default.
- W4289346314 cites W1965853166 @default.
- W4289346314 cites W1975974673 @default.
- W4289346314 cites W1988031203 @default.
- W4289346314 cites W1990498979 @default.
- W4289346314 cites W1993494912 @default.
- W4289346314 cites W1994256819 @default.
- W4289346314 cites W1995038819 @default.
- W4289346314 cites W1996975584 @default.
- W4289346314 cites W2001983551 @default.
- W4289346314 cites W2005941221 @default.
- W4289346314 cites W2006494078 @default.
- W4289346314 cites W2011214996 @default.
- W4289346314 cites W2032202789 @default.
- W4289346314 cites W2034475021 @default.
- W4289346314 cites W2036145275 @default.
- W4289346314 cites W2041063291 @default.
- W4289346314 cites W2054555143 @default.
- W4289346314 cites W2064624330 @default.
- W4289346314 cites W2079749507 @default.
- W4289346314 cites W2080433518 @default.
- W4289346314 cites W2082559087 @default.
- W4289346314 cites W2100438302 @default.
- W4289346314 cites W2108475046 @default.
- W4289346314 cites W2124121505 @default.
- W4289346314 cites W2144099695 @default.
- W4289346314 cites W2148734624 @default.
- W4289346314 cites W2149848093 @default.
- W4289346314 cites W2150278759 @default.
- W4289346314 cites W2158240057 @default.
- W4289346314 cites W2164096066 @default.
- W4289346314 cites W2164576139 @default.
- W4289346314 cites W2290757393 @default.
- W4289346314 cites W2583201344 @default.
- W4289346314 cites W2763528155 @default.
- W4289346314 cites W2769775758 @default.
- W4289346314 cites W2802249369 @default.
- W4289346314 cites W2808923566 @default.
- W4289346314 cites W2963000716 @default.
- W4289346314 cites W2965741381 @default.
- W4289346314 cites W2972274167 @default.
- W4289346314 cites W3006583025 @default.
- W4289346314 cites W3087660137 @default.
- W4289346314 cites W3132356773 @default.
- W4289346314 cites W4211072069 @default.
- W4289346314 cites W4221073798 @default.
- W4289346314 doi "https://doi.org/10.1073/pnas.2206000119" @default.
- W4289346314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35914132" @default.
- W4289346314 hasPublicationYear "2022" @default.
- W4289346314 type Work @default.
- W4289346314 citedByCount "5" @default.
- W4289346314 countsByYear W42893463142022 @default.
- W4289346314 countsByYear W42893463142023 @default.
- W4289346314 crossrefType "journal-article" @default.
- W4289346314 hasAuthorship W4289346314A5000235097 @default.
- W4289346314 hasAuthorship W4289346314A5003642180 @default.
- W4289346314 hasAuthorship W4289346314A5011928383 @default.
- W4289346314 hasAuthorship W4289346314A5018381050 @default.
- W4289346314 hasAuthorship W4289346314A5040840380 @default.
- W4289346314 hasAuthorship W4289346314A5050479872 @default.
- W4289346314 hasAuthorship W4289346314A5056484501 @default.
- W4289346314 hasAuthorship W4289346314A5059363182 @default.
- W4289346314 hasAuthorship W4289346314A5068017350 @default.
- W4289346314 hasAuthorship W4289346314A5076847335 @default.
- W4289346314 hasAuthorship W4289346314A5080521336 @default.
- W4289346314 hasAuthorship W4289346314A5083348278 @default.
- W4289346314 hasAuthorship W4289346314A5083371291 @default.
- W4289346314 hasBestOaLocation W42893463141 @default.
- W4289346314 hasConcept C104317684 @default.
- W4289346314 hasConcept C11960822 @default.
- W4289346314 hasConcept C121608353 @default.
- W4289346314 hasConcept C126322002 @default.
- W4289346314 hasConcept C134018914 @default.
- W4289346314 hasConcept C134459356 @default.
- W4289346314 hasConcept C172313692 @default.
- W4289346314 hasConcept C185592680 @default.
- W4289346314 hasConcept C25602115 @default.
- W4289346314 hasConcept C2777164284 @default.
- W4289346314 hasConcept C2779742232 @default.
- W4289346314 hasConcept C51551487 @default.
- W4289346314 hasConcept C530470458 @default.
- W4289346314 hasConcept C55493867 @default.
- W4289346314 hasConcept C57074206 @default.