FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289346360> ?p ?o ?g. }

• W4289346360 endingPage "159208" @default.
• W4289346360 startingPage "159208" @default.
• W4289346360 abstract "The small intestine is a highly adaptable organ serving as both a barrier to the external environment and a conduit for nutrient absorption. Enterocytes package dietary triglycerides (TG) into chylomicrons for transport into circulation; the remaining TGs are stored in cytosolic lipid droplets (CLDs). The current study aimed to characterize the impact of diet composition on intestinal lipid handling in male and female wild-type mice. Mice were continued on their grain-based diet (GBD) and switched to either a high-fat, high cholesterol Western-style diet (WD) or a ketogenic diet (KD) for 3 or 5 weeks. KD-fed mice displayed significantly higher plasma TG levels in response to an olive oil gavage than WD- and GBD-fed mice; TG levels were ~2-fold higher in male KD-fed mice than female KD-fed mice. Poloxamer-407 experiments revealed enhanced intestinal-TG secretion rates in male mice fed a KD upon olive oil gavage, whereas secretion rates were unchanged in female mice. Surprisingly, jejunal CLD size and TG mass after oil gavage were similar among the groups. At fasting, TG mass was significantly higher in the jejunum of male KD-fed mice and the duodenum of female KD-fed mice, providing increased substrate for chylomicron formation. In addition to greater fasting intestinal TG stores, KD-fed male mice displayed longer small intestinal lengths, while female mice displayed markedly longer jejunal villi lengths. After 5 weeks of diet, 12 h fasting-2 h refeeding experiments revealed jejunal TG levels were similar between diet groups in male mice; however, in female mice, jejunal TG mass was significantly higher in KD-fed mice compared to GBD- and WD-fed mice. These experiments reveal that KD feeding promotes distinct morphological and functional changes to the murine small intestine compared to the WD diet. Moreover, changes to intestinal lipid handling in response to carbohydrate and protein restriction manifest differently in male and female mice." @default.
• W4289346360 created "2022-08-02" @default.
• W4289346360 creator A5024168823 @default.
• W4289346360 creator A5024464784 @default.
• W4289346360 creator A5031515530 @default.
• W4289346360 creator A5033087712 @default.
• W4289346360 creator A5034733467 @default.
• W4289346360 creator A5054857127 @default.
• W4289346360 creator A5061123220 @default.
• W4289346360 creator A5066065033 @default.
• W4289346360 creator A5077325037 @default.
• W4289346360 creator A5083704267 @default.
• W4289346360 creator A5088820828 @default.
• W4289346360 date "2022-11-01" @default.
• W4289346360 modified "2023-10-06" @default.
• W4289346360 title "Adaptation to short-term extreme fat consumption alters intestinal lipid handling in male and female mice" @default.
• W4289346360 cites W1531695174 @default.
• W4289346360 cites W1973818778 @default.
• W4289346360 cites W1975365111 @default.
• W4289346360 cites W1977144451 @default.
• W4289346360 cites W1990714106 @default.
• W4289346360 cites W1992335884 @default.
• W4289346360 cites W1998719511 @default.
• W4289346360 cites W2019441179 @default.
• W4289346360 cites W2025685696 @default.
• W4289346360 cites W2049520707 @default.
• W4289346360 cites W2055582936 @default.
• W4289346360 cites W2058749852 @default.
• W4289346360 cites W2083775524 @default.
• W4289346360 cites W2096478712 @default.
• W4289346360 cites W2103719835 @default.
• W4289346360 cites W2113757170 @default.
• W4289346360 cites W2114695967 @default.
• W4289346360 cites W2115632619 @default.
• W4289346360 cites W2130016382 @default.
• W4289346360 cites W2135480224 @default.
• W4289346360 cites W2143440758 @default.
• W4289346360 cites W2258043395 @default.
• W4289346360 cites W2460600979 @default.
• W4289346360 cites W2587156779 @default.
• W4289346360 cites W2732637235 @default.
• W4289346360 cites W2767512583 @default.
• W4289346360 cites W2792260658 @default.
• W4289346360 cites W2809420247 @default.
• W4289346360 cites W2883213315 @default.
• W4289346360 cites W2888188466 @default.
• W4289346360 cites W2897080090 @default.
• W4289346360 cites W2920304894 @default.
• W4289346360 cites W2952265007 @default.
• W4289346360 cites W2960838833 @default.
• W4289346360 cites W2969784858 @default.
• W4289346360 cites W2991023589 @default.
• W4289346360 cites W3004350202 @default.
• W4289346360 cites W3012791221 @default.
• W4289346360 cites W3013007519 @default.
• W4289346360 cites W3048264818 @default.
• W4289346360 cites W3085137158 @default.
• W4289346360 cites W3160482293 @default.
• W4289346360 cites W3194553971 @default.
• W4289346360 cites W3215391992 @default.
• W4289346360 cites W4200549846 @default.
• W4289346360 doi "https://doi.org/10.1016/j.bbalip.2022.159208" @default.
• W4289346360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35926775" @default.
• W4289346360 hasPublicationYear "2022" @default.
• W4289346360 type Work @default.
• W4289346360 citedByCount "1" @default.
• W4289346360 crossrefType "journal-article" @default.
• W4289346360 hasAuthorship W4289346360A5024168823 @default.
• W4289346360 hasAuthorship W4289346360A5024464784 @default.
• W4289346360 hasAuthorship W4289346360A5031515530 @default.
• W4289346360 hasAuthorship W4289346360A5033087712 @default.
• W4289346360 hasAuthorship W4289346360A5034733467 @default.
• W4289346360 hasAuthorship W4289346360A5054857127 @default.
• W4289346360 hasAuthorship W4289346360A5061123220 @default.
• W4289346360 hasAuthorship W4289346360A5066065033 @default.
• W4289346360 hasAuthorship W4289346360A5077325037 @default.
• W4289346360 hasAuthorship W4289346360A5083704267 @default.
• W4289346360 hasAuthorship W4289346360A5088820828 @default.
• W4289346360 hasBestOaLocation W42893463601 @default.
• W4289346360 hasConcept C11772777 @default.
• W4289346360 hasConcept C126322002 @default.
• W4289346360 hasConcept C134018914 @default.
• W4289346360 hasConcept C185592680 @default.
• W4289346360 hasConcept C2776366702 @default.
• W4289346360 hasConcept C2776809568 @default.
• W4289346360 hasConcept C2777226302 @default.
• W4289346360 hasConcept C2777882243 @default.
• W4289346360 hasConcept C2778163477 @default.
• W4289346360 hasConcept C2778206080 @default.
• W4289346360 hasConcept C2780072125 @default.
• W4289346360 hasConcept C71924100 @default.
• W4289346360 hasConcept C8243546 @default.
• W4289346360 hasConcept C86803240 @default.
• W4289346360 hasConceptScore W4289346360C11772777 @default.
• W4289346360 hasConceptScore W4289346360C126322002 @default.
• W4289346360 hasConceptScore W4289346360C134018914 @default.
• W4289346360 hasConceptScore W4289346360C185592680 @default.
• W4289346360 hasConceptScore W4289346360C2776366702 @default.

• next