Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289346375> ?p ?o ?g. }
- W4289346375 endingPage "318" @default.
- W4289346375 startingPage "304" @default.
- W4289346375 abstract "Silicosis, induced by inhaling silica particles in workplaces, is one of the most common occupational diseases. The prognosis of silicosis and its consequent fibrosis is extremely poor due to limited treatment modalities and lack of understanding of the disease mechanisms. In this study, a Wistar rat model for silicosis fibrosis was established by intratracheal instillation of silica (0, 50, 100 and 200 mg/mL, 1 mL) with the evidence of Hematoxylin and Eosin (HE) and Masson staining and the expressions of inflammatory and fibrotic proteins of rats' lung tissues. RNA of lung tissues of rats exposed to 200 mg/mL silica particles and normal saline for 14 d and 28 d was extracted and sequenced to detect differentially expressed genes (DEGs) and to identify silicosis fibrosis-associated modules and hub genes by Weighted gene co-expression network analysis (WGCNA). Predictions of gene functions and signaling pathways were conducted using Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) databases. In this study, it has been demonstrated the promising role of the Hippo signaling pathway in silicosis fibrosis, which will be conducive to elucidating the specific mechanism of pulmonary fibrosis induced by silica and to determining molecular initiating event (MIE) and adverse outcome pathway (AOP) of silicosis fibrosis." @default.
- W4289346375 created "2022-08-02" @default.
- W4289346375 creator A5001628338 @default.
- W4289346375 creator A5017189049 @default.
- W4289346375 creator A5019149927 @default.
- W4289346375 creator A5021384155 @default.
- W4289346375 creator A5023132715 @default.
- W4289346375 creator A5033154908 @default.
- W4289346375 creator A5034654778 @default.
- W4289346375 creator A5037332709 @default.
- W4289346375 creator A5042310701 @default.
- W4289346375 creator A5044544424 @default.
- W4289346375 creator A5048274582 @default.
- W4289346375 creator A5057780725 @default.
- W4289346375 creator A5063481044 @default.
- W4289346375 creator A5063683079 @default.
- W4289346375 creator A5067093084 @default.
- W4289346375 creator A5068714569 @default.
- W4289346375 creator A5069548541 @default.
- W4289346375 creator A5071413619 @default.
- W4289346375 creator A5075812383 @default.
- W4289346375 date "2022-08-01" @default.
- W4289346375 modified "2023-10-04" @default.
- W4289346375 title "Identification of key pathways and genes in the progression of silicosis based on WGCNA" @default.
- W4289346375 cites W1483118820 @default.
- W4289346375 cites W1615542914 @default.
- W4289346375 cites W1749982858 @default.
- W4289346375 cites W1819171550 @default.
- W4289346375 cites W1966327575 @default.
- W4289346375 cites W1974033269 @default.
- W4289346375 cites W1993493586 @default.
- W4289346375 cites W2023404925 @default.
- W4289346375 cites W2060705109 @default.
- W4289346375 cites W2064540966 @default.
- W4289346375 cites W2067489401 @default.
- W4289346375 cites W2083027206 @default.
- W4289346375 cites W2090544197 @default.
- W4289346375 cites W2091625509 @default.
- W4289346375 cites W2091913641 @default.
- W4289346375 cites W2148056172 @default.
- W4289346375 cites W2148992213 @default.
- W4289346375 cites W2168072233 @default.
- W4289346375 cites W2340585968 @default.
- W4289346375 cites W2347091783 @default.
- W4289346375 cites W2390822022 @default.
- W4289346375 cites W2411419987 @default.
- W4289346375 cites W2595525832 @default.
- W4289346375 cites W2605486969 @default.
- W4289346375 cites W2791900271 @default.
- W4289346375 cites W2807757515 @default.
- W4289346375 cites W2890382099 @default.
- W4289346375 cites W2891072035 @default.
- W4289346375 cites W2898553729 @default.
- W4289346375 cites W2909794188 @default.
- W4289346375 cites W2922278038 @default.
- W4289346375 cites W2940067330 @default.
- W4289346375 cites W2948934315 @default.
- W4289346375 cites W2973131625 @default.
- W4289346375 cites W3003588559 @default.
- W4289346375 cites W3004227212 @default.
- W4289346375 cites W3011169619 @default.
- W4289346375 cites W3014539827 @default.
- W4289346375 cites W3023486162 @default.
- W4289346375 cites W3036513507 @default.
- W4289346375 cites W3039934655 @default.
- W4289346375 cites W3040195630 @default.
- W4289346375 cites W3044810201 @default.
- W4289346375 cites W3045857778 @default.
- W4289346375 cites W3111228261 @default.
- W4289346375 cites W3111410363 @default.
- W4289346375 cites W3122690891 @default.
- W4289346375 cites W3126424407 @default.
- W4289346375 cites W3148618465 @default.
- W4289346375 cites W3176596611 @default.
- W4289346375 cites W3187383871 @default.
- W4289346375 cites W3208196779 @default.
- W4289346375 cites W3208727094 @default.
- W4289346375 cites W4211204057 @default.
- W4289346375 doi "https://doi.org/10.1080/08958378.2022.2102700" @default.
- W4289346375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35913820" @default.
- W4289346375 hasPublicationYear "2022" @default.
- W4289346375 type Work @default.
- W4289346375 citedByCount "3" @default.
- W4289346375 countsByYear W42893463752022 @default.
- W4289346375 countsByYear W42893463752023 @default.
- W4289346375 crossrefType "journal-article" @default.
- W4289346375 hasAuthorship W4289346375A5001628338 @default.
- W4289346375 hasAuthorship W4289346375A5017189049 @default.
- W4289346375 hasAuthorship W4289346375A5019149927 @default.
- W4289346375 hasAuthorship W4289346375A5021384155 @default.
- W4289346375 hasAuthorship W4289346375A5023132715 @default.
- W4289346375 hasAuthorship W4289346375A5033154908 @default.
- W4289346375 hasAuthorship W4289346375A5034654778 @default.
- W4289346375 hasAuthorship W4289346375A5037332709 @default.
- W4289346375 hasAuthorship W4289346375A5042310701 @default.
- W4289346375 hasAuthorship W4289346375A5044544424 @default.
- W4289346375 hasAuthorship W4289346375A5048274582 @default.
- W4289346375 hasAuthorship W4289346375A5057780725 @default.