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- W4289443344 abstract "Abstract Background Extrinsic molecular mechanisms that regulate hematopoietic stem/progenitor cell (HSPC) aging are still poorly understood, and a potential protective medication needs to be explored. Materials and Methods The senescent parameters of hematopoietic cells and bone marrow stromal cells (BMSCs) including cell cycle analysis, senescence-associated SA-β-gal staining and signals, hematopoietic factors and cellular junction were analyzed in femur and tibia of rats. Furthermore, Sca-1 + HSPCs and BMSCs co-culture system was established to evaluate the direct effects of BMSC feeder layer to HSPCs. Oxidative DNA damage indicators in Sca-1 + HSCs and senescence-associated secretory phenotype (SASP) of BMSCs, gap junction intercellular communication between BMSCs, osteogenesis/adipogenisis differentiation balance of BMSCs were detected. Results In the D-gal pre-administrated rats, ASP treatment rescued senescence of hematopoietic cells and BMSCs, reserved CFU-GEMM; also, ASP treatment attenuated stromal oxidative load, ameliorated SCF, CXCL12, and GM-CSF production, increased Connexin-43 (Cx43) expression. BMSCs and Sca-1 + HSPCs co-cultivation demonstrated that ASP treatment prevented oxidative DNA damage response in co-cultured Sca-1 + HSPCs induced by D-gal pre-administration of feeder layer and the underlying mechanism may be related to ASP ameliorating feeder layer dysfunction due to D-gal induced senescence via inhibiting secretion of IL-1, IL-6, TNF-α, and RANTES, enhancing Cx43-mediated intercellular communication, improving Runx2 expression whereas decreasing PPARγ expression in BMSCs. Conclusions The antioxidant property of ASP may provide a stroma-mediated potential therapeutic strategy for HSPC aging." @default.
- W4289443344 created "2022-08-02" @default.
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- W4289443344 date "2022-08-02" @default.
- W4289443344 modified "2023-09-28" @default.
- W4289443344 title "Angelica Sinensis Polysaccharides Prevents Hematopoietic Regression in D-Galactose-Induced Aging Model via Attenuation of Oxidative Stress in Hematopoietic Microenvironment" @default.
- W4289443344 doi "https://doi.org/10.21203/rs.3.rs-1872332/v1" @default.
- W4289443344 hasPublicationYear "2022" @default.
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