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- W4289443375 abstract "Abstract The aim of this study was to explore the effect of capsaicin and particular phenolic compounds profile from cellulase assisted extracts of Habanero ( Capsicum chinense ) chili pepper seeds (CPS) on the concentration of cytokines (IL-2, IL-6, TNF-α, IL-1β) in murine macrophages (RAW 264.7) stimulated with lipopolysaccharides (LPS). Capsaicin was quantified by HPLC-DAD, and the phenolic profile was determined by UPLC-MS-QqQ. Anti-inflammatory activity was evaluated by Mouse Cytokine/Chemokine Magnetic Bead Panel 96-well plate assay. Among the 15 different phenolics found in CPS extracts obtained at 120 or 150 minutes of maceration with 2500 UI/L at 30ºC or 45 ºC in a 1:15 (w:v) proportion, the most abundant was vanillic acid (7.97–12.66 µg/g). The extract obtained at 30ºC and 120 minutes, showed similar effects than the observed for synthetic anti-inflammatory drugs indomethacin and dexamethasone and capsaicin standard. Beyond capsaicin, salicylic, protocatechuic and trans -cinnamic acids as well as vanillin in CPS extracts were correlated with the anti-inflammatory effect. On the other hand, capsaicin and chlorogenic acid contents were potential immunostimulants whose concentration varied depending on the cellulase treatment time." @default.
- W4289443375 created "2022-08-02" @default.
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- W4289443375 date "2022-08-02" @default.
- W4289443375 modified "2023-10-18" @default.
- W4289443375 title "In vitro evaluation of anti-inflammatory activity of “Habanero” chili pepper (Capsicum chinense) seeds extracts pretreated with cellulase" @default.
- W4289443375 doi "https://doi.org/10.21203/rs.3.rs-1871277/v1" @default.
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