Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289443847> ?p ?o ?g. }
- W4289443847 endingPage "116073" @default.
- W4289443847 startingPage "116073" @default.
- W4289443847 abstract "Skin wound infections can be considered one of the most common causes of death in burned patients. The raising reports of multidrug resistant microorganisms reveals a complicated condition for the treatment of burn wound injuries, establishing urgency in the development of novel antimicrobial agents. Considering this scenario, the present work describes the synthesis, antibacterial and antifungal activities of a sulfadoxine-salicylaldehyde Schiff base (SFX-SL), and of its novel dimeric silver(I) complex (AgSFX-SL). Elemental analysis indicated a 1:1 metal:ligand molar composition for the AgSFX-SL complex, with the minimum formula AgC19H17N4O5S. Mass spectrometric (HRMS) data reveal the existence of dimeric species of the complex in solution. Infrared (FT-IR) and nuclear magnetic resonance (NMR) spectroscopic studies suggest coordination of the Schiff base to silver(I) by the nitrogen and oxygen atoms of the sulfonamide group. The structure of the SFX-SL Schiff base was determined by single crystal X-ray diffraction. Molecular modeling confirms the proposition of a dimeric structure for the AgSFX-SL complex as early indicated by mass spectrometric data. The AgSFX-SL complex showed an effective antimicrobial activity over pathogens including Gram-positive Staphylococcus aureus (multidrug resistant), S. epidermidis, Cutibacterium acnes, and Gram-negative Pseudomonas aeruginosa and Burkholderia cepacia, with minimum inhibitory concentration (MIC) values in the range 12.0–48.0 µmol·L−1. Additionally, the AgSFX-SL complex was active against Candida albicans with a MIC value of 2.8 µmol·L−1. Electrophoresis assays showed that the AgSFX-SL complex does not interact with protein models lysozyme and bovine serum albumin (BSA)." @default.
- W4289443847 created "2022-08-02" @default.
- W4289443847 creator A5014116814 @default.
- W4289443847 creator A5037890097 @default.
- W4289443847 creator A5060680588 @default.
- W4289443847 creator A5061185993 @default.
- W4289443847 creator A5065464354 @default.
- W4289443847 creator A5072649917 @default.
- W4289443847 creator A5087193186 @default.
- W4289443847 creator A5088627509 @default.
- W4289443847 creator A5090874214 @default.
- W4289443847 date "2022-10-01" @default.
- W4289443847 modified "2023-10-02" @default.
- W4289443847 title "Antibacterial and antifungal activities in vitro of a novel silver(I) complex with sulfadoxine-salicylaldehyde Schiff base" @default.
- W4289443847 cites W101691944 @default.
- W4289443847 cites W1854797600 @default.
- W4289443847 cites W1965173894 @default.
- W4289443847 cites W1967530006 @default.
- W4289443847 cites W1969360633 @default.
- W4289443847 cites W1972315532 @default.
- W4289443847 cites W1979368277 @default.
- W4289443847 cites W2011906070 @default.
- W4289443847 cites W2015185525 @default.
- W4289443847 cites W2037930032 @default.
- W4289443847 cites W2044202126 @default.
- W4289443847 cites W2046412723 @default.
- W4289443847 cites W2051981596 @default.
- W4289443847 cites W2054209009 @default.
- W4289443847 cites W2057351188 @default.
- W4289443847 cites W2058363175 @default.
- W4289443847 cites W2059205366 @default.
- W4289443847 cites W2068617439 @default.
- W4289443847 cites W2075033528 @default.
- W4289443847 cites W2094083551 @default.
- W4289443847 cites W2099198335 @default.
- W4289443847 cites W2112850441 @default.
- W4289443847 cites W2121452230 @default.
- W4289443847 cites W2123918839 @default.
- W4289443847 cites W2132454074 @default.
- W4289443847 cites W2152296132 @default.
- W4289443847 cites W2319902168 @default.
- W4289443847 cites W2325362932 @default.
- W4289443847 cites W2410538093 @default.
- W4289443847 cites W2474326167 @default.
- W4289443847 cites W2479427670 @default.
- W4289443847 cites W2499727915 @default.
- W4289443847 cites W2531661680 @default.
- W4289443847 cites W2733466519 @default.
- W4289443847 cites W2754510205 @default.
- W4289443847 cites W2756243705 @default.
- W4289443847 cites W2798187500 @default.
- W4289443847 cites W2884210144 @default.
- W4289443847 cites W2899053627 @default.
- W4289443847 cites W2910724150 @default.
- W4289443847 cites W2913434007 @default.
- W4289443847 cites W2969768352 @default.
- W4289443847 cites W2970455373 @default.
- W4289443847 cites W3005921653 @default.
- W4289443847 cites W3007079971 @default.
- W4289443847 cites W3015548681 @default.
- W4289443847 cites W3027647493 @default.
- W4289443847 cites W3030560813 @default.
- W4289443847 cites W3088105697 @default.
- W4289443847 cites W3103422819 @default.
- W4289443847 cites W3119276917 @default.
- W4289443847 cites W3128421419 @default.
- W4289443847 cites W3129498646 @default.
- W4289443847 cites W3161185112 @default.
- W4289443847 cites W3186051454 @default.
- W4289443847 cites W3190366204 @default.
- W4289443847 cites W4239635201 @default.
- W4289443847 doi "https://doi.org/10.1016/j.poly.2022.116073" @default.
- W4289443847 hasPublicationYear "2022" @default.
- W4289443847 type Work @default.
- W4289443847 citedByCount "6" @default.
- W4289443847 countsByYear W42894438472022 @default.
- W4289443847 countsByYear W42894438472023 @default.
- W4289443847 crossrefType "journal-article" @default.
- W4289443847 hasAuthorship W4289443847A5014116814 @default.
- W4289443847 hasAuthorship W4289443847A5037890097 @default.
- W4289443847 hasAuthorship W4289443847A5060680588 @default.
- W4289443847 hasAuthorship W4289443847A5061185993 @default.
- W4289443847 hasAuthorship W4289443847A5065464354 @default.
- W4289443847 hasAuthorship W4289443847A5072649917 @default.
- W4289443847 hasAuthorship W4289443847A5087193186 @default.
- W4289443847 hasAuthorship W4289443847A5088627509 @default.
- W4289443847 hasAuthorship W4289443847A5090874214 @default.
- W4289443847 hasConcept C116569031 @default.
- W4289443847 hasConcept C170493617 @default.
- W4289443847 hasConcept C176947019 @default.
- W4289443847 hasConcept C178790620 @default.
- W4289443847 hasConcept C185592680 @default.
- W4289443847 hasConcept C2776428424 @default.
- W4289443847 hasConcept C2779256853 @default.
- W4289443847 hasConcept C2780104969 @default.
- W4289443847 hasConcept C4937899 @default.
- W4289443847 hasConcept C523546767 @default.
- W4289443847 hasConcept C54355233 @default.