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• W4289518172 endingPage "e0271697" @default.
• W4289518172 startingPage "e0271697" @default.
• W4289518172 abstract "Simultaneous imaging of l -dihydroxyphenylalanine ( l -DOPA), dopamine (DA) and norepinephrine (NE) in the catecholamine metabolic pathway is particularly useful because l -DOPA is a neurophysiologically important metabolic intermediate. In this study, we found that 2,4,6-trimethylpyrillium tetrafluoroborate (TMPy) can selectively and efficiently react with target catecholamine molecules. Specifically, simultaneous visualization of DA and NE as metabolites of l -DOPA with high steric hinderance was achieved by derivatized-imaging mass spectrometry (IMS). Interestingly, l -DOPA showed strong localization in the brainstem, in contrast to the pattern of DA and NE, which co-localized with tyrosine hydroxylase (TH). In addition, to identify whether the detected molecules were endogenous or exogenous l -DOPA, mice were injected with l -DOPA deuterated in three positions (D 3 - l -DOPA), which was identifiable by a mass shift of 3Da. TMPy-labeled l -DOPA, DA and NE were detected at m/z 302.1, 258.1 and 274.1, while their D 3 versions were detected at 305.0, 261.1 and 277.1 in mouse brain, respectively. l -DOPA and D 3 - l -DOPA were localized in the BS. DA and NE, and D 3 -DA and D 3 -NE, all of which are metabolites of L-DOPA and D 3 - l -DOPA, were localized in the striatum (STR) and locus coeruleus (LC). These findings suggest a mechanism in the brainstem that allows l -DOPA to accumulate without being metabolized to monoamines downstream of the metabolic pathway." @default.
• W4289518172 created "2022-08-03" @default.
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• W4289518172 date "2022-08-02" @default.
• W4289518172 modified "2023-10-14" @default.
• W4289518172 title "Pyrylium based derivatization imaging mass spectrometer revealed the localization of L-DOPA" @default.
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• W4289518172 doi "https://doi.org/10.1371/journal.pone.0271697" @default.
• W4289518172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35917331" @default.
• W4289518172 hasPublicationYear "2022" @default.
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