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- W4289519605 abstract "Low-density lipoprotein (LDL) apheresis is a treatment option for patients with unhealed chronic limb-threatening ischemia (CLTI) after revascularization. The newly developed AS-25 is a direct hemoperfusion-type apheresis device that differs from conventional LDL apheresis therapy and is designed to specifically adsorb both LDL-C and fibrinogen. We evaluate the efficacy and safety of AS-25.This study included 61 patients whose ulcers failed to heal after revascularization or were ineligible for revascularization. Of these, 50 were undergoing hemodialysis. The primary endpoint was the healing rate of a target lesion of interest (ulcer), using historical data as control.The ulcer healing rate of 45.9% was significantly higher than the historical data. No significant safety concerns were observed.AS-25 was effective in healing ulcers and preventing major amputation even in CLTI refractory patients on hemodialysis, thus showing potential clinical applicability and high significance.UMIN study ID UMIN000020336." @default.
- W4289519605 created "2022-08-03" @default.
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- W4289519605 date "2022-08-16" @default.
- W4289519605 modified "2023-10-18" @default.
- W4289519605 title "A novel low‐density lipoprotein/fibrinogen apheresis method for chronic limb‐threatening ischemia in patients with poor options for revascularization: A multicenter, single‐arm clinical trial" @default.
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- W4289519605 doi "https://doi.org/10.1111/1744-9987.13915" @default.
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