Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289519880> ?p ?o ?g. }
- W4289519880 endingPage "1869" @default.
- W4289519880 startingPage "1869" @default.
- W4289519880 abstract "Cerebrospinal fluid (CSF) and serum biomarkers are critical for clinical decision making in neurological diseases. In cerebral small vessel disease (CSVD), white matter hyperintensities (WMH) are an important neuroimaging biomarker, but more blood-based biomarkers capturing different aspects of CSVD pathology are needed. In 42 sporadic CSVD patients, we prospectively analysed WMH on magnetic resonance imaging (MRI) and the biomarkers neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), chitinase3-like protein 1 (CHI3L1), Tau and Aβ1-42 in CSF and NfL and GFAP in serum. GFAP and CHI3L1 expression was studied in post-mortem brain tissue in additional cases. CSVD cases with higher serum NfL and GFAP levels had a higher modified Rankin Scale (mRS) and NIHSS score and lower CSF Aβ1-42 levels, whereas the CSF NfL and CHI3L1 levels were positively correlated with the WMH load. Moreover, the serum GFAP levels significantly correlated with the neurocognitive functions. Pathological analyses in CSVD revealed a high density of GFAP-immunoreactive fibrillary astrocytic processes in the periventricular white matter and clusters of CHI3L1-immunoreactive astrocytes in the basal ganglia and thalamus. Thus, besides NfL, serum GFAP is a highly promising fluid biomarker of sporadic CSVD, because it does not only correlate with the clinical severity but also correlates with the cognitive function in patients." @default.
- W4289519880 created "2022-08-03" @default.
- W4289519880 creator A5008484351 @default.
- W4289519880 creator A5010067098 @default.
- W4289519880 creator A5021936961 @default.
- W4289519880 creator A5030781289 @default.
- W4289519880 creator A5037398644 @default.
- W4289519880 creator A5059480753 @default.
- W4289519880 creator A5071308068 @default.
- W4289519880 creator A5078995974 @default.
- W4289519880 creator A5083100987 @default.
- W4289519880 creator A5084076876 @default.
- W4289519880 creator A5090410744 @default.
- W4289519880 date "2022-08-02" @default.
- W4289519880 modified "2023-10-05" @default.
- W4289519880 title "Association of Serum GFAP with Functional and Neurocognitive Outcome in Sporadic Small Vessel Disease" @default.
- W4289519880 cites W1567524252 @default.
- W4289519880 cites W1848958182 @default.
- W4289519880 cites W1969661146 @default.
- W4289519880 cites W1975526438 @default.
- W4289519880 cites W1977206425 @default.
- W4289519880 cites W1978316308 @default.
- W4289519880 cites W1994723621 @default.
- W4289519880 cites W1995507499 @default.
- W4289519880 cites W2023938799 @default.
- W4289519880 cites W2025774809 @default.
- W4289519880 cites W2026070709 @default.
- W4289519880 cites W2034822458 @default.
- W4289519880 cites W2038145343 @default.
- W4289519880 cites W2052742260 @default.
- W4289519880 cites W2057911246 @default.
- W4289519880 cites W2080504768 @default.
- W4289519880 cites W2089435027 @default.
- W4289519880 cites W2104901197 @default.
- W4289519880 cites W2122024315 @default.
- W4289519880 cites W2122477279 @default.
- W4289519880 cites W2130641904 @default.
- W4289519880 cites W2140621953 @default.
- W4289519880 cites W2144212512 @default.
- W4289519880 cites W2148651129 @default.
- W4289519880 cites W2148907640 @default.
- W4289519880 cites W2151384687 @default.
- W4289519880 cites W2157032372 @default.
- W4289519880 cites W2161104189 @default.
- W4289519880 cites W2318875567 @default.
- W4289519880 cites W2338573220 @default.
- W4289519880 cites W2517883070 @default.
- W4289519880 cites W2600914407 @default.
- W4289519880 cites W2765168396 @default.
- W4289519880 cites W2804435536 @default.
- W4289519880 cites W2805512903 @default.
- W4289519880 cites W2883678860 @default.
- W4289519880 cites W2889223700 @default.
- W4289519880 cites W2889825783 @default.
- W4289519880 cites W2893296071 @default.
- W4289519880 cites W2894413318 @default.
- W4289519880 cites W2894776090 @default.
- W4289519880 cites W2901114341 @default.
- W4289519880 cites W2906455140 @default.
- W4289519880 cites W2907478403 @default.
- W4289519880 cites W2909749211 @default.
- W4289519880 cites W2910313823 @default.
- W4289519880 cites W2910535142 @default.
- W4289519880 cites W2925266449 @default.
- W4289519880 cites W2946066695 @default.
- W4289519880 cites W2946129327 @default.
- W4289519880 cites W2970676275 @default.
- W4289519880 cites W2981690912 @default.
- W4289519880 cites W2997970081 @default.
- W4289519880 cites W3011163714 @default.
- W4289519880 cites W3019122005 @default.
- W4289519880 cites W3028945888 @default.
- W4289519880 cites W3089365441 @default.
- W4289519880 cites W3139119642 @default.
- W4289519880 doi "https://doi.org/10.3390/biomedicines10081869" @default.
- W4289519880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36009416" @default.
- W4289519880 hasPublicationYear "2022" @default.
- W4289519880 type Work @default.
- W4289519880 citedByCount "3" @default.
- W4289519880 countsByYear W42895198802023 @default.
- W4289519880 crossrefType "journal-article" @default.
- W4289519880 hasAuthorship W4289519880A5008484351 @default.
- W4289519880 hasAuthorship W4289519880A5010067098 @default.
- W4289519880 hasAuthorship W4289519880A5021936961 @default.
- W4289519880 hasAuthorship W4289519880A5030781289 @default.
- W4289519880 hasAuthorship W4289519880A5037398644 @default.
- W4289519880 hasAuthorship W4289519880A5059480753 @default.
- W4289519880 hasAuthorship W4289519880A5071308068 @default.
- W4289519880 hasAuthorship W4289519880A5078995974 @default.
- W4289519880 hasAuthorship W4289519880A5083100987 @default.
- W4289519880 hasAuthorship W4289519880A5084076876 @default.
- W4289519880 hasAuthorship W4289519880A5090410744 @default.
- W4289519880 hasBestOaLocation W42895198801 @default.
- W4289519880 hasConcept C118552586 @default.
- W4289519880 hasConcept C126322002 @default.
- W4289519880 hasConcept C126838900 @default.
- W4289519880 hasConcept C142724271 @default.
- W4289519880 hasConcept C143409427 @default.