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• W4289520005 abstract "Abstract Objective The role of HIV exposure in determining growth among HIV‐uninfected children is debated. We determined whether intrauterine HIV exposure influences linear growth in a cohort of Ethiopian children followed up to 18 months of age in public health facilities in Adama city, Ethiopia. Methods Participants were offspring of pregnant women enrolled in a prospective cohort study that included screening for HIV infection during antenatal care. Growth patterns of HIV‐exposed and uninfected (HEU) and HIV‐unexposed (HU) children were compared up to 18 months of age, with length‐for‐age z‐score (LAZ) and proportion with stunting as primary outcomes. Multivariable linear and logistic regression models were constructed to investigate the associations between HIV exposure and linear growth, controlling for socio‐demographic factors and breastfeeding status. Results Of 1705 included infants (164 HEU), 1276 remained in follow‐up at 18 months. Among HIV‐positive mothers, 132 (80.5%) were receiving antiretroviral therapy at enrolment. At the 18‐month visit, mean LAZ was −1.08 among HEU children and −0.74 among HU children ( p = 0.052). Proportions of HEU and HU children with stunting at the 18‐month visit were 27.8% and 18.7%, respectively ( p = 0.010). In multivariable models, HIV exposure was associated with lower LAZ at all follow‐up visits, and with stunting at the 18‐month visit (adjusted odds ratio 2.29, 95% confidence interval 1.40–3.71). HIV exposure was not associated with weight‐related growth outcomes. Conclusions HEU children in Ethiopia had inferior linear growth compared with HU children, implying that intrauterine HIV exposure impacts early childhood growth in this setting." @default.
• W4289520005 created "2022-08-03" @default.
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• W4289520005 date "2022-08-17" @default.
• W4289520005 modified "2023-09-26" @default.
• W4289520005 title "Intrauterine <scp>HIV</scp> exposure is associated with linear growth restriction among Ethiopian children in the first 18 months of life" @default.
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• W4289520005 doi "https://doi.org/10.1111/tmi.13805" @default.
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