FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289522531> ?p ?o ?g. }

• W4289522531 endingPage "1176" @default.
• W4289522531 startingPage "1167" @default.
• W4289522531 abstract "Hair loss, including alopecia, is a common dermatological issue worldwide. At present, the application of fractional carbon dioxide (CO2 ) laser in the treatment of alopecia has been documented; however, the results vary between reports. These varying results may be due to the limited knowledge of cellular action in laser-irradiated skin. The objective of this study was to investigate the molecular and cellular mechanisms of laser treatment under effective conditions for hair cycle initiation.A fractional CO2 laser was applied and optimized to initiate the hair cycle in a mouse model of alopecia. Several cellular markers were analyzed in the irradiated skin using immunofluorescence staining. Cellular populations and their comprehensive gene expression were analyzed using single-cell RNA sequencing and bioinformatics.The effective irradiation condition for initiating the hair cycle was found to be 15 mJ energy/spot, which generates approximately 500 μm depth columns, but does not penetrate the dermis, only reaching approximately 1 spot/mm2 . The proportion of macrophage clusters significantly increased upon irradiation, whereas the proportion of fibroblast clusters decreased. The macrophages strongly expressed C-C chemokine receptor type 2 (Ccr2), which is known to be a key signal for injury-induced hair growth.We found that fractional CO2 laser irradiation recruited Ccr2 positive macrophages, and induced hair regrowth in a mouse alopecia model. These findings may contribute to the development of stable and effective fractional laser irradiation conditions for human alopecia treatment." @default.
• W4289522531 created "2022-08-03" @default.
• W4289522531 creator A5002559044 @default.
• W4289522531 creator A5013073310 @default.
• W4289522531 creator A5015580452 @default.
• W4289522531 creator A5031178248 @default.
• W4289522531 creator A5032090126 @default.
• W4289522531 creator A5048878277 @default.
• W4289522531 creator A5054902046 @default.
• W4289522531 creator A5056394553 @default.
• W4289522531 creator A5062019634 @default.
• W4289522531 creator A5063172612 @default.
• W4289522531 creator A5072326172 @default.
• W4289522531 date "2022-08-02" @default.
• W4289522531 modified "2023-09-26" @default.
• W4289522531 title "Single‐cell transcriptome analysis of fractional CO ₂ laser efficiency in treating a mouse model of alopecia" @default.
• W4289522531 cites W1556466499 @default.
• W4289522531 cites W1598939437 @default.
• W4289522531 cites W1955364818 @default.
• W4289522531 cites W1964872204 @default.
• W4289522531 cites W1981411479 @default.
• W4289522531 cites W1984065166 @default.
• W4289522531 cites W1986346289 @default.
• W4289522531 cites W2002417121 @default.
• W4289522531 cites W2015743573 @default.
• W4289522531 cites W2023078673 @default.
• W4289522531 cites W2028517772 @default.
• W4289522531 cites W2059139443 @default.
• W4289522531 cites W2086381423 @default.
• W4289522531 cites W2101399701 @default.
• W4289522531 cites W2116471128 @default.
• W4289522531 cites W2134718981 @default.
• W4289522531 cites W2140027591 @default.
• W4289522531 cites W2150083629 @default.
• W4289522531 cites W2169456326 @default.
• W4289522531 cites W2344927296 @default.
• W4289522531 cites W2443879772 @default.
• W4289522531 cites W2514454453 @default.
• W4289522531 cites W2603911205 @default.
• W4289522531 cites W2614156854 @default.
• W4289522531 cites W2616137790 @default.
• W4289522531 cites W2745782690 @default.
• W4289522531 cites W2794480084 @default.
• W4289522531 cites W2800392236 @default.
• W4289522531 cites W2803335705 @default.
• W4289522531 cites W2913209689 @default.
• W4289522531 cites W2924123122 @default.
• W4289522531 cites W2925862067 @default.
• W4289522531 cites W2926178617 @default.
• W4289522531 cites W2951435549 @default.
• W4289522531 cites W2998928493 @default.
• W4289522531 cites W3005941050 @default.
• W4289522531 cites W3022261812 @default.
• W4289522531 cites W3028730642 @default.
• W4289522531 cites W3114920225 @default.
• W4289522531 cites W3155386417 @default.
• W4289522531 cites W3156774813 @default.
• W4289522531 cites W3172816093 @default.
• W4289522531 cites W3212380991 @default.
• W4289522531 cites W3217191701 @default.
• W4289522531 cites W658050074 @default.
• W4289522531 doi "https://doi.org/10.1002/lsm.23590" @default.
• W4289522531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35916125" @default.
• W4289522531 hasPublicationYear "2022" @default.
• W4289522531 type Work @default.
• W4289522531 citedByCount "1" @default.
• W4289522531 countsByYear W42895225312023 @default.
• W4289522531 crossrefType "journal-article" @default.
• W4289522531 hasAuthorship W4289522531A5002559044 @default.
• W4289522531 hasAuthorship W4289522531A5013073310 @default.
• W4289522531 hasAuthorship W4289522531A5015580452 @default.
• W4289522531 hasAuthorship W4289522531A5031178248 @default.
• W4289522531 hasAuthorship W4289522531A5032090126 @default.
• W4289522531 hasAuthorship W4289522531A5048878277 @default.
• W4289522531 hasAuthorship W4289522531A5054902046 @default.
• W4289522531 hasAuthorship W4289522531A5056394553 @default.
• W4289522531 hasAuthorship W4289522531A5062019634 @default.
• W4289522531 hasAuthorship W4289522531A5063172612 @default.
• W4289522531 hasAuthorship W4289522531A5072326172 @default.
• W4289522531 hasConcept C104317684 @default.
• W4289522531 hasConcept C105702510 @default.
• W4289522531 hasConcept C111337013 @default.
• W4289522531 hasConcept C121332964 @default.
• W4289522531 hasConcept C142724271 @default.
• W4289522531 hasConcept C1491633281 @default.
• W4289522531 hasConcept C150194340 @default.
• W4289522531 hasConcept C153911025 @default.
• W4289522531 hasConcept C162317418 @default.
• W4289522531 hasConcept C185544564 @default.
• W4289522531 hasConcept C185592680 @default.
• W4289522531 hasConcept C2776458125 @default.
• W4289522531 hasConcept C2777624698 @default.
• W4289522531 hasConcept C2780381497 @default.
• W4289522531 hasConcept C29537977 @default.
• W4289522531 hasConcept C502942594 @default.
• W4289522531 hasConcept C54355233 @default.
• W4289522531 hasConcept C55493867 @default.
• W4289522531 hasConcept C71924100 @default.

• next