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• W4289522776 endingPage "4923" @default.
• W4289522776 startingPage "4923" @default.
• W4289522776 abstract "Nicotinamide nucleotide transhydrogenase (NNT) is involved in decreasing melanogenesis through tyrosinase degradation induced by cellular redox changes. Nicotinamide is a component of coenzymes, such as NAD+, NADH, NADP+, and NADPH, and its levels are modulated by NNT. Vitamin C and polydeoxyribonucleotide (PDRN) are also known to decrease skin pigmentation. We evaluated whether a mixture of nicotinamide, vitamin C, and PDRN (NVP-mix) decreased melanogenesis by modulating mitochondrial oxidative stress and NNT expression in UV-B-irradiated animals and in an in vitro model of melanocytes treated with conditioned media (CM) from UV-B-irradiated keratinocytes. The expression of NNT, GSH/GSSG, and NADPH/NADP+ in UV-B-irradiated animal skin was significantly decreased by UV-B radiation but increased by NVP-mix treatment. The expression of NNT, GSH/GSSG, and NADPH/NADP+ ratios decreased in melanocytes after CM treatment, although they increased after NVP-mix administration. In NNT-silenced melanocytes, the GSH/GSSG and NADPH/NADP+ ratios were further decreased by CM compared with normal melanocytes. NVP-mix decreased melanogenesis signals, such as MC1R, MITF, TYRP1, and TYRP2, and decreased melanosome transfer-related signals, such as RAB32 and RAB27A, in UV-B-irradiated animal skin. NVP-mix also decreased MC1R, MITF, TYRP1, TYRP2, RAB32, and RAB27A in melanocytes treated with CM from UV-irradiated keratinocytes. The expression of MC1R and MITF in melanocytes after CM treatment was unchanged by NNT silencing. However, the expression of TYRP1, TYRP2, RAB32, and RAB27A increased in NNT-silenced melanocytes after CM treatment. NVP-mix also decreased tyrosinase activity and melanin content in UV-B-irradiated animal skin and CM-treated melanocytes. In conclusion, NVP-mix decreased mitochondrial oxidative stress by increasing NNT expression and decreased melanogenesis by decreasing MC1R/MITF, tyrosinase, TYRP1, and TYRP2." @default.
• W4289522776 created "2022-08-03" @default.
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• W4289522776 date "2022-08-02" @default.
• W4289522776 modified "2023-09-30" @default.
• W4289522776 title "The Combination of Niacinamide, Vitamin C, and PDRN Mitigates Melanogenesis by Modulating Nicotinamide Nucleotide Transhydrogenase" @default.
• W4289522776 cites W1963091570 @default.
• W4289522776 cites W1966454263 @default.
• W4289522776 cites W1968873996 @default.
• W4289522776 cites W1970554352 @default.
• W4289522776 cites W1974607230 @default.
• W4289522776 cites W1975966519 @default.
• W4289522776 cites W1980211575 @default.
• W4289522776 cites W1988024403 @default.
• W4289522776 cites W1988908127 @default.
• W4289522776 cites W1989313196 @default.
• W4289522776 cites W1993773159 @default.
• W4289522776 cites W2006597186 @default.
• W4289522776 cites W2010816819 @default.
• W4289522776 cites W2015153883 @default.
• W4289522776 cites W2022552518 @default.
• W4289522776 cites W2024103019 @default.
• W4289522776 cites W2028273608 @default.
• W4289522776 cites W2030352819 @default.
• W4289522776 cites W2031951021 @default.
• W4289522776 cites W2032442890 @default.
• W4289522776 cites W203762245 @default.
• W4289522776 cites W2041128667 @default.
• W4289522776 cites W2045202298 @default.
• W4289522776 cites W2047037182 @default.
• W4289522776 cites W2049546127 @default.
• W4289522776 cites W2050092447 @default.
• W4289522776 cites W2054364004 @default.
• W4289522776 cites W2054848055 @default.
• W4289522776 cites W2057948101 @default.
• W4289522776 cites W2059861459 @default.
• W4289522776 cites W2064316112 @default.
• W4289522776 cites W2069628967 @default.
• W4289522776 cites W2071805371 @default.
• W4289522776 cites W2075743293 @default.
• W4289522776 cites W2075868440 @default.
• W4289522776 cites W2076121443 @default.
• W4289522776 cites W2077986468 @default.
• W4289522776 cites W2087683794 @default.
• W4289522776 cites W2092129054 @default.
• W4289522776 cites W2095289520 @default.
• W4289522776 cites W2108175127 @default.
• W4289522776 cites W2109412819 @default.
• W4289522776 cites W2115052984 @default.
• W4289522776 cites W2133095097 @default.
• W4289522776 cites W2146940742 @default.
• W4289522776 cites W2149250648 @default.
• W4289522776 cites W2156931352 @default.
• W4289522776 cites W2159983436 @default.
• W4289522776 cites W2165973127 @default.
• W4289522776 cites W2471321097 @default.
• W4289522776 cites W2481948442 @default.
• W4289522776 cites W2507671702 @default.
• W4289522776 cites W2608482373 @default.
• W4289522776 cites W2622821813 @default.
• W4289522776 cites W2722324655 @default.
• W4289522776 cites W2736417759 @default.
• W4289522776 cites W2778909798 @default.
• W4289522776 cites W2800217088 @default.
• W4289522776 cites W2804916341 @default.
• W4289522776 cites W2887333955 @default.
• W4289522776 cites W2899970640 @default.
• W4289522776 cites W2901800475 @default.
• W4289522776 cites W2942338743 @default.
• W4289522776 cites W2962867828 @default.
• W4289522776 cites W2978861355 @default.
• W4289522776 cites W3021972214 @default.
• W4289522776 cites W3115044972 @default.
• W4289522776 cites W3164729721 @default.
• W4289522776 cites W3182612754 @default.
• W4289522776 cites W4212831473 @default.
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• W4289522776 doi "https://doi.org/10.3390/molecules27154923" @default.
• W4289522776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35956878" @default.
• W4289522776 hasPublicationYear "2022" @default.
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