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• W4289523786 abstract "This paper explores the assessment value of pathological condition of serum adiponectin (APN) and amylin in primary osteoporosis (POP) and their correlation with bone metabolism indexes.From January 2019 to June 2021, 79 cases of POP patients were selected as the research objects. A test of the patients' bone density was conducted, and clinical grading of POP was via T value (normal, mild, moderate, severe). The analysis of the assessment value of pathological condition of serum APN and amylin for POP and their association with bone metabolism indexes in patients was performed.APN and amylin in patients were declined with POP's aggravation. APN of 5.15 μg/mL or less and amylin of 15.38 pmol/L or less were risk factors influencing the aggravation of pathological condition of POP (P< 0 .0 5). The area under the curve (AUC) of combined detection of APN and amylin to assess the severity of POP was elevated vs. alone test of amylin (P< 0.05). 25-hydroxyvitamin D (25-(OH) D) and total type 1 procollagen amino-terminal propeptide (t-PINP) in patients were descended with the aggravation of pathological condition of osteoporosis (P < 0.05). At the same time, no distinct differences were presented in the three groups of type I collagen hydroxyl terminal peptide b degradation product (β-CTX) and N-terminal osteocalcin (N-MID) (P> 0.05). APN, amylin, 25-(OH)D, β-CTX, and t-PINP were negatively linked with POP clinical grade (P< 0.05). APN and amylin were associated with 25-(OH) D, β-CTX, t-PINP (P< 0.05), and APN and amylin were not linked with N-MID (P> 0.05).Serum APN and amylin are provided with evaluation values for the severity of POP and are associated with bone metabolism in patients.Ovaj rad ispituje značaj serumskog adiponektina i amilina kod procene patološkog stanja u primarne osteoporoze i analizu korelacije sa indeksima koštanog metabolizma.Kao predmet istraživanja, od januara 2019. do juna 2021. godine je odabrano 79 slučajeva pacijenata sa POP-om. Sproveden je test gustine kostiju pacijenata a klinička procena POP je urađena preko T vrednosti (normalna, blaga, umerena, teška). Urađena je analiza značaja procene patološkog stanja putem serumskog APN i amilina na POP i njihove povezanosti sa indeksima koštanog metabolizma kod pacijenata.APN i amilin kod pacijenata su smanjeni sa pogoršanjem POP-a. APN od 5,15 mg/mL ili manje i amilin od 15,38 pmol/L ili manje su bili faktori rizika koji utiču na pogoršanje patološkog stanja POP (P< 0,05). Površina ispod krive (AUC) kombinovane detekcije APN-a i amilina za procenu ozbiljnosti POP-a je bila povišena u odnosu na sam test amilina (P< 0,05). 25-hidroksivitamin D (25-(OH) D) i ukupni amino-terminalni propeptid prokolagena tipa 1 (t-PINP) kod pacijenata su sniženi sa pogoršanjem patološkog stanja osteoporoze (P< 0,05). U isto vreme, nisu predstavljene jasne razlike u tri grupe proizvoda b degradacije hidroksil terminalnog peptida kolagena tipa I (b-CTKS) i N-terminalnog osteokalcina (N-MID) (P> 0,05). APN, amilin, 25-(OH)D, b-CTKS i t-PINP su bili negativno povezani sa kliničkom ocenom POP (P< 0,05). APN i amilin su bili povezani sa 25-(OH) D, b-CTKS, t-PINP (P< 0,05), dok APN i amilin nisu bili povezani sa NMID (P> 0,05).APN i amilin u serumu su od značaja za procenu težine POP i povezani su sa metabolizmom kostiju kod pacijenata." @default.
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• W4289523786 date "2023-01-01" @default.
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• W4289523786 title "The assessment value of pathological condition of serum adiponectin and amylin in primary osteoporosis and its correlation analysis with bone metabolism indexes" @default.
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• W4289523786 doi "https://doi.org/10.5937/jomb0-35877" @default.
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