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- W4289528242 abstract "Activatable fluorophores with emission beyond 1000 nm have the potential to enable high contrast imaging in complex in vivo settings. However, there are few scaffolds that can be applied to this challenge. Here we detail the synthesis and evaluation of benzo[c,d]indole-substituted norcyanines that enable pH responsive fluorescence imaging in the long wavelength (>1150 nm) range. A key component of our molecular design is the installation of a hydrophilic substituted quaternary amine in the central dihydropyridine ring system. A compound with a C4'-phenyl substituent, but not the C4'-protio homologue, exhibits absorbance maxima of 740 nm and 1130 nm in basic and acidic media, respectively, with evidence of J-aggregate-like properties. These two distinct absorbances enabled ratiometric imaging of probe internalization in a tumor model. Overall, these studies provide a new class of activatable long-wavelength responsive fluorophores with promising photophysical properties." @default.
- W4289528242 created "2022-08-03" @default.
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- W4289528242 date "2022-12-01" @default.
- W4289528242 modified "2023-09-23" @default.
- W4289528242 title "Modified norcyanines enable ratiometric pH imaging beyond 1000 nm" @default.
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- W4289528242 doi "https://doi.org/10.1016/j.bios.2022.114610" @default.
- W4289528242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36137483" @default.
- W4289528242 hasPublicationYear "2022" @default.
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