Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289528305> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4289528305 abstract "Guidelines for the management of gastroesophageal junction (GEJ) adenocarcinoma recommend esophagectomy as the preferred surgical treatment. Gastrectomy has been proposed as an equivalent procedure. This study aims to compare the oncologic outcomes of these operations. The National Cancer Database was queried for patients with clinical T1N0M0 (all sizes) and T2N0M0 (≤2cm) GEJ adenocarcinoma from 2004-2017. Patients treated with surgery-only were included and were stratified by surgical treatment. Propensity-score matching (PSM) was used to create a balanced cohort. Multivariable logistic regression was performed to evaluate for factors predictive of treatment. Kaplan-Meier (KM) and Cox proportional hazards models were used to compare overall survival (OS). 2,446 patients were identified. 75.1% received esophagectomy, while 24.9% were treated with gastrectomy. Patients at high volume facilities were more likely to undergo esophagectomy (OR 1.750, P < 0.001). Factors associated with lower likelihood of undergoing esophagectomy included age ≥75 years (OR 0.588, P = 0.001), female sex (OR 0.706, P = 0.003), and non-White race (OR 0.430, P < 0.001), compared to age ≤50 years, male, and White race, respectively. In the unmatched cohort, gastrectomy was associated with a higher rate of positive margins (4.1% vs 2.3%, P = 0.022). PSM yielded 591 pairs. In the matched cohort, patients treated with esophagectomy had improved 5-year OS compared to gastrectomy (70.6% vs 66.5%, P = 0.030). Multivariable analysis showed improved OS in patients treated with esophagectomy compared to gastrectomy (HR 0.767, P = 0.010). Esophagectomy is associatedwith improved survival and a lower incidence of positive margins in patients with early-stage GEJ adenocarcinoma when compared to gastrectomy." @default.
- W4289528305 created "2022-08-03" @default.
- W4289528305 creator A5023657268 @default.
- W4289528305 creator A5027848476 @default.
- W4289528305 creator A5029035012 @default.
- W4289528305 creator A5045712741 @default.
- W4289528305 creator A5049001836 @default.
- W4289528305 creator A5071516432 @default.
- W4289528305 date "2022-08-01" @default.
- W4289528305 modified "2023-10-14" @default.
- W4289528305 title "Esophagectomy vs Gastrectomy for Early Stage Adenocarcinoma of the Gastroesophageal Junction: What is the Optimal Oncologic Surgical Treatment?" @default.
- W4289528305 cites W1865426939 @default.
- W4289528305 cites W1965012862 @default.
- W4289528305 cites W1965209405 @default.
- W4289528305 cites W1967128680 @default.
- W4289528305 cites W1974167807 @default.
- W4289528305 cites W2004079062 @default.
- W4289528305 cites W2028352052 @default.
- W4289528305 cites W2041313059 @default.
- W4289528305 cites W2054983611 @default.
- W4289528305 cites W2089574951 @default.
- W4289528305 cites W2099567806 @default.
- W4289528305 cites W2126049444 @default.
- W4289528305 cites W2129168200 @default.
- W4289528305 cites W2135448701 @default.
- W4289528305 cites W2342925107 @default.
- W4289528305 cites W2570401594 @default.
- W4289528305 cites W2955092065 @default.
- W4289528305 cites W2984577809 @default.
- W4289528305 cites W2997677113 @default.
- W4289528305 cites W3055507597 @default.
- W4289528305 cites W3103132480 @default.
- W4289528305 cites W3214845715 @default.
- W4289528305 doi "https://doi.org/10.1053/j.semtcvs.2022.06.022" @default.
- W4289528305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35926763" @default.
- W4289528305 hasPublicationYear "2022" @default.
- W4289528305 type Work @default.
- W4289528305 citedByCount "1" @default.
- W4289528305 countsByYear W42895283052023 @default.
- W4289528305 crossrefType "journal-article" @default.
- W4289528305 hasAuthorship W4289528305A5023657268 @default.
- W4289528305 hasAuthorship W4289528305A5027848476 @default.
- W4289528305 hasAuthorship W4289528305A5029035012 @default.
- W4289528305 hasAuthorship W4289528305A5045712741 @default.
- W4289528305 hasAuthorship W4289528305A5049001836 @default.
- W4289528305 hasAuthorship W4289528305A5071516432 @default.
- W4289528305 hasConcept C121608353 @default.
- W4289528305 hasConcept C126322002 @default.
- W4289528305 hasConcept C141071460 @default.
- W4289528305 hasConcept C146357865 @default.
- W4289528305 hasConcept C151730666 @default.
- W4289528305 hasConcept C167135981 @default.
- W4289528305 hasConcept C17923572 @default.
- W4289528305 hasConcept C2777297899 @default.
- W4289528305 hasConcept C2779742542 @default.
- W4289528305 hasConcept C2780470880 @default.
- W4289528305 hasConcept C2781182431 @default.
- W4289528305 hasConcept C41008148 @default.
- W4289528305 hasConcept C50382708 @default.
- W4289528305 hasConcept C71924100 @default.
- W4289528305 hasConcept C72563966 @default.
- W4289528305 hasConcept C77088390 @default.
- W4289528305 hasConcept C86803240 @default.
- W4289528305 hasConcept C90924648 @default.
- W4289528305 hasConceptScore W4289528305C121608353 @default.
- W4289528305 hasConceptScore W4289528305C126322002 @default.
- W4289528305 hasConceptScore W4289528305C141071460 @default.
- W4289528305 hasConceptScore W4289528305C146357865 @default.
- W4289528305 hasConceptScore W4289528305C151730666 @default.
- W4289528305 hasConceptScore W4289528305C167135981 @default.
- W4289528305 hasConceptScore W4289528305C17923572 @default.
- W4289528305 hasConceptScore W4289528305C2777297899 @default.
- W4289528305 hasConceptScore W4289528305C2779742542 @default.
- W4289528305 hasConceptScore W4289528305C2780470880 @default.
- W4289528305 hasConceptScore W4289528305C2781182431 @default.
- W4289528305 hasConceptScore W4289528305C41008148 @default.
- W4289528305 hasConceptScore W4289528305C50382708 @default.
- W4289528305 hasConceptScore W4289528305C71924100 @default.
- W4289528305 hasConceptScore W4289528305C72563966 @default.
- W4289528305 hasConceptScore W4289528305C77088390 @default.
- W4289528305 hasConceptScore W4289528305C86803240 @default.
- W4289528305 hasConceptScore W4289528305C90924648 @default.
- W4289528305 hasLocation W42895283051 @default.
- W4289528305 hasLocation W42895283052 @default.
- W4289528305 hasOpenAccess W4289528305 @default.
- W4289528305 hasPrimaryLocation W42895283051 @default.
- W4289528305 hasRelatedWork W2084845148 @default.
- W4289528305 hasRelatedWork W2164787924 @default.
- W4289528305 hasRelatedWork W2412448412 @default.
- W4289528305 hasRelatedWork W2740584812 @default.
- W4289528305 hasRelatedWork W2945733336 @default.
- W4289528305 hasRelatedWork W2951860118 @default.
- W4289528305 hasRelatedWork W3153916282 @default.
- W4289528305 hasRelatedWork W3191941344 @default.
- W4289528305 hasRelatedWork W4285503836 @default.
- W4289528305 hasRelatedWork W4312100727 @default.
- W4289528305 isParatext "false" @default.
- W4289528305 isRetracted "false" @default.
- W4289528305 workType "article" @default.