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- W4289528992 abstract "The occlusion bodies (OBs) of certain alphabaculoviruses are polyhedrin-rich structures that mediate the collective transmission of tens of viral particles to the same insect host. In addition, in multiple nucleopolyhedroviruses, occlusion-derived virions (ODVs) form nucleocapsid aggregates that are delivered to the same host cell. It has been suggested that, by favoring coinfection, this transmission mode promotes evolutionarily stable interactions between different baculovirus variants. To quantify the joint transmission of different variants, we obtained OBs from cells coinfected with two viral constructs, each encoding a different fluorescent reporter, and used them for inoculating Spodoptera exigua larvae. The microscopy analysis of midguts revealed that the two reporter genes were typically segregated into different infection foci, suggesting that ODVs show limited ability to promote the co-transmission of different virus variants to the same host cell. However, a polyhedrin-deficient mutant underwent inter-host transmission by exploiting the OBs of a fully functional virus and re-acquired the lost gene through recombination, demonstrating cellular coinfection. Our results suggest that viral spatial segregation during transmission and primary infection limits interactions between different baculovirus variants, but that these interactions still occur within the cells of infected insects later in infection." @default.
- W4289528992 created "2022-08-03" @default.
- W4289528992 creator A5018927544 @default.
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- W4289528992 date "2022-07-31" @default.
- W4289528992 modified "2023-10-01" @default.
- W4289528992 title "Spatially Segregated Transmission of Co-Occluded Baculoviruses Limits Virus–Virus Interactions Mediated by Cellular Coinfection during Primary Infection" @default.
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- W4289528992 doi "https://doi.org/10.3390/v14081697" @default.
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