FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289594491> ?p ?o ?g. }

• W4289594491 endingPage "e2225345" @default.
• W4289594491 startingPage "e2225345" @default.
• W4289594491 abstract "<h3>Importance</h3> Though adjuvant endocrine therapy (AET) has proven efficacy in treating hormone receptor–positive (HR-positive) breast cancer, patient adherence to AET and continuation of treatment as recommended by guidelines remain suboptimal, especially for low-income patients. <h3>Objective</h3> To quantify timelines for initiating AET and assess their association with short- and long-term adherence and continuation of AET in low-income women with breast cancer. <h3>Design, Setting, and Participants</h3> This population-based retrospective cohort study included women younger than 65 years diagnosed with first primary HR-positive breast cancer between January 1, 2007, and December 31, 2013, followed up for 5 years after the first use of AET through December 2018, and identified from the linked Missouri Cancer Registry and Medicaid claims data set. <h3>Exposures</h3> Time to initiation (TTI) as days from the date of last treatment (surgery, radiotherapy, or chemotherapy) to the first date of AET prescription fill. <h3>Main Outcomes and Measures</h3> The main outcomes were adherence to AET as medication possession ratio of 80% or greater and continuation of AET as no gap in medication supply for at least 90 days. Odds ratios (ORs) of adherence and continuation over 1 to 5 years were estimated using logistic regression adjusted for demographic, clinical, and neighborhood variables. Analyses were performed between September 1, 2020, and May 31, 2022. <h3>Results</h3> Among 1711 patients, median TTI was 53 (IQR, 26-117) days. A total of 1029 patients (60.1%) were aged 50 to 64 years old, 1270 (74.2%) were non-Hispanic White, and 1133 (66.2%) were unmarried. In the first year after initiation, 1317 (77.0%) were adherent and 1015 (59.3%) continued AET. Over the full 5 years, 376 (22.0%) were adherent and 409 (23.9%) continued AET. Longer TTI was significantly associated with poorer adherence at every year, with an OR of 0.97 (95% CI, 0.95-0.99) for 1-year adherence and an OR of 0.94 (95% CI, 0.90-0.97) for 5-year adherence per 1-month increase in TTI. Longer TTI was also associated with lower odds of short-term, but not long-term, continuation (OR, 0.97 [95% CI, 0.95-0.99] for 1-year continuation and 0.98 [95% CI, 0.96-0.99] for 2-year continuation). <h3>Conclusions and Relevance</h3> In this cohort study, longer time to AET initiation was associated with lower odds of short-term and long-term adherence to AET in Medicaid-insured patients with breast cancer. Therefore, early interventions targeting treatment initiation timelines may positively impact adherence throughout the course of treatment and, therefore, outcomes." @default.
• W4289594491 created "2022-08-03" @default.
• W4289594491 creator A5000398292 @default.
• W4289594491 creator A5001577582 @default.
• W4289594491 creator A5004111279 @default.
• W4289594491 creator A5031201037 @default.
• W4289594491 creator A5049206561 @default.
• W4289594491 creator A5060002817 @default.
• W4289594491 creator A5089371437 @default.
• W4289594491 date "2022-08-03" @default.
• W4289594491 modified "2023-10-18" @default.
• W4289594491 title "Association of Endocrine Therapy Initiation Timeliness With Adherence and Continuation in Low-Income Women With Breast Cancer" @default.
• W4289594491 cites W1966511998 @default.
• W4289594491 cites W2023920949 @default.
• W4289594491 cites W2044702943 @default.
• W4289594491 cites W2063691918 @default.
• W4289594491 cites W2071003201 @default.
• W4289594491 cites W2075150199 @default.
• W4289594491 cites W2101944829 @default.
• W4289594491 cites W2102575484 @default.
• W4289594491 cites W2116810060 @default.
• W4289594491 cites W2118728607 @default.
• W4289594491 cites W2121656289 @default.
• W4289594491 cites W2139442403 @default.
• W4289594491 cites W2143295270 @default.
• W4289594491 cites W2145166201 @default.
• W4289594491 cites W2154877455 @default.
• W4289594491 cites W2157875208 @default.
• W4289594491 cites W2165535851 @default.
• W4289594491 cites W2419411016 @default.
• W4289594491 cites W2430273310 @default.
• W4289594491 cites W2518492958 @default.
• W4289594491 cites W2547428409 @default.
• W4289594491 cites W2553046504 @default.
• W4289594491 cites W2613379367 @default.
• W4289594491 cites W2615369972 @default.
• W4289594491 cites W2786957577 @default.
• W4289594491 cites W2796484277 @default.
• W4289594491 cites W2810092645 @default.
• W4289594491 cites W2856502828 @default.
• W4289594491 cites W2885061857 @default.
• W4289594491 cites W2891954278 @default.
• W4289594491 cites W2902182912 @default.
• W4289594491 cites W2904991649 @default.
• W4289594491 cites W2912993657 @default.
• W4289594491 cites W2943724507 @default.
• W4289594491 cites W2950294388 @default.
• W4289594491 cites W2966498361 @default.
• W4289594491 cites W2971201970 @default.
• W4289594491 cites W2979894921 @default.
• W4289594491 cites W3017376964 @default.
• W4289594491 cites W3086604159 @default.
• W4289594491 cites W3098907773 @default.
• W4289594491 cites W3148852287 @default.
• W4289594491 cites W3150387838 @default.
• W4289594491 cites W4206841660 @default.
• W4289594491 cites W4206953994 @default.
• W4289594491 cites W4226029083 @default.
• W4289594491 cites W4226237761 @default.
• W4289594491 cites W4235338201 @default.
• W4289594491 cites W4251210156 @default.
• W4289594491 cites W4251235761 @default.
• W4289594491 cites W4296024375 @default.
• W4289594491 cites W4376849581 @default.
• W4289594491 cites W2808809481 @default.
• W4289594491 doi "https://doi.org/10.1001/jamanetworkopen.2022.25345" @default.
• W4289594491 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35921108" @default.
• W4289594491 hasPublicationYear "2022" @default.
• W4289594491 type Work @default.
• W4289594491 citedByCount "3" @default.
• W4289594491 countsByYear W42895944912022 @default.
• W4289594491 countsByYear W42895944912023 @default.
• W4289594491 crossrefType "journal-article" @default.
• W4289594491 hasAuthorship W4289594491A5000398292 @default.
• W4289594491 hasAuthorship W4289594491A5001577582 @default.
• W4289594491 hasAuthorship W4289594491A5004111279 @default.
• W4289594491 hasAuthorship W4289594491A5031201037 @default.
• W4289594491 hasAuthorship W4289594491A5049206561 @default.
• W4289594491 hasAuthorship W4289594491A5060002817 @default.
• W4289594491 hasAuthorship W4289594491A5089371437 @default.
• W4289594491 hasBestOaLocation W42895944911 @default.
• W4289594491 hasConcept C121608353 @default.
• W4289594491 hasConcept C126322002 @default.
• W4289594491 hasConcept C151956035 @default.
• W4289594491 hasConcept C156957248 @default.
• W4289594491 hasConcept C167135981 @default.
• W4289594491 hasConcept C187212893 @default.
• W4289594491 hasConcept C201903717 @default.
• W4289594491 hasConcept C2426938 @default.
• W4289594491 hasConcept C2908647359 @default.
• W4289594491 hasConcept C530470458 @default.
• W4289594491 hasConcept C71924100 @default.
• W4289594491 hasConcept C72563966 @default.
• W4289594491 hasConcept C98274493 @default.
• W4289594491 hasConcept C99454951 @default.
• W4289594491 hasConceptScore W4289594491C121608353 @default.
• W4289594491 hasConceptScore W4289594491C126322002 @default.
• W4289594491 hasConceptScore W4289594491C151956035 @default.

• next