Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289596125> ?p ?o ?g. }
- W4289596125 endingPage "122072" @default.
- W4289596125 startingPage "122072" @default.
- W4289596125 abstract "Prior work has shown that microbubble-assisted delivery of oxygen improves tumor oxygenation and radiosensitivity, albeit over a limited duration. Lonidamine (LND) has been investigated because of its ability to stimulate glycolysis, lactate production, inhibit mitochondrial respiration, and inhibit oxygen consumption rates in tumors but suffers from poor bioavailability. The goal of this work was to characterize LND-loaded oxygen microbubbles and assess their ability to oxygenate a human head and neck squamous cell carcinoma (HNSCC) tumor model, while also assessing LND biodistribution. In tumors treated with surfactant-shelled microbubbles with oxygen core (SE61O2) and ultrasound, pO2 levels increased to a peak 19.5 ± 9.7 mmHg, 50 s after injection and returning to baseline after 120 s. In comparison, in tumors treated with SE61O2/LND and ultrasound, pO2 levels showed a peak increase of 29.0 ± 8.3 mmHg, which was achieved 70 s after injection returning to baseline after 300 s (p < 0.001). The co-delivery of O2 and LND via SE61 also showed an improvement of LND biodistribution in both plasma and tumor tissues (p < 0.001). In summary, ultrasound-sensitive microbubbles loaded with O2 and LND provided prolonged oxygenation relative to oxygenated microbubbles alone, as well as provided an ability to locally deliver LND, making them more appropriate for clinical translation." @default.
- W4289596125 created "2022-08-03" @default.
- W4289596125 creator A5003335525 @default.
- W4289596125 creator A5004066638 @default.
- W4289596125 creator A5008229350 @default.
- W4289596125 creator A5009808245 @default.
- W4289596125 creator A5010670331 @default.
- W4289596125 creator A5013933769 @default.
- W4289596125 creator A5015026678 @default.
- W4289596125 creator A5024354671 @default.
- W4289596125 creator A5038862540 @default.
- W4289596125 creator A5043915716 @default.
- W4289596125 creator A5046835429 @default.
- W4289596125 creator A5054875868 @default.
- W4289596125 creator A5059470788 @default.
- W4289596125 creator A5067330326 @default.
- W4289596125 creator A5072024057 @default.
- W4289596125 creator A5074090834 @default.
- W4289596125 date "2022-09-01" @default.
- W4289596125 modified "2023-10-14" @default.
- W4289596125 title "Tumoral oxygenation and biodistribution of Lonidamine oxygen microbubbles following localized ultrasound-triggered delivery" @default.
- W4289596125 cites W1582806874 @default.
- W4289596125 cites W1600582725 @default.
- W4289596125 cites W1842875237 @default.
- W4289596125 cites W1899435397 @default.
- W4289596125 cites W1976135553 @default.
- W4289596125 cites W1976374560 @default.
- W4289596125 cites W1996830477 @default.
- W4289596125 cites W1997339854 @default.
- W4289596125 cites W2006153373 @default.
- W4289596125 cites W2026377273 @default.
- W4289596125 cites W2026881684 @default.
- W4289596125 cites W2035625867 @default.
- W4289596125 cites W2046292319 @default.
- W4289596125 cites W2056624204 @default.
- W4289596125 cites W2070806047 @default.
- W4289596125 cites W2079153524 @default.
- W4289596125 cites W2091894720 @default.
- W4289596125 cites W2109294354 @default.
- W4289596125 cites W2110435930 @default.
- W4289596125 cites W2111120542 @default.
- W4289596125 cites W2149860264 @default.
- W4289596125 cites W2166207630 @default.
- W4289596125 cites W2167229055 @default.
- W4289596125 cites W2270187227 @default.
- W4289596125 cites W2288651793 @default.
- W4289596125 cites W2483796603 @default.
- W4289596125 cites W2612944657 @default.
- W4289596125 cites W2756960941 @default.
- W4289596125 cites W2791267538 @default.
- W4289596125 cites W2792817321 @default.
- W4289596125 cites W2796650882 @default.
- W4289596125 cites W2889646458 @default.
- W4289596125 cites W2906120852 @default.
- W4289596125 cites W2911188335 @default.
- W4289596125 cites W2919057047 @default.
- W4289596125 cites W2946762906 @default.
- W4289596125 cites W3007243931 @default.
- W4289596125 cites W3082675806 @default.
- W4289596125 cites W3105923034 @default.
- W4289596125 cites W3111503660 @default.
- W4289596125 cites W3134421739 @default.
- W4289596125 cites W3194180928 @default.
- W4289596125 cites W4210575080 @default.
- W4289596125 cites W4224046453 @default.
- W4289596125 doi "https://doi.org/10.1016/j.ijpharm.2022.122072" @default.
- W4289596125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35932933" @default.
- W4289596125 hasPublicationYear "2022" @default.
- W4289596125 type Work @default.
- W4289596125 citedByCount "3" @default.
- W4289596125 countsByYear W42895961252023 @default.
- W4289596125 crossrefType "journal-article" @default.
- W4289596125 hasAuthorship W4289596125A5003335525 @default.
- W4289596125 hasAuthorship W4289596125A5004066638 @default.
- W4289596125 hasAuthorship W4289596125A5008229350 @default.
- W4289596125 hasAuthorship W4289596125A5009808245 @default.
- W4289596125 hasAuthorship W4289596125A5010670331 @default.
- W4289596125 hasAuthorship W4289596125A5013933769 @default.
- W4289596125 hasAuthorship W4289596125A5015026678 @default.
- W4289596125 hasAuthorship W4289596125A5024354671 @default.
- W4289596125 hasAuthorship W4289596125A5038862540 @default.
- W4289596125 hasAuthorship W4289596125A5043915716 @default.
- W4289596125 hasAuthorship W4289596125A5046835429 @default.
- W4289596125 hasAuthorship W4289596125A5054875868 @default.
- W4289596125 hasAuthorship W4289596125A5059470788 @default.
- W4289596125 hasAuthorship W4289596125A5067330326 @default.
- W4289596125 hasAuthorship W4289596125A5072024057 @default.
- W4289596125 hasAuthorship W4289596125A5074090834 @default.
- W4289596125 hasBestOaLocation W42895961252 @default.
- W4289596125 hasConcept C126322002 @default.
- W4289596125 hasConcept C126838900 @default.
- W4289596125 hasConcept C143753070 @default.
- W4289596125 hasConcept C181389837 @default.
- W4289596125 hasConcept C185592680 @default.
- W4289596125 hasConcept C202751555 @default.
- W4289596125 hasConcept C2776530083 @default.
- W4289596125 hasConcept C2776833033 @default.
- W4289596125 hasConcept C2777807558 @default.